Andrew Lumsden (scientist)

Andrew Lumsden attended Kingswood School in Bath, Somerset (as Andrew Sita-Lumsden) and graduated from St. Catharine's College, Cambridge with Double First Class Honours in Natural Sciences. After visiting Yale University for two years as a Fulbright Scholar, he returned to England to complete his PhD in Developmental Biology at the University of London.

Lumsden has held various lectureships at Guy's Hospital Medical School and the United Medical Schools of Guy's and St. Thomas' Hospital before being made a full Professor of the University of London in 1989. He has been an International Scholar of the Howard Hughes Medical Institute (1993–1998) and a Miller Institute visiting professor at the University of California, Berkeley (1994).

Lumsden has served on the Medical Research Council Neurosciences and Mental Health Board and Grants Committee (1992—1998), the Wellcome Trust Neuroscience Funding Committee (1997—2000), and the Brain Functions Grant Review Committee of the Human Frontier Science Program (1998—2001). He has also served as editor of Development{{cite web|url=http://www.biologists.com/Development|title=Development - The Company of Biologists}} (1995—2007) and is co-founder of the on-line, open-access journal Neural Development.{{cite web|url=http://www.neuraldevelopment.com|title=Neural Development|website=Neural Development}} In addition, Andrew Lumsden is a co-Head of Section for Faculty of 1000.{{cite web|url=http://f1000biology.com/about/biography/1000251023259107 |title=Andrew Lumsden: Advisory Board Member in Neurodevelopment: F1000Prime |website=f1000biology.com |url-status=dead |archive-url=https://web.archive.org/web/20100201160613/http://f1000biology.com/about/biography/1000251023259107 |archive-date=1 February 2010 }}

Andrew Lumsden has co-authored a book entitled The Developing Brain with Michael Brown and Roger Keynes.{{cite book|last=Brown|first=Michael|author2=Roger Keynes |author3=Andrew Lumsden |title=The Developing Brain|publisher=Oxford University Press|date=February 14, 2002|isbn=978-0-19-854793-8}} Following his PhD on epithelial-mesenchymal interactions in mammalian development, Lumsden's interest moved to the question of how integumental structures, such as teeth and vibrissae acquire their nerve supply, and how the cranial neural crest contributes to their patterning. Studies on the development of the trigeminal nerve and ganglion led on to observations of the organisation of their corresponding motor and sensory regions of the central nervous system. His seminal observations and experiments on the developing hindbrain of mammal and bird embryos confirmed the long suggested but never agreed view that this brain region has a rigidly segmented organisation, much like the body plan of insects and worms. To assist his research, he developed the Lumsden BioScissors™.{{cite web|url=http://www.bio-rad.com/LifeScience/pdf/bioscissors.pdf |title=Lumsden Bioscissors™ |website=bio-rad.com |url-status=dead |archive-url=https://web.archive.org/web/20110726222534/http://www.bio-rad.com/LifeScience/pdf/bioscissors.pdf |archive-date=26 July 2011 }}{{cite web|url=http://obanpi.co.uk |title=Obanpi |website=obanpi.co.uk |url-status=dead |archive-url=https://web.archive.org/web/20110709030309/http://obanpi.co.uk/ |archive-date=9 July 2011 }} Most recently, he has focussed on the developing forebrain, where he discovered signalling properties in a small set of cells that pattern the large surrounding region of the thalamus.

Lumsden was elected a Fellow of the Royal Society (elected 1994), a Fellow of the Academy of Medical Sciences (1998), and a Fellow of King's College London (1999). He was also elected an EMBO Member in 2008.{{citation needed|date=July 2017}}

In 2001, he was awarded The Ferrier Lecture and medal by the Royal Society{{cite web|url=http://www.royalsoc.ac.uk/royalsoc/mee_ferr.htm |title=Royal Society prize |url-status=dead |archive-url=https://web.archive.org/web/20030414005949/http://www.royalsoc.ac.uk/royalsoc/mee_ferr.htm |archive-date=14 April 2003 }} and in 2007, the W. Maxwell Cowan Prize{{cite web|url=http://www.cajalclub.org/id17.html |title=Cowan and Palay Awards |website=cajalclub.org |url-status=dead |archive-url=https://web.archive.org/web/20110725123132/http://www.cajalclub.org/id17.html |archive-date=25 July 2011 }} for "outstanding contributions in developmental neuroscience".

Lumsden has also been elected Freeman of the Worshipful Company of Clockmakers in 2006, and raised to the Livery in 2016.

