Allan Bradley
{{Short description|British geneticist}}
{{Other people|Alan Bradley}}
{{EngvarB|date=August 2017}}
{{Use dmy dates|date=August 2017}}
{{Infobox scientist
| name = Allan Bradley
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| image = Professor Sir Allan Bradley, Founder & Chief Scientific Officer at the launch of the Shakespeare Review (8740129867).jpg
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| caption = Allan Bradley at the launch of the Shakespeare review, organised by Policy Exchange
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| birth_name = Allan Bradley
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| fields = Mouse genomics{{Cite journal
| last1 = Donehower | first1 = L. A.
| last2 = Harvey | first2 = M.
| last3 = Slagle | first3 = B. L.
| last4 = McArthur | first4 = M. J.
| last5 = Montgomery Jr | first5 = C. A.
| last6 = Butel | first6 = J. S.
| last7 = Bradley | first7 = A.
| doi = 10.1038/356215a0
| title = Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
| journal = Nature
| volume = 356
| issue = 6366
| pages = 215–221
| year = 1992
| pmid = 1552940
| bibcode = 1992Natur.356..215D
| s2cid = 4348340
}}{{Cite journal | last1 = Dalton | first1 = D. | last2 = Pitts-Meek | first2 = S. | last3 = Keshav | first3 = S. | last4 = Figari | first4 = I. | last5 = Bradley | first5 = A. | last6 = Stewart | first6 = T. | doi = 10.1126/science.8456300 | title = Multiple defects of immune cell function in mice with disrupted interferon-gamma genes | journal = Science | volume = 259 | issue = 5102 | pages = 1739–1742 | year = 1993 | pmid = 8456300| bibcode = 1993Sci...259.1739D }}{{Cite journal | last1 = Guo | first1 = G. | last2 = Wang | first2 = W. | last3 = Bradley | first3 = A. | doi = 10.1038/nature02653 | title = Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells | journal = Nature | volume = 429 | issue = 6994 | pages = 891–895 | year = 2004 | pmid = 15215866| bibcode = 2004Natur.429..891G | s2cid = 2545884 }}{{Cite journal | last1 = Kile | first1 = B. T. | last2 = Hentges | first2 = K. E. | last3 = Clark | first3 = A. T. | last4 = Nakamura | first4 = H. | last5 = Salinger | first5 = A. P. | last6 = Liu | first6 = B. | last7 = Box | first7 = N. | last8 = Stockton | first8 = D. W. | last9 = Johnson | first9 = R. L. | last10 = Behringer | first10 = R. R. | last11 = Bradley | first11 = A. | last12 = Justice | first12 = M. J. | doi = 10.1038/nature01865 | title = Functional genetic analysis of mouse chromosome 11 | journal = Nature | volume = 425 | issue = 6953 | pages = 81–86 | year = 2003 | pmid = 12955145| bibcode = 2003Natur.425...81K | s2cid = 4409237 }}{{cite web|archive-url=https://web.archive.org/web/20100401121618/http://www.sanger.ac.uk/research/projects/mousegenomics|archive-date=2010-04-01|url=http://www.sanger.ac.uk/research/projects/mousegenomics|publisher=Wellcome Trust Sanger Institute|title=Mouse genomics – Allan Bradley laboratory}}
| workplaces = {{Plainlist|
| alma_mater = University of Cambridge (BA, MA, PhD){{Who's Who | title=BRADLEY, Prof. Allan | id = U43742 | volume = 2014 | edition = online Oxford University Press}}
| thesis_title = Isolation characterisation and developmental potential of murine embryo-derived stem cells
| thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373263
| thesis_year =1986
| doctoral_advisor = Martin Evans{{cite journal|last1=Watts|first1=Geoff|title=Martin Evans: joint winner of 2007 Nobel Prize in medicine|journal=The Lancet|volume=370|issue=9605|year=2007|pages=2095|issn=0140-6736|doi=10.1016/S0140-6736(07)61889-3|pmid= 18156018|s2cid=7800773}}
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| known_for = Embryonic stem cells
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| awards = {{Plainlist|
- Searle Scholar (1988)
