Alpha-1D adrenergic receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.{{cite web | title = Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146}}

Many α₁ receptor ligands are non-selective for receptor subtypes.

; Antagonists

• A-315456{{cite journal | vauthors = Buckner SA, Milicic I, Daza A, Lynch JJ, Kolasa T, Nakane M, Sullivan JP, Brioni JD | title = A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity | journal = European Journal of Pharmacology | volume = 433 | issue = 1 | pages = 123–127 | date = December 2001 | pmid = 11755142 | doi = 10.1016/s0014-2999(01)01519-9 }}
• BMY 7378 (also α_2C antagonist){{cite journal | vauthors = Cleary L, Murad K, Bexis S, Docherty JR | title = The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist | journal = Autonomic & Autacoid Pharmacology | volume = 25 | issue = 4 | pages = 135–141 | date = October 2005 | pmid = 16176444 | doi = 10.1111/j.1474-8673.2005.00342.x }}
• Domesticine{{cite journal | vauthors = Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Muramatsu I, Taniguchi T, Ohizumi Y | title = (+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors | journal = European Journal of Pharmacology | volume = 445 | issue = 1-2 | pages = 21–29 | date = June 2002 | pmid = 12065190 | doi = 10.1016/s0014-2999(02)01601-1 }}
• Cyclazosin (slight α_1C selectivity){{cite journal | vauthors = Proudman RG, Pupo AS, Baker JG | title = The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors | journal = Pharmacology Research & Perspectives | volume = 8 | issue = 4 | pages = e00602 | date = August 2020 | pmid = 32608144 | pmc = 7327383 | doi = 10.1002/prp2.602 }}
• Tamsulosin (roughly equal affinity for α_1A)

