Ann E. Weber

Weber grew up in Oshkosh, Wisconsin, the child of a nurse and a doctor.{{cite web|last1=Schmidt|first1=Christine Brennan|title=WCC Merck Research Award - WCC Luncheon Address – Diversity and Me, My Life as a Woman in Chemistry|url=https://communities.acs.org/groups/wcc-newsletter/blog/2017/05/30/wcc-merck-research-award-wcc-luncheon-address-diversity-and-me-my-life-as-a-woman-in-chemistry|website=WCC Newsletter|publisher=American Chemical Society|accessdate=9 October 2017}}{{cite news|title=Frances Weber (Obituary)|url=http://www.legacy.com/obituaries/thenorthwestern/obituary.aspx?pid=171274125|accessdate=9 October 2017|work=Oshkosh Northwestern|date=June 10, 2014}}

There she attended Lourdes High School (Oshkosh, Wisconsin), a Catholic school.

Weber earned a B.S. degree in chemistry summa cum laude from the University of Notre Dame (1982).{{cite web|title=Alumni Profile: Ann E. Weber '82|url=http://science.nd.edu/alumni/alumni-profile-ann-e-weber-82/|website=University of Notre Dame|accessdate=9 October 2017|archive-date=25 September 2020|archive-url=https://web.archive.org/web/20200925010135/https://science.nd.edu/alumni/alumni-profile-ann-e-weber-82/|url-status=dead}} She also was able to attend Caltech for a year (1982-1983). Ann Weber took part in a summer internship for Monsanto from June 1982-August 1982 where she studied the synthesis of novel herbicides for crop protection. https://urldefense.com/v3/__https://www.linkedin.com/in/ann-weber-2b97829__;!!KwNVnqRv!CfSlrr6UN7iZRRAxctO1Hn7e65hY_aeZ9U-erHWIaFkcFuJCCCgQ8ItJTHGRdpECg_zqsayCjV-27fNpOWXADs6mw9-Ci0c$ To complete her education, Ann received a Ph.D. degree from Harvard University, where she studied synthetic organic chemistry with David A. Evans.{{cite news|title=News from SCI America: Perkin Medal to be awarded to Dr. Ann E. Weber|url=http://www.soci.org/news/awards/perkin/awards-perkin-ann-weber|accessdate=9 October 2017|work=SCI America|date=31 May 2017}} She was the first woman to receive a Ph.D. from his group, in 1987.{{cite journal|title=WOMEN IN CHEMISTRY CHOOSING TO SUCCEED Medicinal chemist Ann Weber's path has led her to a fulfilling career in industry|url=http://pubs.acs.org/cen/women/8021/8021bus3.html|accessdate=9 October 2017|journal=Chemical & Engineering News|page=28|volume=80|issue=21|date=May 27, 2002|doi=10.1021/cen-v080n021.p028|url-access=subscription}}

Weber joined Merck Research Laboratories (MRL) in Rahway, New Jersey, in 1987, retiring in 2015 from the position of vice president for lead optimization chemistry. In 2016 she joined Kallyope Inc. in New York City as senior vice president for drug discovery.{{cite news|title=Kallyope Inc. Appoints Ann E. Weber And William J. Rieflin To Key Roles|url=https://www.prnewswire.com/news-releases/kallyope-inc-appoints-ann-e-weber-and-william-j-rieflin-to-key-roles-300352078.html|accessdate=16 October 2017|work=Cision|date=Oct 27, 2016}} Her research areas include the development of ligands for G protein–coupled receptors, Ligand-gated ion channels and enzymes.

During her career in drug discovery and development, she has published more than 80 publications. She is a co-inventor of more than 35 issued US patents. Her work has led to the development of more than 40 drug candidates including FDA-approved treatments for Type 2 diabetes.{{cite web|title= Ann E. Weber, PhD|url=https://www.acsmedchem.org/?nd=weber|website=ACS Division of Medicinal Chemistry|accessdate=9 October 2017}} Other drug candidates target obesity, atherosclerosis, pain, and urinary incontinence.

Beginning in 1999, Weber led the chemical team for the development of Januvia (generic: sitagliptin), a drug that inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme and improves glucose tolerance to treat Type 2 diabetes. Nancy Thornberry led the corresponding biological team for the project.{{cite book|last1=Cordes|first1=Eugene H.|title=Hallelujah moments : tales of drug discovery|date=2014|publisher=Oxford University Press|location=Oxford, UK|isbn=9780199337149|pages=207–|url=https://books.google.com/books?id=lG2JAgAAQBAJ&pg=PA207|accessdate=9 October 2017}}{{cite news|last1=Wolfe|first1=Josh|title=Harnessing The Gut-Brain Axis|url=https://www.forbes.com/sites/joshwolfe/2016/06/28/harnessing-the-gut-brain-axis/|accessdate=9 October 2017|work=Forbes|date=June 28, 2016}} The drug was approved by the FDA in October 2006. Janumet, a drug combining sitagliptin and metformin was also approved, in April 2007. In 2007, the research team at Merck received the Prix Galien USA award for their work on Januvia.{{cite news|last1=Stowe|first1=Gene|title=Distinguished alumna lecture is like a "mini course in medicinal chemistry"|url=http://science.nd.edu/news/distinguished-alumna-lecture-is-like-a-mini-course-in-medicinal-chemistry-2/|accessdate=9 October 2017|work=University of Notre Dame News|date=April 10, 2008}}