- EMBO member (2006){{cite web|url=http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pd|title=The EMBO Pocket Directory|archive-url=https://web.archive.org/web/20150316002020/http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pdf|archive-date=2015-03-16|publisher=European Molecular Biology Organization}}
- FRS (2002)}}
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| website = {{URL|sanger.ac.uk/person/bradley-allan/}}
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Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute.{{cite web |url=http://www.wellcome.ac.uk/News/2010/Features/WTX059873.htm |title=Professor Allan Bradley: a decade at Sanger | Wellcome Trust |publisher=Wellcome.ac.uk |date=15 June 2010 |access-date=2012-04-04 |archive-url=https://web.archive.org/web/20101203010331/http://www.wellcome.ac.uk/News/2010/Features/WTX059873.htm |archive-date=3 December 2010 |url-status=dead }}{{cite web|url=http://www.sanger.ac.uk/about/press/2002/020513.html |title=Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society – Wellcome Trust Sanger Institute |publisher=Sanger.ac.uk |access-date=2012-04-04}}{{Scopus|55605072700}}{{cite news| url=http://news.nationalpost.com/2011/10/12/new-stem-cell-method-could-end-need-for-liver-transplants-scientists/#more-99581| title=New stem cell method could end need for liver transplants|author=Kate Kelland| work=National Post| date=12 October 2011}}
Education
Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD{{cite thesis|degree=PhD|publisher=University of Cambridge|title=Isolation characterization and developmental potential of murine embryo-derived stem cells.|first= A.|last=Bradley|year=1985|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373263}} degrees in genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans.{{cite web|url=http://www.sanger.ac.uk/about/people/biographies/abradley.html |title=Allan Bradley – Wellcome Trust Sanger Institute |publisher=Sanger.ac.uk |archive-url=https://web.archive.org/web/20131113144014/http://www.sanger.ac.uk/research/faculty/abradley/|archive-date=2013-11-13}}
Career
Following his PhD, Bradley was appointed assistant professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988.{{cite web|url=http://www.searlescholars.net/person/318 |title=Searle Scholars Program: Allan Bradley (1988) |publisher=Searlescholars.net |access-date=2012-04-04}} Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston) to April 2010, succeeded by Michael Stratton.
Awards and honours
Bradley won a 1994 DeBakey Award{{cite web|url=http://www.bcm.edu/debakeyawards/Bradley.html |archive-url=https://archive.today/20120719182953/http://www.bcm.edu/debakeyawards/Bradley.html |url-status=dead |archive-date=2012-07-19 |title=Bradley – DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas |publisher=Bcm.edu |access-date=2012-04-04}} and was elected a Fellow of the Royal Society (FRS) in 2002. His certificate of election reads: {{blockquote|text="Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era."{{cite web|url=https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F2002%2F01%27) |title=Certificate of election EC/2002/01: Allan Bradley |publisher=The Royal Society |access-date=2013-11-14 |location=London |archive-url=https://web.archive.org/web/20150903180706/https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F2002%2F01%27) |archive-date=2015-09-03 |url-status=dead }}}}
References
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{{S-start}}
{{s-npo}}
{{s-bef | before = John Sulston}}
{{s-ttl | title = Director of the Wellcome Trust Sanger Institute | years = 2000–2010}}
{{s-aft | after = Michael Stratton}}
{{S-end}}
{{Wellcome Trust}}
{{FRS 2002}}
{{Authority control}}
{{DEFAULTSORT:Bradley, Allan}}
Category:Alumni of Trinity College, Cambridge
Category:Members of the European Molecular Biology Organization
Category:Baylor College of Medicine faculty
Category:Fellows of the Royal Society