Anthranilate-based insect repellents

Anthranilate-based insect repellents include methyl anthranilate, N,N-dimethylanthranilic acid (DMA), ethyl anthranilate (EA), and butyl anthranilate (BA). Chemically, they are esters of anthranilic acid. While the United States Food and Drug Administration (FDA) has approved some of these compounds for use as food additives,{{citation needed|date=January 2015}} cinnamyl anthranilate is banned by the FDA.{{cite web | title=Food Additive Status List | website=US Food and Drug Administration | date=2020-10-05 | url=http://www.fda.gov/food/food-additives-petitions/food-additive-status-list | access-date=2021-07-26}} The compounds repel both fruit flies and mosquitos, and target the same neurons that respond to DEET. The receptors are located on part of the antennae known as the sacculus.{{cite web|url=http://www.gizmag.com/natural-deet-alternatives-mosquitoes/29280/ |title=Scientists find key to more effective DEET alternatives |publisher=Gizmag.com |date= 4 October 2013|accessdate=2013-10-04}}

DMA and EA repel mosquitos from feeding on humans, while EA and BA repel them from depositing eggs in water.{{cite journal|title=Different Repellents for Aedes aegypti against Blood-Feeding and Oviposition | author=Ali Afify | author2=Bérénice Horlacher | author3=Johannes Roller | author4=C. Giovanni Galizia|journal=PLOS ONE|volume=9 |issue=7 |pages=e103765 | date= 2014-07-31 |doi=10.1371/journal.pone.0103765 |pmid=25079819 |bibcode=2014PLoSO...9j3765A | pmc=4117642| doi-access=free }}{{Cite journal | doi = 10.1371/journal.pone.0103765| title = Different Repellents for Aedes aegypti against Blood-Feeding and Oviposition| journal = PLOS ONE| volume = 9| issue = 7| pages = e103765| year = 2014| last1 = Afify | first1 = A. | last2 = Horlacher | first2 = B. R. N. | last3 = Roller | first3 = J. | last4 = Galizia | first4 = C. G. | pmid=25079819 | pmc=4117642| bibcode = 2014PLoSO...9j3765A| doi-access = free}}