Angela Koehler
{{Short description|American biochemist and academic}}
{{Infobox scientist
| name = Angela Nicole Koehler
| workplaces = California Institute of Technology
Harvard University
Broad Institute
| alma_mater = Harvard University
Reed College
| thesis_title = Small molecule microarrays: A high-throughput tool for discovering protein-small molecule interactions
| thesis_url = https://www.proquest.com/openview/a60083f8326825cd59a7d5642167f838/1?pq-origsite=gscholar&cbl=18750&diss=y
| thesis_year = 2003
| doctoral_advisor = Stuart Schreiber
}}
Angela N. Koehler is an American biochemist who is the Karl Van Tassel (1925) Career Development Professor of Chemical Biology at the Broad Institute. Her research considers the development of chemical tools to understand transcriptional regulation, and the design of next-generation pharmaceuticals.
Early life and education
Koehler was an undergraduate student in biochemistry at Reed College.{{Cite web |last=alan |title=Alumni News from Reed Magazine, March '13 {{!}} Chemistry News |url=https://blogs.reed.edu/chemistry_news/2014/05/alumni-news-from-reed-magazine-march-13/ |access-date=2022-10-15 |language=en-US}} She worked on structural studies of proteins that recognize nucleic acids, including transfer RNA and DNA.{{Cite web |title=Angela Koehler, PhD {{!}} MIT Department of Biological Engineering |url=https://be.mit.edu/directory/angela-koehler |access-date=2022-10-15 |website=be.mit.edu |language=en}} She moved to Harvard University as a doctoral researcher, where she worked alongside Stuart Schreiber on strategies to understand the interactions between proteins and molecules.{{cn|date=October 2022}}
Research and career
Koehler joined the chemical biology program at the Broad Institute, where she was made group leader for chemical genetics.{{when?|date=October 2022}}{{cn|date=October 2022}} Koehler develops time-sensitive chemical tools to understand the dynamics of transcriptional regulation. Before the work of Koehler it was understood that transcription factors were "undruggable", as their inherent structural disorder compromised the binding of small-molecule ligands.{{Cite journal |last1=Henley |first1=Matthew J. |last2=Koehler |first2=Angela N. |date=September 2021 |title=Advances in targeting 'undruggable' transcription factors with small molecules |url=https://pubmed.ncbi.nlm.nih.gov/34006959/ |journal=Nature Reviews. Drug Discovery |volume=20 |issue=9 |pages=669–688 |doi=10.1038/s41573-021-00199-0 |issn=1474-1784 |pmid=34006959|s2cid=234780718 }} Her research looks to develop small-molecule probes{{Cite web |date=2019-01-23 |title=Angela Koehler |url=https://www.broadinstitute.org/bios/angela-koehler |access-date=2022-10-15 |website=Broad Institute |language=en}} that modify proteins, which can, in turn, tune gene expression.{{Cite web |title=Angela Koehler (MIT) {{!}} Target 2035 |url=https://www.target2035.net/biosketches/angela-koehler-mit |access-date=2022-10-15 |website=www.target2035.net}}
Koehler is on the faculty at the Koch Institute for Integrative Cancer Research.{{Cite web |date=2013-11-22 |title=Broad announces new Merkin Institute Fellows |url=https://www.broadinstitute.org/blog/broad-announces-new-merkin-institute-fellows |access-date=2022-10-15 |website=Broad Institute |language=en}} She has founded several companies, including Ligon Discovery, a drug discovery company focused on small-molecule microarrays, Kronos Bio,{{Cite web |title=Angela Koehler, Ph.D.|url=https://www.kronosbio.com/biographies/angela-koehler-bio/|access-date=2022-10-16 |website=Kronos Bio}}{{Cite journal |last=Ryan Cross |date=2018-11-05 |title=Kronos Bio |url=https://pubs.acs.org/doi/abs/10.1021/cen-09644-cover6 |journal=C&EN Global Enterprise |language=en |volume=96 |issue=44 |pages=38–39 |doi=10.1021/cen-09644-cover6 |s2cid=239821660 |issn=2474-7408|doi-access=free }} a cancer therapeutics accelerator and 76Bio,{{Cite web |title=Home - 76bio |url=https://www.76bio.com/ |access-date=2022-10-15 |language=en-US}} a biotechnology company that looks to develop targeted protein degraders.
Awards and honors
- Genome Technology Young Investigator{{Cite web |date=2012-12-03 |title=Angela Koehler: The Small Molecule World |url=https://www.genomeweb.com/clinical-genomics/angela-koehler-small-molecule-world |access-date=2022-10-15 |website=GenomeWeb |language=en}}
- Broad Institute Merkin Fellow
- Novartis Lectureship in Chemistry{{Cite web |title=HBC Research Seminar October 2020 |url=https://hbc.ku.edu/hbc-research-seminar-october-2020 |access-date=2022-10-15 |website=hbc.ku.edu |language=en}}
- Ono Pharma Breakthrough Science Award{{Cite web |title=ONO PHARMA FOUNDATION |url=https://www.grantmakers.io/profiles/v0/815299703-ono-pharma-foundation/ |access-date=2022-10-15 |website=Grantmakers.io |language=en}}
- Fellow of the National Academy of Sciences{{Cite web |title=Angela Koehler |url=http://www.nasonline.org/programs/kavli-frontiers-of-science/frontiers-alumni/alumni-directory/angela-koehler.html |access-date=2022-10-15 |website=www.nasonline.org}}
- National Science Foundation CAREER Award{{Cite web |title=NSF Award Search: Award # 1845464 - CAREER: Reprogramming Transcriptional Regulation by Chemical Stabilization of Repressive Homodimers |url=https://www.nsf.gov/awardsearch/showAward?AWD_ID=1845464 |access-date=2022-10-15 |website=www.nsf.gov}}
- MIT Junior Bose Award for Excellence in Teaching{{Cite web |title=MIT School of Engineering {{!}} » Teaching Awards |url=https://engineering.mit.edu/faculty-research/faculty-awards/teaching-awards/ |access-date=2022-10-15 |website=Mit Engineering |language=en-US}}
Selected publications
- {{Cite Q|Q24322974}}
- {{Cite Q|Q24646445}}
References
{{Reflist}}
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Category:Harvard Graduate School of Arts and Sciences alumni
Category:Massachusetts Institute of Technology faculty
Category:American women biochemists
Category:Broad Institute people