Angiopoietin 1

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.{{cite journal | vauthors = Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG | title = Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats | journal = J. Biol. Chem. | volume = 278 | issue = 3 | pages = 1721–1727 | date = Jan 2003 | pmid = 12427764 | doi = 10.1074/jbc.M208550200 | location = United States | issn = 0021-9258 | doi-access = free }}{{cite journal | vauthors = Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD | title = Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning | journal = Cell | volume = 87 | issue = 7 | pages = 1161–1169 | date = Dec 1996 | pmid = 8980223 | doi = 10.1016/S0092-8674(00)81812-7 | location = United States | issn = 0092-8674 | s2cid = 17197564 | doi-access = free }}{{cite journal | vauthors = Sato A | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = Int. Immunol. | volume = 10 | issue = 8 | pages = 1217–1227 | date = Aug 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 | location = ENGLAND | issn = 0953-8178 | doi-access = free }}{{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | date = Jul 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 | location = UNITED STATES | issn = 0036-8075 }}

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria).{{Cite journal | vauthors = Ataíde R, Murillo O, Dombrowski JG, Souza RM, Lima FA, Lima GF, Hristov AD, Valle SC, Santi SM | title = Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta | journal = PLOS Neglected Tropical Diseases | volume = 9 | issue = 6 | pages = e0003824 | date = 2015-06-19 | pmid = 26090803 | pmc = 4475015 | doi = 10.1371/journal.pntd.0003824 | issn = 1935-2735 | doi-access = free }} In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.{{Cite journal | vauthors = Silver KL, Zhong K, Leke RG, Taylor DW, Kain KC | title = Dysregulation of angiopoietins is associated with placental malaria and low birth weight | journal = PLOS ONE | volume = 5 | issue = 3 | pages = e9481 | date = 2010-03-01 | pmid = 20208992 | pmc = 2830425 | doi = 10.1371/journal.pone.0009481 | issn = 1932-6203 | bibcode = 2010PLoSO...5.9481S | doi-access = free }} This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

