Andrew Oates
{{short description|Australian-British embryologist}}
{{Use dmy dates|date=April 2022}}
{{Infobox academic
| honorific_prefix = Professor
| name = Andrew Oates
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| image = EPFL Andrew Oates 2021.jpg
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| caption = Andy Oates in 2020
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| birth_date = {{birth year and age|1969}}
| birth_place = Adelaide, Australia
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| citizenship = Australian
British
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| occupation = Full Professor
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| known_for = Segmentation of the zebrafish body axis by the genetic oscillations
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| website = https://www.epfl.ch/labs/oateslab/
| education = Biology
| alma_mater = University of Adelaide
University of Melbourne
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| doctoral_advisor = Andrew F Wilks
| academic_advisors = Robert Ho
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| discipline = Biology
| sub_discipline = Embryology
| workplaces = EPFL (École Polytechnique Fédérale de Lausanne)
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| main_interests = Developmental biology
Genetic oscillations
Biophysics
Embryology
Synchronization
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Andrew 'Andy' Charles Oates (born 1969 in Adelaide, Australia) is an Australian and British developmental biologist and embryologist specialized in biological pattern formation. He is professor at EPFL (École Polytechnique Fédérale de Lausanne) and head of the Segmentation Timing and Dynamics Laboratory at EPFL's School of Life Sciences.{{Cite web|title=Brexit: closer cooperation with the UK cannot replace participation in Horizon 2020 {{!}} ETH-Board|url=https://www.ethrat.ch/en/medien-medienmitteilungen/brexit-engere-zusammenarbeit-mit-grossbritannien-kann-teilnahme-horizon-2020-nicht-ersetzen|access-date=2020-12-21|website=www.ethrat.ch|archive-date=9 January 2021|archive-url=https://web.archive.org/web/20210109174027/https://www.ethrat.ch/en/medien-medienmitteilungen/brexit-engere-zusammenarbeit-mit-grossbritannien-kann-teilnahme-horizon-2020-nicht-ersetzen|url-status=dead}}{{Cite web|title=oateslab|url=https://www.epfl.ch/labs/oateslab/|access-date=2020-12-21|website=www.epfl.ch|language=en-GB}}{{Cite web|title=Andrew Charles Oates|url=https://people.epfl.ch/andrew.oates/?lang=en|access-date=2020-12-21|website=people.epfl.ch}} Since 2021, he has been dean of EPFL's School of Life Sciences.
Career
Oates received an undergraduate degree in biochemistry with honors for his work at the Robert Saint's laboratory at the University of Adelaide in 1992. He then joined Andrew F. Wilks at the Ludwig Institute for Cancer Research and at the University of Melbourne as PhD student, and graduated in 1998.{{Cite journal|last1=Nicholson|first1=S. E.|last2=Oates|first2=A. C.|last3=Harpur|first3=A. G.|last4=Ziemiecki|first4=A.|last5=Wilks|first5=A. F.|last6=Layton|first6=J. E.|date=1994-04-12|title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.|journal=Proceedings of the National Academy of Sciences|language=en|volume=91|issue=8|pages=2985–2988|doi=10.1073/pnas.91.8.2985|issn=0027-8424|pmc=43499|pmid=7512720|bibcode=1994PNAS...91.2985N |doi-access=free }} His postdoctoral time was at the laboratory of Robert Ho both at Princeton University and at University of Chicago, where he began his studies on the segmentation clock in zebrafish.{{Cite journal|last1=Oates|first1=Andrew C|last2=Bruce|first2=Ashley E.E|last3=Ho|first3=Robert K|date=August 2000|title=Too Much Interference: Injection of Double-Stranded RNA Has Nonspecific Effects in the Zebrafish Embryo|journal=Developmental Biology|language=en|volume=224|issue=1|pages=20–28|doi=10.1006/dbio.2000.9761|pmid=10898958|doi-access=free}} In 2003, he moved to the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden to start his research group.{{Cite journal|last1=Schröter|first1=Christian|last2=Herrgen|first2=Leah|last3=Cardona|first3=Albert|last4=Brouhard|first4=Gary J.|last5=Feldman|first5=Benjamin|last6=Oates|first6=Andrew C.|date=March 2008|title=Dynamics of zebrafish somitogenesis|journal=Developmental Dynamics|language=en|volume=237|issue=3|pages=545–553|doi=10.1002/dvdy.21458|pmid=18265021|s2cid=7038940|doi-access=free}}{{Cite journal|last1=Uriu|first1=Koichiro|last2=Ares|first2=Saúl|last3=Oates|first3=Andrew C.