Aspoxicillin

{{Short description|Chemical compound}}

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| image = Aspoxicillin.svg

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| tradename = Doyle

| synonyms = TA-058

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| CAS_number = 63358-49-6

| PubChem = 71961

| UNII = 0745KNO26J

| DrugBank = DB13816

| IUPAC_name = (2S,5R,6R)-6-[[(2R)-2-[[(2R)-2-Amino-4-(methylamino)-4-oxobutanoyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

| C = 21 | H = 27 | N = 5 | O = 7 | S = 1

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Aspoxicillin (trade name Doyle{{cite web | url = https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=12293 | title = Aspoxicillin | work = IUPHAR/BPS Guide to Pharmacology }}) is an antibiotic drug of the beta-lactam class.{{cite journal | vauthors = Matsumoto K | title = [Review: New antimicrobial agent series XXII: Aspoxicillin] | journal = The Japanese Journal of Antibiotics | volume = 40 | issue = 7 | pages = 1221–1242 | date = July 1987 | pmid = 3316732 }} It is an injectable form of penicillin that is highly active against Gram-positive and Gram-negative bacteria, including Bacillus fragilis,{{cite web | url = https://drugs.ncats.io/substance/0745KNO26J | title = Aspoxicillin | work = Inxight Drugs | publisher = National Center for Advancing Translational Sciences }} which is resistant to other beta-lactam antibiotics.{{cite journal | vauthors = Edwards R | title = Resistance to beta-lactam antibiotics in Bacteroides spp | journal = Journal of Medical Microbiology | volume = 46 | issue = 12 | pages = 979–986 | date = December 1997 | pmid = 9402919 | doi = 10.1099/00222615-46-12-979 }} It is approved for use in Japan.