Anne Moscona
{{Short description|American virologist}}
{{Use dmy dates|date=July 2022}}
{{Infobox scientist
| name = Anne Moscona
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| birth_place = Chicago, Illinois, U.S.
| workplaces = {{ubl|Mount Sinai Medical Center|Weill Cornell Medical Center|Columbia University Medical Center}}
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Anne Moscona is an American virologist and pediatrician. Her research has identified cell entry mechanisms for enveloped respiratory viruses,{{Cite web |date=2018-10-01 |title=Moscona Lab |url=https://www.pediatrics.columbia.edu/research-labs/moscona-lab |access-date=2022-07-07 |website=Department of Pediatrics |language=en}} with applications to parainfluenza virus, Nipah virus, measles virus, and other viruses, and has applied this knowledge to the development of antiviral strategies to prevent infection by viruses including SARS-CoV-2.{{Cite journal |last1=de Vries |first1=Rory D. |last2=Schmitz |first2=Katharina S. |last3=Bovier |first3=Francesca T. |last4=Predella |first4=Camilla |last5=Khao |first5=Jonathan |last6=Noack |first6=Danny |last7=Haagmans |first7=Bart L. |last8=Herfst |first8=Sander |last9=Stearns |first9=Kyle N. |last10=Drew-Bear |first10=Jennifer |last11=Biswas |first11=Sudipta |date=2021-03-26 |title=Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets |journal=Science |language=en |volume=371 |issue=6536 |pages=1379–1382 |doi=10.1126/science.abf4896 |issn=0036-8075 |pmc=8011693 |pmid=33597220|bibcode=2021Sci...371.1379D }} Since 2016, she has served as the Sherie L. Morrison Professor of Microbiology & Immunology, Professor of Pediatrics, and Professor of Physiology & Cellular Biophysics at Columbia University Medical Center in New York City, where she also directs the Center for Host Pathogen Interaction.{{Cite web |date=2018-10-11 |title=Anne Moscona, MD |url=https://www.pediatrics.columbia.edu/profile/anne-moscona-md |access-date=2022-07-07 |website=Department of Pediatrics |language=en}}{{Cite web |date=2020-07-21 |title=Center for Host-Pathogen Interaction |url=https://www.pediatrics.columbia.edu/about-us/divisions/critical-care-and-hospital-medicine/center-host-pathogen-interaction |access-date=2022-07-07 |website=Department of Pediatrics |language=en}} In 2022, Moscona was elected as president of the American Society for Virology, the nation's leading virology research organization.{{Cite web |date=2022-06-14 |title=Columbia Virologist-Pediatrician to Lead Nation's Leading Virus Research Organization |url=https://www.cuimc.columbia.edu/news/columbia-virologist-pediatrician-lead-nations-leading-virus-research-organization |access-date=2022-07-07 |website=Columbia University Irving Medical Center |language=en}}
Early life and education
Moscona was born in Chicago, Illinois, where her parents, Aron Moscona{{Cite journal |last=Mahowald |first=Anthony P. |date=2014 |title=Aron Moscona 1929-2009 |url=http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/moscona-aron.pdf |journal=National Academy of Sciences}}{{Cite news |last=McNeil |first=Donald G. Jr. |date=2009-01-26 |title=Aron Moscona, 87, Biologist Who Explored Embryonic Cells, Dies |language=en-US |work=The New York Times |url=https://www.nytimes.com/2009/01/26/nyregion/26moscona.html |access-date=2022-07-07 |issn=0362-4331}} and Malka Moscona,{{Cite web |title=Moscona, Malka : Photographic Archive : The University of Chicago |url=http://photoarchive.lib.uchicago.edu/db.xqy?one=apf1-12683.xml |access-date=2022-07-07 |website=photoarchive.lib.uchicago.edu}} were Israeli-American developmental biologists at the University of Chicago.{{Cite web |title=Aron A Moscona PhD 1921-2009 |url=https://www.uchicagomedicine.org/forefront/news/aron-a-moscona-phd-1921-2009 |access-date=2022-07-07 |website=www.uchicagomedicine.org |language=en}}{{Cite web |title=Aron A. Moscona, PhD, 1921-2009 |url=https://news.uchicago.edu/story/aron-moscona-phd-1921-2009 |access-date=2022-07-08 |website=news.uchicago.edu |date=26 January 2009 |language=en}} Moscona received her BA in Molecular Biology & Biochemistry from Harvard University in 1978, and MD from Columbia University College of Physicians and Surgeons in 1982.{{Cite web |date=2018-10-11 |title=Anne Moscona, MD |url=https://www.pediatrics.columbia.edu/profile/anne-moscona-md |access-date=2022-07-07 |website=Department of Pediatrics |language=en}}
