BACE1-AS

{{Short description|Non-coding RNA in the species Homo sapiens}}

{{Infobox_gene}}

BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.{{cite journal |vauthors=Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C |title=Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase |journal=Nat Med |volume=14 |issue=7|pages=723–730 |year=2008 |pmid=18587408 |doi=10.1038/nm1784 |pmc=2826895}} BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.

Knocking down BACE1-AS reduces amyloid production and plaque deposition.{{cite journal |vauthors=Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA |title=Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis |journal=Int. J. Alzheimer's Dis.|year=2011 |pmid=21785702 |doi=10.4061/2011/929042 |volume=2011 |pmc=3139208 |pages=929042 |doi-access=free }}