• Adrenergic receptor

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Schwinn DA, Lomasney JW | title = Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype | journal = European Journal of Pharmacology | volume = 227 | issue = 4 | pages = 433–436 | date = December 1992 | pmid = 1359975 | doi = 10.1016/0922-4106(92)90162-O }}
• {{cite journal | vauthors = Bruno JF, Whittaker J, Song JF, Berelowitz M | title = Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor | journal = Biochemical and Biophysical Research Communications | volume = 179 | issue = 3 | pages = 1485–1490 | date = September 1991 | pmid = 1656955 | doi = 10.1016/0006-291X(91)91740-4 }}
• {{cite journal | vauthors = Esbenshade TA, Hirasawa A, Tsujimoto G, Tanaka T, Yano J, Minneman KP, Murphy TJ | title = Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells | journal = Molecular Pharmacology | volume = 47 | issue = 5 | pages = 977–985 | date = May 1995 | pmid = 7746284 }}
• {{cite journal | vauthors = Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ | title = Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 272 | issue = 1 | pages = 134–142 | date = January 1995 | pmid = 7815325 }}
• {{cite journal | vauthors = Weinberg DH, Trivedi P, Tan CP, Mitra S, Perkins-Barrow A, Borkowski D, Strader CD, Bayne M | title = Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c | journal = Biochemical and Biophysical Research Communications | volume = 201 | issue = 3 | pages = 1296–1304 | date = June 1994 | pmid = 8024574 | doi = 10.1006/bbrc.1994.1845 }}
• {{cite journal | vauthors = Loftus SK, Shiang R, Warrington JA, Bengtsson U, McPherson JD, Wasmuth JJ | title = Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5 | journal = Cytogenetics and Cell Genetics | volume = 67 | issue = 2 | pages = 69–74 | year = 1994 | pmid = 8039425 | doi = 10.1159/000133802 }}
• {{cite journal | vauthors = Yang-Feng TL, Han H, Lomasney JW, Caron MG | title = Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13 | journal = Cytogenetics and Cell Genetics | volume = 66 | issue = 3 | pages = 170–171 | year = 1994 | pmid = 8125015 | doi = 10.1159/000133693 }}
• {{cite journal | vauthors = Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA | title = The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype | journal = Molecular Pharmacology | volume = 45 | issue = 4 | pages = 703–708 | date = April 1994 | pmid = 8183249 }}
• {{cite journal | vauthors = Minneman KP, Lee D, Zhong H, Berts A, Abbott KL, Murphy TJ | title = Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes | journal = Journal of Neurochemistry | volume = 74 | issue = 6 | pages = 2392–2400 | date = June 2000 | pmid = 10820200 | doi = 10.1046/j.1471-4159.2000.0742392.x | s2cid = 16002509 | doi-access = free }}
• {{cite journal | vauthors = Keffel S, Alexandrov A, Goepel M, Michel MC | title = alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells | journal = Biochemical and Biophysical Research Communications | volume = 272 | issue = 3 | pages = 906–911 | date = June 2000 | pmid = 10860850 | doi = 10.1006/bbrc.2000.2850 }}
• {{cite journal | vauthors = Kyprianou N, Benning CM | title = Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis | journal = Cancer Research | volume = 60 | issue = 16 | pages = 4550–4555 | date = August 2000 | pmid = 10969806 }}
• {{cite journal | vauthors = Shibata K, Katsuma S, Koshimizu T, Shinoura H, Hirasawa A, Tanoue A, Tsujimoto G | title = alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 1 | pages = 672–678 | date = January 2003 | pmid = 12409310 | doi = 10.1074/jbc.M201375200 | doi-access = free }}
• {{cite journal | vauthors = Pupo AS, Minneman KP | title = Specific interactions between gC1qR and alpha1-adrenoceptor subtypes | journal = Journal of Receptor and Signal Transduction Research | volume = 23 | issue = 2-3 | pages = 185–195 | year = 2004 | pmid = 14626446 | doi = 10.1081/RRS-120025200 | s2cid = 29600903 }}
• {{cite journal | vauthors = Hague C, Uberti MA, Chen Z, Hall RA, Minneman KP | title = Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors | journal = The Journal of Biological Chemistry | volume = 279 | issue = 15 | pages = 15541–15549 | date = April 2004 | pmid = 14736874 | doi = 10.1074/jbc.M314014200 | doi-access = free }}
• {{cite journal | vauthors = Gonzalez-Cabrera PJ, Shi T, Yun J, McCune DF, Rorabaugh BR, Perez DM | title = Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes | journal = Endocrinology | volume = 145 | issue = 11 | pages = 5157–5167 | date = November 2004 | pmid = 15297446 | doi = 10.1210/en.2004-0728 | doi-access = free }}
• {{cite journal | vauthors = Zhang T, Xu Q, Chen FR, Han QD, Zhang YY | title = Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors | journal = Acta Pharmacologica Sinica | volume = 25 | issue = 11 | pages = 1471–1478 | date = November 2004 | pmid = 15525470 }}
• {{cite journal | vauthors = Sigala S, Dellabella M, Milanese G, Fornari S, Faccoli S, Palazzolo F, Peroni A, Mirabella G, Cunico SC, Spano P, Muzzonigro G | title = Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter | journal = Neurourology and Urodynamics | volume = 24 | issue = 2 | pages = 142–148 | year = 2005 | pmid = 15690361 | doi = 10.1002/nau.20097 | s2cid = 23187341 }}
• {{cite journal | vauthors = Chen Z, Hague C, Hall RA, Minneman KP | title = Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction | journal = The Journal of Biological Chemistry | volume = 281 | issue = 18 | pages = 12414–12420 | date = May 2006 | pmid = 16533813 | doi = 10.1074/jbc.M508651200 | doi-access = free }}
• {{cite journal | vauthors = Michelotti GA, Brinkley DM, Morris DP, Smith MP, Louie RJ, Schwinn DA | title = Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation | journal = FASEB Journal | volume = 21 | issue = 9 | pages = 1979–1993 | date = July 2007 | pmid = 17384146 | pmc = 2279228 | doi = 10.1096/fj.06-7118com | doi-access = free }}

{{refend}}

• {{UCSC gene info|ADRA1A}}
• {{UCSC gene info|ADRA1D}}

{{G protein-coupled receptors}}

Category:Adrenergic receptors

{{transmembranereceptor-stub}}