Career
Moscona completed her clinical and research training at Mount Sinai Health System in New York City. She was promoted to tenured professor in 2001 and served as chief of pediatric infectious diseases and vice chair for research until 2005. In 2005, she became professor of Pediatrics and of Microbiology and Immunology, vice chair for research of Pediatrics, and Chief of Pediatric Infectious Diseases at the Weill Cornell Medical Center,{{Cite journal |last=Moscona |first=Anne |date=2009-10-30 |title=Invited Speaker |url=https://idsa.confex.com/idsa/2009/webprogram/Paper28498.html |language=English |publisher=Idsa}} before moving to Columbia in 2015 as a tri-departmental professor and center director. Moscona's research focuses on understanding how viruses enter human cells and how to use this knowledge to design better tools to prevent viral infection.{{Cite web |date=2018-10-01 |title=Moscona Lab |url=https://www.pediatrics.columbia.edu/research-labs/moscona-lab |access-date=2022-07-07 |website=Department of Pediatrics |language=en}} Her research program focuses on paramyxoviruses, a family of negative-sense RNA viruses that cause severe illness in humans,{{Cite journal |last1=Moscona |first1=Anne |last2=Peluso |date=June 1991 |title=Fusion Properties of Cells Persistently Infected with Human Parainfluenza Virus Type 3: Participation of HemagglutininNeuraminidase in Membrane Fusion |journal=Journal of Virology |volume=65 |issue=6 |pages=2773–2777|doi=10.1128/JVI.65.6.2773-2777.1991 |pmid=1851852 |pmc=240891 }}{{Cite journal |last1=Porotto |first1=M. |last2=Ferren |first2=M. |last3=Chen |first3=Y.-W. |last4=Siu |first4=Y. |last5=Makhsous |first5=N. |last6=Rima |first6=B. |last7=Briese |first7=T. |last8=Greninger |first8=A. L. |author8-link=Alexander L. Greninger|last9=Snoeck |first9=H.-W. |last10=Moscona |first10=A. |date=2019-06-25 |editor-last=Schultz-Cherry |editor-first=Stacey |others=Carolyn Coyne, John Williams |title=Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids |journal=mBio |language=en |volume=10 |issue=3 |pages=e00723–19 |doi=10.1128/mBio.00723-19 |issn=2161-2129 |pmc=6509192 |pmid=31064833}}{{Cite journal |last1=Greninger |first1=Alexander L. |last2=Rybkina |first2=Ksenia |last3=Lin |first3=Michelle J. |last4=Drew-Bear |first4=Jennifer |last5=Marcink |first5=Tara C. |last6=Shean |first6=Ryan C. |last7=Makhsous |first7=Negar |last8=Boeckh |first8=Michael |last9=Harder |first9=Olivia |last10=Bovier |first10=Francesca |last11=Burstein |first11=Shana R. |date=2021-12-01 |title=Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence |url=https://www.jci.org/articles/view/150506 |journal=The Journal of Clinical Investigation |language=en |volume=131 |issue=23 |doi=10.1172/JCI150506 |pmid=34609969 |pmc=8631596 |issn=0021-9738}} and her group has developed new techniques to block viral infection through fusion inhibition,{{Cite journal |last=Moscona |first=Anne |date=2005-07-01 |title=Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease |url=https://www.jci.org/articles/view/25669 |journal=The Journal of Clinical Investigation |language=en |volume=115 |issue=7 |pages=1688–1698 |doi=10.1172/JCI25669 |issn=0021-9738 |pmid=16007245|pmc=1159152 }}{{Cite journal |last1=Porotto |first1=Matteo |last2=Rockx |first2=Barry |last3=Yokoyama |first3=Christine C. |last4=Talekar |first4=Aparna |last5=DeVito |first5=Ilaria |last6=Palermo |first6=Laura M. |last7=Liu |first7=Jie |last8=Cortese |first8=Riccardo |last9=Lu |first9=Min |last10=Feldmann |first10=Heinz |last11=Pessi |first11=Antonello |date=2010-10-28 |title=Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry |journal=PLOS Pathogens |language=en |volume=6 |issue=10 |pages=e1001168 |doi=10.1371/journal.ppat.1001168 |issn=1553-7374 |pmc=2965769 |pmid=21060819 |doi-access=free }} most recently developing fusion inhibitory peptides for SARS-CoV-2.