|last4=Morelli|first4=Luis G.|date=2013-03-21|title=Dynamics of mobile coupled phase oscillators|url=https://link.aps.org/doi/10.1103/PhysRevE.87.032911|journal=Physical Review E|language=en|volume=87|issue=3|pages=032911|doi=10.1103/PhysRevE.87.032911|bibcode=2013PhRvE..87c2911U |hdl=11336/2452 |issn=1539-3755|hdl-access=free}} In 2012, he became professor of vertebrate developmental genetics at University College London and moved his group to the National Institute for Medical Research at Mill Hill in London.{{Cite journal|last1=Soroldoni|first1=D.|last2=Jorg|first2=D. J.|last3=Morelli|first3=L. G.|last4=Richmond|first4=D. L.|last5=Schindelin|first5=J.|last6=Julicher|first6=F.|last7=Oates|first7=A. C.|date=2014-07-11|title=A Doppler effect in embryonic pattern formation|journal=Science|language=en|volume=345|issue=6193|pages=222–225|doi=10.1126/science.1253089|pmid=25013078|s2cid=206556621|issn=0036-8075|pmc=7611034|bibcode=2014Sci...345..222S }} In April 2015, he became a member of the Francis Crick Institute in London.{{Cite web|title=King's College London - Randall Seminar: Professor Andrew Oates|url=https://www.kcl.ac.uk/lsm/newsevents/eventrecords/2015/may/randall-seminar-professor-andrew-oates|access-date=2020-12-21|website=www.kcl.ac.uk}}
In 2016, he joined EPFL as a full professor, where he is the founder and director of the Timing, Oscillation, Patterns Laboratory at EPFL's School of Life Sciences.
Since 2018, he has served as director of the EPFL's Institute of Bioengineering,{{Cite journal|last=Sanctuary|first=Hillary|date=2020-08-25|title=Andrew Oates, a Passion for Cycles|url=https://actu.epfl.ch/news/andrew-oates-a-passion-for-cycles-2/|language=en}} and since January 2021 he has been the dean of the EPFL's School of Life Sciences.{{Cite journal|date=2020-11-12|title=New deans for the Basic Sciences and Life Sciences|url=https://actu.epfl.ch/news/new-deans-for-the-basic-sciences-and-life-sciences/|language=en}}
Research
Oates' research laboratory is composed of biologists, engineers, and physicists. It draws on molecular genetics, quantitative imaging, and theoretical analysis in order to investigate populations of coupled genetic oscillators in vertebrate embryos, termed as segmentation clocks.{{Cite journal|last1=Naganathan|first1=Sundar R.|last2=Oates|first2=Andrew C.|date=October 2017|title=Mechanochemical coupling and developmental pattern formation|url=https://linkinghub.elsevier.com/retrieve/pii/S2452310017300999|journal=Current Opinion in Systems Biology|language=en|volume=5|pages=104–111|doi=10.1016/j.coisb.2017.09.007|url-access=subscription}} These systems drive the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales.{{Cite web|title=Research|url=https://www.epfl.ch/labs/oateslab/page-141506-en-html/|access-date=2020-12-21|website=www.epfl.ch|language=en-GB}}{{Cite journal|last1=Lleras Forero|first1=Laura|last2=Narayanan|first2=Rachna|last3=Huitema|first3=Leonie FA|last4=VanBergen|first4=Maaike|last5=Apschner|first5=Alexander|last6=Peterson-Maduro|first6=Josi|last7=Logister|first7=Ive|last8=Valentin|first8=Guillaume|last9=Morelli|first9=Luis G|last10=Oates|first10=Andrew C|last11=Schulte-Merker|first11=Stefan|date=2018-04-06|editor-last=Whitfield|editor-first=Tanya T.|title=Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock|journal=eLife|volume=7|pages=e33843|doi=10.7554/eLife.33843|pmid=29624170|pmc=5962341|s2cid=4605280|issn=2050-084X|doi-access=free}}
The laboratory' contributions are the direct connection of genes to segmentation rhythm, and the discovery that the rhythm also involves physical, collective processes at multi-cellular and tissue scales.{{Cite journal|last=Oates|first=Andrew C|date=August 2020|title=Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks|journal=Current Opinion in Genetics & Development|language=en|volume=63|pages=61–70|doi=10.1016/j.gde.2020.04.008|pmid=32505051|doi-access=free}}{{Cite journal|last1=Venzin|first1=Olivier F.|last2=Oates|first2=Andrew C.|date=April 2020|title=What are you synching about? Emerging complexity of Notch signaling in the segmentation clock|journal=Developmental Biology|language=en|volume=460|issue=1|pages=40–54|doi=10.1016/j.ydbio.2019.06.024|pmid=31302101|doi-access=free}}
Distinctions
Oates is a member of the British Society of Developmental Biology.{{Cite web|last=|first=|date=|title=Newsletter|url=http://bsdb.org/wp-content/uploads/BSDB-Newsletter-2015-12b.pdf|archive-url=|archive-date=|access-date=|website=British Society for Developmental Biology}} He is the recipient of the R.K. Mortenson Prize for Biochemistry 1991.
