Apolipoprotein C-IV

APOC4 is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. APOC4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.

{{reflist}}

• {{UCSC gene info|APOC4}}

{{refbegin | 2}}

• {{cite journal |vauthors=Kim E, Li K, Lieu C |title=Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. |journal=J. Hepatol. |volume=49 |issue= 5 |pages= 787–98 |year= 2008 |pmid= 18809223 |doi= 10.1016/j.jhep.2008.06.029 |pmc=2644636 |display-authors=etal}}
• {{cite journal |vauthors=Burkhardt R, Kenny EE, Lowe JK |title=Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13 |journal=Arterioscler. Thromb. Vasc. Biol. |volume=28 |issue= 11 |pages= 2078–84 |year= 2008 |pmid= 18802019 |doi= 10.1161/ATVBAHA.108.172288 |pmc=2764366 |display-authors=etal}}
• {{cite journal |vauthors=Willer CJ, Sanna S, Jackson AU |title=Newly identified loci that influence lipid concentrations and risk of coronary artery disease |journal=Nat. Genet. |volume=40 |issue= 2 |pages= 161–9 |year= 2008 |pmid= 18193043 |doi= 10.1038/ng.76 |display-authors=etal|pmc=5206900 }}
• {{cite journal |vauthors=Mak PA, Laffitte BA, Desrumaux C |title=Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31900–8 |year= 2002 |pmid= 12032151 |doi= 10.1074/jbc.M202993200 |display-authors=etal|doi-access=free }}
• {{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2005|pmid= 16335952 |doi= 10.1021/pr0502065 |pmc=1850943|display-authors=etal}}
• {{cite journal |vauthors=Kathiresan S, Willer CJ, Peloso GM |title=Common variants at 30 loci contribute to polygenic dyslipidemia |journal=Nat. Genet. |volume=41 |issue= 1 |pages= 56–65 |year= 2009 |pmid= 19060906 |doi= 10.1038/ng.291 |pmc=2881676|display-authors=etal}}
• {{cite journal |vauthors=Mosbruger TL, Duggal P, Goedert JJ |title=Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus |journal=J. Infect. Dis. |volume=201 |issue= 9 |pages= 1371–80 |year= 2010 |pmid= 20331378 |doi= 10.1086/651606 |pmc=2853721 |display-authors=etal}}
• {{cite journal |vauthors=Ken-Dror G, Talmud PJ, Humphries SE, Drenos F |title=APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men |journal=Molecular Medicine |volume= 16|issue= 9–10|pages= 389–99 |year= 2010 |pmid= 20498921 |doi= 10.2119/molmed.2010.00044 |pmc=2935949 }}
• {{cite journal |vauthors=Marques-Vidal P, Bochud M, Paccaud F |title=No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels |journal=Atherosclerosis |volume=211 |issue= 2 |pages= 551–7 |year= 2010 |pmid= 20430392 |doi= 10.1016/j.atherosclerosis.2010.04.001 |display-authors=etal}}
• {{cite journal |vauthors=Talmud PJ, Drenos F, Shah S |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628–42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 |pmc=2775832|display-authors=etal}}
• {{cite journal |vauthors=Drenos F, Talmud PJ, Casas JP |title=Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk |journal=Hum. Mol. Genet. |volume=18 |issue= 12 |pages= 2305–16 |year= 2009 |pmid= 19336475 |doi= 10.1093/hmg/ddp159 |pmc=2685759|display-authors=etal}}
• {{cite journal |vauthors=Kathiresan S, Melander O, Guiducci C |title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans |journal=Nat. Genet. |volume=40 |issue= 2 |pages= 189–97 |year= 2008 |pmid= 18193044 |doi= 10.1038/ng.75 |pmc=2682493|display-authors=etal}}
• {{cite journal |vauthors=Mancone C, Amicone L, Fimia GM |title=Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF |journal=Proteomics |volume=7 |issue= 1 |pages= 143–54 |year= 2007 |pmid= 17154273 |doi= 10.1002/pmic.200600339 |s2cid=41502305 |display-authors=etal}}
• {{cite journal |vauthors=Lowe JK, Maller JB, Pe'er I |title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae |journal=PLOS Genet. |volume=5 |issue= 2 |pages= e1000365 |year= 2009 |pmid= 19197348 |doi= 10.1371/journal.pgen.1000365 |editor1-last=Gibson |editor1-first=Greg |pmc=2628735 |display-authors=etal |doi-access=free }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
• {{cite journal |vauthors=Kamboh MI, Aston CE, Hamman RF |title=DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile |journal=Atherosclerosis |volume=152 |issue= 1 |pages= 193–201 |year= 2000 |pmid= 10996355 |doi= 10.1016/S0021-9150(99)00459-1}}
• {{cite journal |vauthors=Klos KL, Sing CF, Boerwinkle E |title=Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 8 |pages= 1828–36 |year= 2006 |pmid= 16763159 |doi= 10.1161/01.ATV.0000231523.19199.45 |display-authors=etal|doi-access=free }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal |vauthors=Kotite L, Zhang LH, Yu Z |title=Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins |journal=J. Lipid Res. |volume=44 |issue= 7 |pages= 1387–94 |year= 2003 |pmid= 12700345 |doi= 10.1194/jlr.M300087-JLR200 |display-authors=etal|doi-access=free }}

{{refend}}

{{NLM content}}

{{Lipoproteins}}

Category:Apolipoproteins

{{gene-19-stub}}