{{Cite journal |last1=Outlaw |first1=Victor K. |last2=Bovier |first2=Francesca T. |last3=Mears |first3=Megan C. |last4=Cajimat |first4=Maria N. |last5=Zhu |first5=Yun |last6=Lin |first6=Michelle J. |last7=Addetia |first7=Amin |last8=Lieberman |first8=Nicole A. P. |last9=Peddu |first9=Vikas |last10=Xie |first10=Xuping |last11=Shi |first11=Pei-Yong |date=2020-10-27 |editor-last=Schultz-Cherry |editor-first=Stacey |title=Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain |journal=mBio |language=en |volume=11 |issue=5 |pages=e01935–20 |doi=10.1128/mBio.01935-20 |issn=2161-2129 |pmc=7587434 |pmid=33082259}}{{Cite journal |last1=de Vries |first1=Rory D. |last2=Schmitz |first2=Katharina S. |last3=Bovier |first3=Francesca T. |last4=Predella |first4=Camilla |last5=Khao |first5=Jonathan |last6=Noack |first6=Danny |last7=Haagmans |first7=Bart L. |last8=Herfst |first8=Sander |last9=Stearns |first9=Kyle N. |last10=Drew-Bear |first10=Jennifer |last11=Biswas |first11=Sudipta |date=2021-03-26 |title=Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets |journal=Science |language=en |volume=371 |issue=6536 |pages=1379–1382 |doi=10.1126/science.abf4896 |issn=0036-8075 |pmc=8011693 |pmid=33597220|bibcode=2021Sci...371.1379D }} She is frequently consulted as a medical expert during viral outbreaks, including epidemic and pandemic influenza.{{Cite web |title=CNN.com - Expert: Window exists to prepare for pandemic - Nov 1, 2005 |url=https://www.cnn.com/2005/HEALTH/conditions/11/01/flu.q.a/index.html |access-date=2022-07-07 |website=www.cnn.com}}{{Cite news |last=McNeil |first=Donald G. Jr. |date=2009-05-21 |title=As Flu Suspicions Spread, Value of Test Is Weighed |url=https://www.nytimes.com/2009/05/21/health/21diagnosis.html |access-date=2022-07-07 |work=The New York Times |language=en-US |issn=0362-4331}}{{Cite journal |last=Moscona |first=Anne |date=2005-12-22 |title=Oseltamivir Resistance — Disabling Our Influenza Defenses |journal=New England Journal of Medicine |volume=353 |issue=25 |pages=2633–2636 |doi=10.1056/NEJMp058291 |issn=0028-4793 |pmid=16371626 |doi-access=free}} Her research has been featured in outlets including Nature, Science, the New England Journal of Medicine, the New York Times, CNN, NBC, ABC and The Hill.{{Cite journal |last1=Folkman |first1=Judah |last2=Moscona |first2=Anne |date=June 1978 |title=Role of cell shape in growth control |url=https://www.nature.com/articles/273345a0 |journal=Nature |language=en |volume=273 |issue=5661 |pages=345–349 |doi=10.1038/273345a0 |pmid=661946 |bibcode=1978Natur.273..345F |s2cid=4161255 |issn=1476-4687|url-access=subscription }}{{Cite journal |last=Moscona |first=Anne |date=2005-09-29 |title=Neuraminidase Inhibitors for Influenza |journal=New England Journal of Medicine |volume=353 |issue=13 |pages=1363–1373 |doi=10.1056/NEJMra050740 |issn=0028-4793 |pmid=16192481|doi-access=free }}{{Cite web |title=New treatment may protect babies against dangerous respiratory virus, study shows |url=https://www.nbcnews.com/health/kids-health/rsv-treatment-may-prevent-respiratory-virus-babies-rcna18279 |access-date=2022-07-07 |website=NBC News |date=3 March 2022 |language=en}}
COVID-19
On November 5, 2020, the New York Times reported that Moscona's research group had collaboratively developed “A nasal spray that blocks the absorption of the SARS-CoV-2 virus...” and that it had “...completely protected ferrets it was tested on, according to a small study...”{{Cite news |last=McNeil |first=Donald G. Jr. |date=2020-11-05 |title=Nasal Spray Prevents Covid Infection in Ferrets, Study Finds |language=en-US |work=The New York Times |url=https://www.nytimes.com/2020/11/05/health/coronavirus-ferrets-vaccine-spray.html |access-date=2022-07-08 |issn=0362-4331}} According to the article, the therapeutics are patent pending and awaiting market production.