• 2017, Perkin Medal, Society of Chemical Industry (American Section){{cite web|title=SCI Perkin Medal|url=https://www.sciencehistory.org/sci-perkin-medal|website=Science History Institute|accessdate=24 March 2018|date=2016-05-31}}{{cite news|title=Perkin Medal|url=http://sci-america.org/site/?page_id=68|accessdate=9 October 2017|work=SCI America}}
• 2016, MEDI Hall of Fame, ACS Division of Medicinal Chemistry{{cite news|last1=Freehling|first1=Tammi|title=Chemistry alumna, Ann Weber '82, inducted into MEDI Hall of Fame|url=http://science.nd.edu/news/distinguished-alumna-lecture-is-like-a-mini-course-in-medicinal-chemistry-2/|accessdate=9 October 2017|work=University of Notre Dame News|date=October 18, 2016}}
• 2013, Women in STEM honoree, Liberty Science Center (LSC){{cite web|title=Women in STEM honored at LSC annual luncheon|website=LSC News|publisher=Liberty Science Center|url=https://lsc.org/news-and-social/news/women-in-stem-honored-at-lsc-annual-luncheon|date=December 11, 2013}}
• 2012-2013, Sylvia M. Stoesser Lecturer in Chemistry, University of Illinois{{cite web |title=Sylvia M. Stoesser Lecturer 2012-13 -Ann E. Weber |url=https://chemistry.illinois.edu/sylvia-m-stoesser-lecturer-2012-13-ann-e-weber |website=University of Illinois at Urbana-Champaign |accessdate=27 June 2019}}
• 2011, Discoverer’s Award, Pharmaceutical Research and Manufacturers of America (PhRMA), with Nancy Thornberry{{cite news|title=Women Scientists Honored For New Diabetes Oral Medication|url=http://www.phrma.org/press-release/two-women-scientists-honored-with-discoverers-award-for-first-new-oral-medication-for-diabetes-in-over-a-decade|accessdate=9 October 2017|work=PhRMA|date=April 14, 2011|archive-url=https://web.archive.org/web/20180517082046/https://www.phrma.org/press-release/two-women-scientists-honored-with-discoverers-award-for-first-new-oral-medication-for-diabetes-in-over-a-decade|archive-date=17 May 2018|url-status=dead}}
• 2011, Thomas Alva Edison Patent Award, Research and Development Council of New Jersey{{cite news|title=Industry Researchers Honored with Coveted Thomas Alva Edison Patent Award|url=http://hinj.org/industry-researchers-honored-with-coveted-thomas-alva-edison-patent-award/|accessdate=16 October 2017|work=HealthCare Institute of New Jersey|date=November 16, 2011}}
• 2010, Heroes of Chemistry Award (ACS) with Nancy Thornberry and Joseph Armstrong{{cite web|title=New Heroes of Chemistry invented medicines that help millions of people|url=https://www.acs.org/content/acs/en/pressroom/presspacs/2010/acs-presspac-august-19-2010/new-heroes-of-chemistry-invented-medicines-that-help-millions-of-people.html|website=American Chemical Society|accessdate=August 19, 2010}}{{cite web|title=Heroes of Chemistry Award|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/industry/heroes/recipients.html|website=American Chemical Society|accessdate=9 October 2017}}
• 2010, Robert M. Scarborough Award for Excellence in Medicinal Chemistry, American Chemistry Society (ACS){{cite news|last1=Gebhard|first1=Marissa|title=Ann Weber '82 wins Scarborough Memorial Award|url=http://science.nd.edu/news/ann-weber-82-wins-scarborough-memorial-award/|accessdate=9 October 2017|work=University of Notre Dame News|date=June 9, 2010}}
• 2008, Outstanding Women of Science honoree, New Jersey Association for Biomedical Research (NJABR){{cite web|title=Recognizing Outstanding Women of Science|url=http://www.weinerandassociates.biz/sitebuildercontent/sitebuilderfiles/NJOwomenS.pdf|website=Weiner and Associates|date=May 1, 2008|access-date=October 9, 2017|archive-url=https://web.archive.org/web/20130512131255/http://www.weinerandassociates.biz/sitebuildercontent/sitebuilderfiles/NJOwomenS.pdf|archive-date=May 12, 2013|url-status=dead}}
• 2007, Prix Galien USA award to the Merck research team for Januvia{{cite web|title=Discovery of the Decade|url=http://candidates.prix-galien-usa.com/docs/Discovery.pdf|website=The Prix Galien USA Awards|accessdate=9 October 2017}}
• Merck & Co. Director’s Award, the highest honor that Merck confers on its employees{{cite news|last1=Lucero|first1=Sam|title=Chemist mixes up generous donation to school Lourdes High School grad gives $25,000 education grant to alma mater|url=https://www.thecompassnews.org/compass/2008-02-22/news3.shtml|accessdate=9 October 2017|work=The Compass|date=February 22, 2008}}

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Category:Living people

Category:Notre Dame College of Arts and Letters alumni

Category:Harvard Graduate School of Arts and Sciences alumni

Category:21st-century American chemists

Category:American women chemists

Category:Year of birth missing (living people)

Category:21st-century American women scientists