Aldehyde oxidase 1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.{{cite web | title = Entrez Gene: aldehyde oxidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=316}}{{cite journal |vauthors=Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D | title = Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis | journal = Somat. Cell Mol. Genet. | volume = 21 | issue = 2 | pages = 121–31 |date=March 1995 | pmid = 7570184 | doi = 10.1007/BF02255787| s2cid = 24691533 | url =https://zenodo.org/record/1232530 }}
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.
Clinical significance
Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.
See also
References
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External links
- {{UCSC gene info|AOX1}}
Further reading
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- {{cite journal |vauthors=Wang AG, Yoon SY, Oh JH |title=Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 3 |pages= 1022–32 |year= 2006 |pmid= 16712791 |doi= 10.1016/j.bbrc.2006.04.175 |display-authors=etal}}
- {{cite journal |vauthors=Smith MA, Marinaki AM, Arenas M |title=Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease. |journal=Aliment. Pharmacol. Ther. |volume=30 |issue= 4 |pages= 375–84 |year= 2009 |pmid= 19500084 |doi= 10.1111/j.1365-2036.2009.04057.x |s2cid=1292701 |display-authors=etal|doi-access= }}
- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. |journal=Mol. Med. |volume=16 |issue= 7–8 |pages= 247–53 |year= 2010|pmid= 20379614 |doi= 10.2119/molmed.2009.00159 |pmc=2896464|display-authors=etal}}
- {{cite journal |author1=Sigruener A |author2=Buechler C |author3=Orsó E |title=Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes. |journal=Horm. Metab. Res. |volume=39 |issue= 11 |pages= 781–9 |year= 2007 |pmid= 17992631 |doi= 10.1055/s-2007-992129 |s2cid=28460089 |display-authors=etal}}
- {{cite journal |vauthors=Ichida K, Matsumura T, Sakuma R |title=Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 5 |pages= 1194–200 |year= 2001 |pmid= 11302742 |doi= 10.1006/bbrc.2001.4719 |display-authors=etal}}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi= 10.1101/gr.6.9.791|doi-access=free }}
- {{cite journal |vauthors=Alfaro JF, Joswig-Jones CA, Ouyang W |title=Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli. |journal=Drug Metab. Dispos. |volume=37 |issue= 12 |pages= 2393–8 |year= 2009 |pmid= 19741035 |doi= 10.1124/dmd.109.029520 |pmc=2784701|display-authors=etal}}
- {{cite journal |author =Rodrigues AD |title=Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro. |journal=Biochem. Pharmacol. |volume=48 |issue= 1 |pages= 197–200 |year= 1994 |pmid= 8043023 |doi= 10.1016/0006-2952(94)90240-2 }}
- {{cite journal |vauthors=Wright RM, Vaitaitis GM, Wilson CM |title=cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10690–4 |year= 1993 |pmid= 8248161 |doi= 10.1073/pnas.90.22.10690 |pmc=47843|bibcode=1993PNAS...9010690W |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Buechler C, Boettcher A, Bared SM |title=The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 2 |pages= 759–65 |year= 2002 |pmid= 12054535 |doi= 10.1016/S0006-291X(02)00303-0 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors =Ross CJ, Katzov-Eckert H, Dubé MP |title=Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. |journal=Nat. Genet. |volume=41 |issue= 12 |pages= 1345–9 |year= 2009 |pmid= 19898482 |doi= 10.1038/ng.478 |s2cid=21293339 |display-authors=etal}}
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{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}
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