Awards
- 1985: Charles H. Revson Foundation Fellowship for Biomedical Research.{{Cite web |title=The Charles H. Revson Senior Fellowship in Biomedical Science {{!}} The Charles H. Revson Foundation |url=https://revsonfoundation.org/fellowships/biomedical-fellowships/ |access-date=2022-07-07 |language=en-US}}
- 1992: Elected to the Society for Pediatric Research.
- 1992: Pediatric Infectious Disease Society Young Investigator Award.{{Cite web |last=Foundation |first=PIDS |title=Young Investigator Award – PIDS Foundation |url=https://pidsfoundation.org/young-investigator-award/ |access-date=2022-07-07 |website=pidsfoundation.org |language=en-US}}
- 1992: Hirschl/Monique Weill-Caulier Career Scientist Award.{{Cite news |date=1982-01-31 |title=AWARDS FOR MEDICAL RESEARCH |language=en-US |work=The New York Times |url=https://www.nytimes.com/1982/01/31/nyregion/awards-for-medical-research.html |access-date=2022-07-07 |issn=0362-4331}}
- 2002: Elected to American Society for Clinical Investigation.{{Cite web |title=The American Society for Clinical Investigation |url=https://the-asci.org/contact.shtml |access-date=2022-07-07 |language=en-US}}
- 2006: Burroughs Welcome Fund Pathogenesis of Infectious Disease Award Advisory Committee.{{Cite web |title=Investigators in the Pathogenesis of Infectious Disease |url=https://www.bwfund.org/funding-opportunities/infectious-diseases/investigators-in-the-pathogenesis-of-infectious-disease/ |access-date=2022-07-07 |website=Burroughs Wellcome Fund |language=en-US}}
- 2009: Elected to Fellowship in the American Academy of Microbiology.{{Cite web |title=American Academy of Microbiology |url=https://asm.org/Academy/Academy |access-date=2022-07-07 |website=ASM.org |language=en}}
- 2019: Elected Councilor for Medical Virology, American Society for Virology.{{Cite web |title=About ASV |url=https://asv.org/about-asv/ |access-date=2022-07-07 |website=American Society for Virology |language=en-US}}
- 2020: Harrington Discovery Institute Awardee (COVID program).{{Cite web |title=Anne Moscona, MD {{!}} Scholars {{!}} Harrington Discovery Institute at University Hospitals |url=https://www.harringtondiscovery.org/scholars/anne-moscona |access-date=2022-07-07 |website=www.harringtondiscovery.org |language=en}}
- 2022: Elected President of the American Society for Virology.{{Cite web |title=Public Affairs |url=https://asv.org/public-affairs/ |access-date=2022-07-07 |website=American Society for Virology |language=en-US}}{{Cite web |date=2022-06-14 |title=Columbia Virologist-Pediatrician to Lead Nation's Leading Virus Research Organization |url=https://www.cuimc.columbia.edu/news/columbia-virologist-pediatrician-lead-nations-leading-virus-research-organization |access-date=2022-07-07 |website=Columbia University Irving Medical Center |language=en}}
References
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Category:Year of birth missing (living people)
Category:Physicians from Chicago
Category:American pediatricians
Category:Columbia University Vagelos College of Physicians and Surgeons alumni
Category:Harvard University alumni
Category:Scientists from Chicago
Category:Columbia University faculty
Category:American people of Israeli descent
Category:Weill Medical College of Cornell University faculty
Category:21st-century American women physicians
Category:21st-century American physicians