Azficel-T
{{Short description|Medication for nasolabial fold wrinkles}}
{{Context|date=March 2021}}
{{Use dmy dates|date=April 2020}}
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| tradename = Laviv
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| routes_of_administration = Intradermal
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| DrugBank = DB11051
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| UNII = 022461SR75
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Azficel-T, sold under the brand name Laviv, is a cell therapy product for the improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults.{{cite web | title=Laviv (Azficel-T) | website=U.S. Food and Drug Administration (FDA) | date=22 July 2017 | url=https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/laviv-azficel-t | access-date=1 April 2020 | archive-date=16 December 2019 | archive-url=https://web.archive.org/web/20191216220945/https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/laviv-azficel-t | url-status=dead }}{{cite web | title=Autologous Fibroblasts | website=U.S. Food and Drug Administration (FDA) | url=https://www.fda.gov/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/ucm260485.htm | date=29 June 2017 | archive-date=22 July 2017 | archive-url=https://wayback.archive-it.org/7993/20170722071310/https://www.fda.gov/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/ucm260485.htm | url-status=unfit | access-date=1 April 2020}}{{cite web | url=https://www.fda.gov/media/80838/download | format=PDF | title=Laviv (azficel-T) Suspension for Intradermal Injection | website=Food and Drug Administration | access-date=2 April 2020 | archive-date=14 December 2019 | archive-url=https://web.archive.org/web/20191214043112/https://www.fda.gov/media/80838/download | url-status=dead }} It consists of fibroblasts harvested from the patient's own skin.
It was approved for medical use in the United States in June 2011.
References
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Further reading
- {{cite journal |vauthors=Smith SR, Munavalli G, Weiss R, Maslowski JM, Hennegan KP, Novak JM |display-authors=3 |title=A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles |journal=Dermatol Surg |volume=38 |issue=7 Pt 2 |pages=1234–43 |date=July 2012 |pmid=22409385 |doi=10.1111/j.1524-4725.2012.02349.x |s2cid=24901992 }}
External links
- {{cite web | title=Laviv (azficel-T) | website=Medscape | date=28 September 2019 | url=https://reference.medscape.com/drug/laViv-azficel-t-999666 }}
- {{ClinicalTrialsGov|NCT02120781|Controlled Study to Evaluate the Safety and Efficacy of Azficel-T for the Treatment of Vocal Fold Scarring and Age-Related Dysphonia}}
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