BAAT
{{Short description|Mammalian protein found in Homo sapiens}}
{{Infobox_gene}}
Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.{{cite web | title = Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=570}}
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.
References
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External links
- {{UCSC gene info|BAAT}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Johnson MR, Barnes S, Kwakye JB, Diasio RB |title=Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10227–33 |year= 1991 |doi=10.1016/S0021-9258(18)99213-6 |pmid= 2037576 |doi-access=free }}
- {{cite journal | vauthors=Falany CN, Johnson MR, Barnes S, Diasio RB |title=Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19375–9 |year= 1994 |doi=10.1016/S0021-9258(17)32178-6 |pmid= 8034703 |doi-access=free }}
- {{cite journal | vauthors=Lench NJ, Telford EA, Andersen SE |title=An EST and STS-based YAC contig map of human chromosome 9q22.3. |journal=Genomics |volume=38 |issue= 2 |pages= 199–205 |year= 1997 |pmid= 8954802 |doi= 10.1006/geno.1996.0616 |display-authors=etal}}
- {{cite journal | vauthors=Solaas K, Ulvestad A, Söreide O, Kase BF |title=Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. |journal=J. Lipid Res. |volume=41 |issue= 7 |pages= 1154–62 |year= 2000 |doi=10.1016/S0022-2275(20)32022-8 |pmid= 10884298 |doi-access=free }}
- {{cite journal | vauthors=Sfakianos MK, Wilson L, Sakalian M |title=Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47270–5 |year= 2003 |pmid= 12239217 |doi= 10.1074/jbc.M207463200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Carlton VE, Harris BZ, Puffenberger EG |title=Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 91–6 |year= 2003 |pmid= 12704386 |doi= 10.1038/ng1147 |s2cid=21900697 |display-authors=etal}}
- {{cite journal | vauthors=Wang H, Tamba M, Kimata M |title=Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 3 |pages= 611–8 |year= 2003 |pmid= 12763038 |doi=10.1016/S0006-291X(03)00808-8 |display-authors=etal}}
- {{cite journal | vauthors=O'Byrne J, Hunt MC, Rai DK |title=The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34237–44 |year= 2003 |pmid= 12810727 |doi= 10.1074/jbc.M300987200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |bibcode=2004Natur.429..369H |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
- {{cite journal | vauthors=Pellicoro A, van den Heuvel FA, Geuken M |title=Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. |journal=Hepatology |volume=45 |issue= 2 |pages= 340–8 |year= 2007 |pmid= 17256745 |doi= 10.1002/hep.21528 |s2cid=6163420 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Tougou K, Fukuda T, Ito T |title=Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. |journal=Drug Metab. Pharmacokinet. |volume=22 |issue= 2 |pages= 125–8 |year= 2007 |pmid= 17495420 |doi=10.2133/dmpk.22.125 |display-authors=etal}}
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