• Angiopoietin

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
• {{cite journal | vauthors = Metheny-Barlow LJ, Li LY | title = The enigmatic role of angiopoietin-1 in tumor angiogenesis | journal = Cell Res. | volume = 13 | issue = 5 | pages = 309–317 | year = 2004 | pmid = 14672554 | doi = 10.1038/sj.cr.7290176 | doi-access = free }}
• {{cite journal | vauthors = Makinde T, Murphy RF, Agrawal DK | title = Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling | journal = Curr. Mol. Med. | volume = 6 | issue = 8 | pages = 831–841 | year = 2007 | pmid = 17168735 | doi = 10.2174/156652406779010795 }}
• {{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 | journal = DNA Res. | volume = 1 | issue = 1 | pages = 27–35 | year = 1995 | pmid = 7584026 | doi = 10.1093/dnares/1.1.27 | doi-access = free }}
• {{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) | journal = DNA Res. | volume = 1 | issue = 1 | pages = 47–56 | year = 1995 | pmid = 7584028 | doi = 10.1093/dnares/1.1.47 | doi-access = free }}
• {{cite journal | vauthors = Rüegg C, Pytela R | title = Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein | journal = Gene | volume = 160 | issue = 2 | pages = 257–262 | year = 1995 | pmid = 7642106 | doi = 10.1016/0378-1119(95)00240-7 }}
• {{cite journal | vauthors = Davis S, Aldrich TH, Jones PF | title = Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning | journal = Cell | volume = 87 | issue = 7 | pages = 1161–1169 | year = 1997 | pmid = 8980223 | doi = 10.1016/S0092-8674(00)81812-7 | s2cid = 17197564 | doi-access = free }}
• {{cite journal | vauthors = Suri C, Jones PF, Patan S | title = Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis | journal = Cell | volume = 87 | issue = 7 | pages = 1171–1180 | year = 1997 | pmid = 8980224 | doi = 10.1016/S0092-8674(00)81813-9 | s2cid = 15926708 | doi-access = free }}
• {{cite journal | vauthors = Maisonpierre PC, Suri C, Jones PF | title = Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis | journal = Science | volume = 277 | issue = 5322 | pages = 55–60 | year = 1997 | pmid = 9204896 | doi = 10.1126/science.277.5322.55 }}
• {{cite journal | vauthors = Ristimäki A, Narko K, Enholm B | title = Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 8413–8418 | year = 1998 | pmid = 9525952 | doi = 10.1074/jbc.273.14.8413 | doi-access = free }}
• {{cite journal | vauthors = Cheung AH, Stewart RJ, Marsden PA | title = Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23 | journal = Genomics | volume = 48 | issue = 3 | pages = 389–391 | year = 1998 | pmid = 9545648 | doi = 10.1006/geno.1997.5207 }}
• {{cite journal | vauthors = Witzenbichler B, Maisonpierre PC, Jones P | title = Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2 | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18514–18521 | year = 1998 | pmid = 9660821 | doi = 10.1074/jbc.273.29.18514 | doi-access = free }}
• {{cite journal | vauthors = Sato A, Iwama A, Takakura N | title = Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells | journal = Int. Immunol. | volume = 10 | issue = 8 | pages = 1217–1227 | year = 1998 | pmid = 9723709 | doi = 10.1093/intimm/10.8.1217 | doi-access = free }}
• {{cite journal | vauthors = Valenzuela DM, Griffiths JA, Rojas J | title = Angiopoietins 3 and 4: diverging gene counterparts in mice and humans | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 5 | pages = 1904–1909 | year = 1999 | pmid = 10051567 | pmc = 26709 | doi = 10.1073/pnas.96.5.1904 | bibcode = 1999PNAS...96.1904V | doi-access = free }}
• {{cite journal | vauthors = Grosios K, Leek JP, Markham AF | title = Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping | journal = Cytogenet. Cell Genet. | volume = 84 | issue = 1–2 | pages = 118–120 | year = 1999 | pmid = 10343124 | doi = 10.1159/000015235 | s2cid = 40232421 }}
• {{cite journal | vauthors = Procopio WN, Pelavin PI, Lee WM, Yielding NM | title = Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30196–30201 | year = 1999 | pmid = 10514510 | doi = 10.1074/jbc.274.42.30196 | doi-access = free }}
• {{cite journal | vauthors = Huang YQ, Li JJ, Karpatkin S | title = Identification of a family of alternatively spliced mRNA species of angiopoietin-1 | journal = Blood | volume = 95 | issue = 6 | pages = 1993–1999 | year = 2000 | pmid = 10706866 | doi = 10.1182/blood.V95.6.1993 | s2cid = 34946654 }}
• {{cite journal | vauthors = Kim I, Kim JH, Ryu YS | title = Characterization and expression of a novel alternatively spliced human angiopoietin-2 | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18550–18556 | year = 2000 | pmid = 10766762 | doi = 10.1074/jbc.M910084199 | doi-access = free }}
• {{cite journal | vauthors = Dunk C, Shams M, Nijjar S | title = Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development | journal = Am. J. Pathol. | volume = 156 | issue = 6 | pages = 2185–2199 | year = 2000 | pmid = 10854239 | pmc = 1850068 | doi = 10.1016/S0002-9440(10)65089-4 }}
• {{cite journal | vauthors = Krikun G, Schatz F, Finlay T | title = Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation | journal = Biochem. Biophys. Res. Commun. | volume = 275 | issue = 1 | pages = 159–163 | year = 2000 | pmid = 10944458 | doi = 10.1006/bbrc.2000.3277 | doi-access = free }}

{{refend}}

• {{UCSC gene info|ANGPT1}}

{{NLM content}}

{{Angiogenic_proteins}}

{{Growth factor receptor modulators}}