AsponA antisense RNA

{{Infobox rfam

| Name = AsponA antisense RNA

| image = RF02812.svg

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| caption = Predicted secondary structure and sequence conservation of AsponA antisense RNA

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| Rfam = RF02812

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| Tax_domain = Bacteria

| GO = {{GO|0046677}}

| SO = {{SO|0000077}},{{SO|0000370}}

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}}AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ponA. It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in Pseudomanas aeruginosa. AsponA expression was up or down regulated under different antibiotic stress. Owing to its location it may be able to prevent the transcription or translation of the opposite gene.{{cite journal | vauthors = Gómez-Lozano M, Marvig RL, Tulstrup MV, Molin S | title = Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa | journal = BMC Genomics | volume = 15 | pages = 783 | date = September 2014 | issue = 1 | pmid = 25213728 | pmc = 4180829 | doi = 10.1186/1471-2164-15-783 | doi-access = free }} Study by Wurtzel et al. and Ferrara et al. also detected its expression.{{cite journal | vauthors = Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S | title = The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature | journal = PLOS Pathogens | volume = 8 | issue = 9 | pages = e1002945 | date = September 2012 | pmid = 23028334 | pmc = 3460626 | doi = 10.1371/journal.ppat.1002945 | doi-access = free }}{{cite journal | vauthors = Ferrara S, Brugnoli M, De Bonis A, Righetti F, Delvillani F, Dehò G, Horner D, Briani F, Bertoni G | title = Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs | journal = PLOS ONE | volume = 7 | issue = 5 | pages = e36553 | date = 2012 | pmid = 22590564 | pmc = 3349714 | doi = 10.1371/journal.pone.0036553 | bibcode = 2012PLoSO...736553F | doi-access = free }}