Lumsden's publications{{Scopus id}} include:

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• {{cite journal |vauthors=Lumsden AG, Davies AM |title=Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor |journal=Nature |volume=306 |issue=5945 |pages=786–8 |year=1983 |pmid=6656880 |doi=10.1038/306786a0 |bibcode=1983Natur.306..786L |s2cid=4317445 }}
• {{cite journal |vauthors=Lumsden AG, Davies AM |title=Chemotropic effect of specific target epithelium in the developing mammalian nervous system |journal=Nature |volume=323 |issue=6088 |pages=538–9 |year=1986 |pmid=3762707 |doi=10.1038/323538a0 |bibcode=1986Natur.323..538L |s2cid=4363988 }}
• {{cite journal |vauthors=Tessier-Lavigne M, Placzek M, Lumsden AG, Dodd J, Jessell TM |title=Chemotropic guidance of developing axons in the mammalian central nervous system |journal=Nature |volume=336 |issue=6201 |pages=775–8 |year=1988 |pmid=3205306 |doi=10.1038/336775a0 |bibcode=1988Natur.336..775T |s2cid=4247407 }}
• {{cite journal |author=Lumsden A |title=Multipotent cells in the avian neural crest |journal=Trends Neurosci. |volume=12 |issue=3 |pages=81–3 |date=March 1989 |pmid=2469219 |doi= 10.1016/0166-2236(89)90159-8|s2cid=31991456 }}
• {{cite journal |vauthors=Lumsden A, Keynes R |title=Segmental patterns of neuronal development in the chick hindbrain |journal=Nature |volume=337 |issue=6206 |pages=424–8 |date=February 1989 |pmid=2644541 |doi=10.1038/337424a0 |bibcode=1989Natur.337..424L |s2cid=4262186 }}
• {{cite journal |vauthors=Heffner CD, Lumsden AG, O'Leary DD |title=Target control of collateral extension and directional axon growth in the mammalian brain |journal=Science |volume=247 |issue=4939 |pages=217–20 |date=January 1990 |pmid=2294603 |doi= 10.1126/science.2294603 |bibcode=1990Sci...247..217H }}
• {{cite journal |vauthors=Fraser S, Keynes R, Lumsden A |title=Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions |journal=Nature |volume=344 |issue=6265 |pages=431–5 |date=March 1990 |pmid=2320110 |doi=10.1038/344431a0 |bibcode=1990Natur.344..431F |s2cid=4355552 }}
• {{cite journal |author=Lumsden A |title=The cellular basis of segmentation in the developing hindbrain |journal=Trends Neurosci. |volume=13 |issue=8 |pages=329–35 |date=August 1990 |pmid=1699318 |doi= 10.1016/0166-2236(90)90144-Y|s2cid=3997227 }}
• {{cite journal |vauthors=Lumsden A, Sprawson N, Graham A |title=Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo |journal=Development |volume=113 |issue=4 |pages=1281–91 |date=December 1991 |doi=10.1242/dev.113.4.1281 |pmid=1811942 }}
• {{cite journal |vauthors=Guthrie S, Muchamore I, Kuroiwa A, Marshall H, Krumlauf R, Lumsden A |title=Neuroectodermal autonomy of Hox-2.9 expression revealed by rhombomere transpositions |journal=Nature |volume=356 |issue=6365 |pages=157–9 |date=March 1992 |pmid=1545869 |doi=10.1038/356157a0 |bibcode=1992Natur.356..157G |s2cid=4346647 }}
• {{cite journal |vauthors=Simon H, Lumsden A |title=Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midline |journal=Neuron |volume=11 |issue=2 |pages=209–20 |date=August 1993 |pmid=8394719 |doi= 10.1016/0896-6273(93)90179-U|s2cid=35121927 }}
• {{cite journal |vauthors=Lumsden A, Clarke JD, Keynes R, Fraser S |title=Early phenotypic choices by neuronal precursors, revealed by clonal analysis of the chick embryo hindbrain |journal=Development |volume=120 |issue=6 |pages=1581–9 |date=June 1994 |doi=10.1242/dev.120.6.1581 |pmid=8050364 }}
• {{cite journal |vauthors=Graham A, Francis-West P, Brickell P, Lumsden A |title=The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest |journal=Nature |volume=372 |issue=6507 |pages=684–6 |date=December 1994 |pmid=7990961 |doi=10.1038/372684a0 |bibcode=1994Natur.372..684G |s2cid=4361935 }}
• {{cite journal |vauthors=Logan C, Wizenmann A, Drescher U, Monschau B, Bonhoeffer F, Lumsden A |title=Rostral optic tectum adopts a caudal phenotype following ectopic Engrailed expression |journal=Current Biology |volume=6 |pages=1006–1014 |year=1996 |pmid=8805331 |issue=8 |doi=10.1016/S0960-9822(02)00645-0|s2cid=15159391 |doi-access=free }}
