Anion exchange transporter
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.{{cite journal | vauthors = Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J | title = Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 14246–54 | date = April 2002 | pmid = 11834742 | doi = 10.1074/jbc.M111802200 | doi-access = free }}{{cite journal | vauthors = Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP | title = Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney | journal = Genomics | volume = 79 | issue = 2 | pages = 249–56 | date = February 2002 | pmid = 11829495 | doi = 10.1006/geno.2002.6689 }}{{cite journal | vauthors = Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M | title = Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion | journal = Journal of the American Society of Nephrology | volume = 17 | issue = 4 | pages = 956–67 | date = April 2006 | pmid = 16524946 | doi = 10.1681/ASN.2005111174 | doi-access = free | pmc = 11627242 }}{{cite web | title = Entrez Gene: SLC26A7 solute carrier family 26, member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115111}}
Function
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.
See also
References
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Further reading
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- {{cite journal | vauthors = Markovich D | title = Physiological roles and regulation of mammalian sulfate transporters | journal = Physiological Reviews | volume = 81 | issue = 4 | pages = 1499–533 | date = October 2001 | pmid = 11581495 | doi = 10.1152/physrev.2001.81.4.1499| s2cid = 30942862 }}
- {{cite journal | vauthors = Petrovic S, Ju X, Barone S, Seidler U, Alper SL, Lohi H, Kere J, Soleimani M | title = Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 284 | issue = 6 | pages = G1093–103 | date = June 2003 | pmid = 12736153 | doi = 10.1152/ajpgi.00454.2002 }}
- {{cite journal | vauthors = Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M | title = SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct | journal = American Journal of Physiology. Renal Physiology | volume = 286 | issue = 1 | pages = F161–9 | date = January 2004 | pmid = 12965893 | doi = 10.1152/ajprenal.00219.2003 | s2cid = 25003214 }}
- {{cite journal | vauthors = Barone S, Amlal H, Xu J, Kujala M, Kere J, Petrovic S, Soleimani M | title = Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct | journal = Journal of the American Society of Nephrology | volume = 15 | issue = 8 | pages = 2002–11 | date = August 2004 | pmid = 15284286 | doi = 10.1097/01.ASN.0000135060.83250.07 | doi-access = free }}
- {{cite journal | vauthors = Kujala M, Tienari J, Lohi H, Elomaa O, Sariola H, Lehtonen E, Kere J | title = SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney | journal = Nephron Experimental Nephrology | volume = 101 | issue = 2 | pages = e50–8 | year = 2006 | pmid = 15956810 | doi = 10.1159/000086345 | s2cid = 26671784 }}
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{{NLM content}}
{{Membrane transport proteins}}
Category:Solute carrier family
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