Annexin A3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.{{cite journal |vauthors=Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM | title = Chromosomal localization of the human annexin III (ANX3) gene | journal = Genomics | volume = 10 | issue = 2 | pages = 441–8 |date=Aug 1991 | pmid = 1830024 | doi =10.1016/0888-7543(91)90330-H }}{{cite web | title = Entrez Gene: ANXA3 annexin A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=306}}
It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.{{cite journal |vauthors=Zhang Y, Zhang YL, Feng C |title=Comparative proteomic analysis of human placenta derived from assisted reproductive technology |journal=Proteomics |volume= 8|issue= 20|pages= 4344–56|date=September 2008 |pmid=18792929 |doi=10.1002/pmic.200800294 |s2cid=206362532 |display-authors=etal}}
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
References
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External links
- {{UCSC gene info|ANXA3}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Ernst JD, Hoye E, Blackwood RA, Jaye D |title=Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. |journal=J. Clin. Invest. |volume=85 |issue= 4 |pages= 1065–71 |year= 1990 |pmid= 2138632 |doi=10.1172/JCI114537 | pmc=296536 }}
- {{cite journal |vauthors=Ross TS, Tait JF, Majerus PW |title=Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. |journal=Science |volume=248 |issue= 4955 |pages= 605–7 |year= 1990 |pmid= 2159184 |doi=10.1126/science.2159184 |bibcode=1990Sci...248..605R }}
- {{cite journal |vauthors=Pepinsky RB, Tizard R, Mattaliano RJ |title=Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. |journal=J. Biol. Chem. |volume=263 |issue= 22 |pages= 10799–811 |year= 1988 |doi=10.1016/S0021-9258(18)38041-4 |pmid= 2968983 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Tait JF, Sakata M, McMullen BA |title=Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. |journal=Biochemistry |volume=27 |issue= 17 |pages= 6268–76 |year= 1989 |pmid= 2975506 |doi=10.1021/bi00417a011 |display-authors=etal}}
- {{cite journal |vauthors=Tait JF, Smith C, Xu L, Cookson BT |title=Structure and polymorphisms of the human annexin III (ANX3) gene. |journal=Genomics |volume=18 |issue= 1 |pages= 79–86 |year= 1994 |pmid= 8276419 |doi= 10.1006/geno.1993.1428 }}
- {{cite journal |vauthors=Sekar MC, Sambandam V, Grizzle WE, McDonald JM |title=Dissociation of cyclic inositol phosphohydrolase activity from annexin III. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8295–9 |year= 1996 |pmid= 8626524 |doi=10.1074/jbc.271.14.8295 |doi-access=free }}
- {{cite journal |vauthors=Favier-Perron B, Lewit-Bentley A, Russo-Marie F |title=The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. |journal=Biochemistry |volume=35 |issue= 6 |pages= 1740–4 |year= 1996 |pmid= 8639653 |doi= 10.1021/bi952092o }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Cargill M, Altshuler D, Ireland J |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231–8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 |s2cid=195213008 |display-authors=etal}}
- {{cite journal |vauthors=Bödeker H, Keim V, Fiedler F |title=PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha. |journal=Mol. Cell Biol. Res. Commun. |volume=2 |issue= 3 |pages= 150–4 |year= 2000 |pmid= 10662590 |doi= 10.1006/mcbr.1999.0166 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Bruneel A, Labas V, Mailloux A |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 |s2cid=26007149 |display-authors=etal}}
- {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal|hdl=11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access=free }}
- {{cite journal |vauthors=Park JE, Lee DH, Lee JA |title=Annexin A3 is a potential angiogenic mediator. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1283–7 |year= 2005 |pmid= 16236264 |doi= 10.1016/j.bbrc.2005.10.004 |display-authors=etal}}
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