Selected works
- {{cite journal |doi=10.1103/PhysRevE.99.042417|title=Embryonic lateral inhibition as optical modes: An analytical framework for mesoscopic pattern formation|year=2019|last1=Negrete|first1=Jose|last2=Oates|first2=Andrew C.|journal=Physical Review E|volume=99|issue=4|page=042417|pmid=31108612|arxiv=1808.09362 |bibcode=2019PhRvE..99d2417N |s2cid=104644290|doi-access=free}}
- {{cite journal |doi=10.7554/eLife.33843|title=Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock|year=2018|last1=Lleras Forero|first1=Laura|last2=Narayanan|first2=Rachna|last3=Huitema|first3=Leonie FA|last4=Vanbergen|first4=Maaike|last5=Apschner|first5=Alexander|last6=Peterson-Maduro|first6=Josi|last7=Logister|first7=Ive|last8=Valentin|first8=Guillaume|last9=Morelli|first9=Luis G.|last10=Oates|first10=Andrew C.|last11=Schulte-Merker|first11=Stefan|journal=eLife|volume=7|pmid=29624170|pmc=5962341 |doi-access=free }}
- {{cite journal |doi=10.1038/s41467-017-01469-5|title=Small molecule screen in embryonic zebrafish using modular variations to target segmentation|year=2017|last1=Richter|first1=Sandra|last2=Schulze|first2=Ulrike|last3=Tomançak|first3=Pavel|last4=Oates|first4=Andrew C.|journal=Nature Communications|volume=8|issue=1|page=1901|pmid=29196645|pmc=5711842|bibcode=2017NatCo...8.1901R }}
- {{cite journal |doi=10.1038/ncomms11861|title=Faster embryonic segmentation through elevated Delta-Notch signalling|year=2016|last1=Liao|first1=Bo-Kai|last2=Jörg|first2=David J.|last3=Oates|first3=Andrew C.|journal=Nature Communications|volume=7|page=11861|pmid=27302627|pmc=4912627|bibcode=2016NatCo...711861L }}
- {{cite journal |doi=10.7554/eLife.08438|title=Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock|year=2016|last1=Webb|first1=Alexis B.|last2=Lengyel|first2=Iván M.|last3=Jörg|first3=David J.|last4=Valentin|first4=Guillaume|last5=Jülicher|first5=Frank|last6=Morelli|first6=Luis G.|last7=Oates|first7=Andrew C.|journal=eLife|volume=5|pmid=26880542|pmc=4803185 |doi-access=free }}
- {{cite journal |doi=10.1126/science.1253089|title=A Doppler effect in embryonic pattern formation|year=2014|last1=Soroldoni|first1=D.|last2=Jorg|first2=D. J.|last3=Morelli|first3=L. G.|last4=Richmond|first4=D. L.|last5=Schindelin|first5=J.|last6=Julicher|first6=F.|last7=Oates|first7=A. C.|journal=Science|volume=345|issue=6193|pages=222–225|pmid=25013078|s2cid=206556621|pmc=7611034|bibcode=2014Sci...345..222S }}
- {{cite journal |doi=10.1242/dev.093435|title=WNT-regulated dynamics of positional information in zebrafish somitogenesis|year=2014|last1=Bajard|first1=L.|last2=Morelli|first2=L. G.|last3=Ares|first3=S.|last4=Pecreaux|first4=J.|last5=Julicher|first5=F.|last6=Oates|first6=A. C.|journal=Development|volume=141|issue=6|pages=1381–1391|pmid=24595291|pmc=3943186}}
- {{cite journal |doi=10.1371/journal.pbio.1001364|title=Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit|year=2012|last1=Schröter|first1=Christian|last2=Ares|first2=Saúl|last3=Morelli|first3=Luis G.|last4=Isakova|first4=Alina|last5=Hens|first5=Korneel|last6=Soroldoni|first6=Daniele|last7=Gajewski|first7=Martin|last8=Jülicher|first8=Frank|last9=Maerkl|first9=Sebastian J.|last10=Deplancke|first10=Bart|last11=Oates|first11=Andrew C.|journal=PLOS Biology|volume=10|issue=7|pages=e1001364|pmid=22911291|pmc=3404119 |doi-access=free }}
References
{{reflist}}
External links
- {{Google Scholar id|id=KaeLngQAAAAJ}}
- Website of the [https://www.epfl.ch/labs/oateslab/ Segmentation Timing and Dynamics Laboratory]
{{Authority control}}
{{DEFAULTSORT:Oates, Andrew Charles}}
Category:Academic staff of the École Polytechnique Fédérale de Lausanne
Category:University of Adelaide alumni
Category:University of Melbourne alumni
Category:21st-century biochemists