Arginine alpha-ketoglutarate

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Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement.{{cite journal|last=Wax|first=B|author2=A Kavazis|author3=H Webb|author4=S Brown|title=Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men|journal=Journal of the International Society of Sports Nutrition|date=2012|volume=9|issue=17|page=17|doi=10.1186/1550-2783-9-17|pmc=3428651|pmid=22510253|doi-access=free}}

Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement.{{cite journal|last=Willoughby|first=DS|author2=Boucher T|author3=Reid J|author4=Skelton G|author5=Clark M|title=Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise|journal=International Journal of Sport Nutrition and Exercise Metabolism|date=Aug 2011|volume=21|issue=4|pages=291–9|pmid=21813912|doi=10.1123/ijsnem.21.4.291}}{{cite journal|last=Greer|first=BK|author2=Jones BT|title=Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training|journal=Journal of Strength and Conditioning Research|date=Jul 2011|volume=25|issue=7|pages=1789–94|pmid=21399536|doi=10.1519/JSC.0b013e3181e07569|s2cid=11182086 |doi-access=free}}