• {{cite journal |vauthors=Lumsden A, Krumlauf R |title=Patterning the vertebrate neuraxis |journal=Science |volume=274 |pages=1109–1115 |year=1996 |pmid=8895453 |issue=5290 |doi=10.1126/science.274.5290.1109|bibcode=1996Sci...274.1109L |s2cid=10891464 }}
• {{cite journal |vauthors=Studer M, Lumsden A, Ariza-McNaughton L, Bradley A, Krumlauf R |title=Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1 |journal=Nature |volume=384 |pages=630–634 |year=1996 |pmid=8967950 |doi=10.1038/384630a0 |issue=6610|bibcode=1996Natur.384..630S |s2cid=4317559 }}
• {{cite journal |author=Bell E, Wingate, R. Lumsden A.|title=Homeotic transformation of rhombomere identity following localised Hoxb1 misexpression |journal=Science |volume=284 |pages=2168–2171 |year=1999 |pmid=10381880 |issue=5423 |doi=10.1126/science.284.5423.2168}}
• {{cite journal |vauthors=Fortin G, Jungbluth S, Lumsden A, Champagnat J |title=Segmental specification of GABAergic inhibition during development of hindbrain neural networks |journal=Nature Neuroscience |volume=2 |pages=873–877 |year=1999 |pmid=10491606 |url= http://hal.archives-ouvertes.fr/docs/00/08/39/06/PDF/GABTX999.pdf|doi=10.1038/13172 |issue=10|s2cid=27168904 }}
• {{cite journal |vauthors=Zeltser L, Larsen C, Lumsden A |title=A new developmental compartment in the forebrain regulated by Lunatic fringe |journal=Nature Neuroscience |volume=4 |pages=683–684 |year=2001 |pmid=11426219 |doi=10.1038/89455 |issue=7|s2cid=26205097 }}
• {{cite journal |vauthors=Larsen C, Zeltser L, Lumsden A |title=Boundary formation and compartition in the avian diencephalon |journal=Journal of Neuroscience |volume=21 |pages=4699–4711 |year=2001 |pmid=11425897 |doi=10.1523/jneurosci.21-13-04699.2001 |issue=13|pmc=6762343 |doi-access=free }}
• {{cite journal |vauthors=Matsumoto K, Nishihara S, Kamimura M, Shiraishi T, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T |title=The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation |journal=Nature Neuroscience |volume=7 |pages=605–612 |year=2004 |pmid=15133517 |doi=10.1038/nn1249 |issue=6|s2cid=23807922 }}
• {{cite journal |vauthors=Kiecker C, Lumsden A |title=Hedgehog signalling from the zona limitans intrathalamica regulates the emergence of thalamic and prethalamic identity |journal=Nature Neuroscience |volume=7 |pages=1242–1249 |year=2004 |pmid=15494730 |doi=10.1038/nn1338 |issue=11|s2cid=29863625 }}
• {{cite journal |vauthors=Kiecker C, Lumsden A |title=Compartments and their boundaries in vertebrate brain development |journal=Nature Reviews Neuroscience |volume=6 |pages=553–564 |year=2005 |pmid=15959467 |doi=10.1038/nrn1702 |issue=7|s2cid=10869618 }}
• {{cite journal |vauthors=Scholpp S, Delogu A, Gilthorpe J, Peukert D, Lumsden A |title=Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=106 |pages=19895–19900 |year=2009 |pmid=19903880 |doi=10.1073/pnas.0910894106 |issue=47 |pmc=2775703|bibcode=2009PNAS..10619895S |doi-access=free }}
• {{cite journal |vauthors=Scholpp S, Lumsden A |title=Building a bridal chamber: development of the thalamus |journal=Trends in Neurosciences |volume=33 |pages=373–380 |year=2010 |pmid=20541814 |doi=10.1016/j.tins.2010.05.003 |issue=8 |pmc=2954313}}
• {{cite journal |vauthors=Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A |title=Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms |journal=Neuron |volume=75 |pages=648–662 |year=2012 |pmid=22920256 |doi=10.1016/j.neuron.2012.06.013 |issue=4|doi-access=free }}
• {{cite journal |vauthors=Gilthorpe JD, Oozeer F, Nash J, Calvo M, Bennett DL, Lumsden A, Pini A |title=Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia|journal=F1000Research |volume= 2|year=2013 |pmid=24358859 |doi= 10.12688/f1000research.2-148.v1|pmc=3782347 |pages=148 |doi-access=free }}

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Category:Fellows of the Royal Society

Category:1947 births

Category:Living people

Category:Alumni of St Catharine's College, Cambridge

Category:British neuroscientists

Category:Fellows of King's College London

Category:Academics of the University of London

Category:Members of the European Molecular Biology Organization

Category:Academics of King's College London

Category:Fellows of the Academy of Medical Sciences (United Kingdom)

Category:People educated at Kingswood School, Bath