Axial osteosclerosis
{{Short description|Bone disorder}}
Axial osteosclerosis, also known as osteomesopyknosis, is a bone disorder that causes osteosclerosis on the axial spine, pelvis and proximal part of the long bones. It is an autosomal-dominant disease. As of 2024, the exact causes were unknown.{{Cite web |title=Osteomesopyknosis – About the Disease – Genetic and Rare Diseases Information Center |url=https://rarediseases.info.nih.gov/diseases/391/osteomesopyknosis |access-date=2024-03-09 |website=rarediseases.info.nih.gov |language=en}}
Population estimation
Fewer than 1000 people have this bone disorder in the United States.
Symptoms
This bone disorder can begin to appear in the first years of life, as well as in adulthood. It may present with thoracic pain,{{Cite journal |last=Maroteaux |first=P. |date=March 1980 |title=[Osteomesopycnosis. A new autosomal dominant osteosclerosing bone disease (author's transl)] |url=https://pubmed.ncbi.nlm.nih.gov/7469692/ |journal=Archives Françaises de Pédiatrie |volume=37 |issue=3 |pages=153–157 |issn=0003-9764 |pmid=7469692}} kyphosis, scoliosis, vertebral body sclerosis, increased bone density, as well as abnormalities in the cortical bone and vertebrae.