Alezzandrini syndrome
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| field = Dermatology
| symptoms = Loss of vision, facial vitiligo, sound sensitivity
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| causes = Unknown
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Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis.{{cite book | vauthors = James W, Berger T, Elston D | date = 2005 | title = Andrews' Diseases of the Skin: Clinical Dermatology | edition = 10th | publisher = Saunders | isbn = 0-7216-2921-0}}{{rp|864}}{{cite journal | vauthors = Gupta M, Pande D, Lehl SS, Sachdev A | title = Alezzandrini syndrome | journal = BMJ Case Reports | volume = 2011 | issue = aug17 1 | pages = bcr0420114052 | date = August 2011 | pmid = 22688932 | pmc = 3171053 | doi = 10.1136/bcr.04.2011.4052 }} Deafness may also be present.{{rp|864}}{{cite book | vauthors = Rapini RP, Bolognia JL, Jorizzo JL |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages=918 |isbn=978-1-4160-2999-1 }}
Signs and symptoms
Initially, there is a progressive loss of visual acuity, mostly in one eye. Infected areas experience pigmentation loss in the skin and hair. Unilateral tapetoretinal degeneration accompanied by the ipsilateral appearance of facial vitiligo and poliosis is the hallmark of Alezzandrini syndrome.{{cite journal | last=Janniger | first=Camila K | title=Alezzandrini Syndrome: Practice Essentials, Pathophysiology, Epidemiology | website=Medscape Reference | date=June 8, 2022 |url=https://emedicine.medscape.com/article/1117255-overview | access-date=January 24, 2024}}
Causes
Diagnosis
Treatment
Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive depigmentation. Topical steroids may be used to treat vitiligo in specific areas. People who have vitiligo should wear sunscreen to avoid getting sunburned and developing skin cancer later on.
See also
References
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External links
- [https://dermnetnz.org/topics/alezzandrini-syndrome DermNet]
{{Medical resources
| ICD11 = {{ICD11|ED63.Y}}
| ICD10 = {{ICD10|L81.8}}
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| DiseasesDB = 34138
| SNOMED CT = 403275004
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| eMedicineSubj = article
| eMedicineTopic = 1117255
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| GARDNum = 13023
| GARDName = Alezzandrini syndrome
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| Scholia = Q4721578
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Category:Disturbances of human pigmentation
Category:Syndromes affecting the retina