BAFF receptor

B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. In B cell maturation, due to regulation by BAFF-R, only a limited amount of B-cell will survive.{{cite journal | vauthors = Brink R | title = Regulation of B cell self-tolerance by BAFF | journal = Seminars in Immunology | volume = 18 | issue = 5 | pages = 276–83 | date = October 2006 | pmid = 16916609 | doi = 10.1016/j.smim.2006.04.003 }}

Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells, which are cells that show immune response to normal body cells. Autoreactive B cells are less sensitive toward BAFF and are usually outcompeted by the normal B cells in the maturation process regulated by low BAFF-R expression. An elevated level of BAFF-R can therefore overcome this decreased response and result in accumulation of autoreactive B cells.

BAFF and BAFF-R pair can also down-regulate the cell apoptosis process.{{cite journal | vauthors = Rauch M, Tussiwand R, Bosco N, Rolink AG | title = Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells | journal = PLOS ONE | volume = 4 | issue = 5 | pages = e5456 | date = 2009-05-06 | pmid = 19421318 | pmc = 2673681 | doi = 10.1371/journal.pone.0005456 | bibcode = 2009PLoSO...4.5456R | doi-access = free }}

• B-cell activating factor
• B-cell maturation antigen

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• {{UCSC gene info|TNFRSF13C}}

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• {{cite journal | vauthors = Laâbi Y, Egle A, Strasser A | title = TNF cytokine family: more BAFF-ling complexities | journal = Current Biology | volume = 11 | issue = 24 | pages = R1013-6 | date = December 2001 | pmid = 11747837 | doi = 10.1016/S0960-9822(01)00613-3 | s2cid = 17001236 | doi-access = free | bibcode = 2001CBio...11R1013L }}
• {{cite book | vauthors = Defrance T, Casamayor-Pallejà M, Krammer PH | title = The life and death of a B cell | journal = Advances in Cancer Research | volume = 86 | pages = 195–225 | year = 2003 | pmid = 12374279 | doi = 10.1016/S0065-230X(02)86006-7 | isbn = 9780120066865 }}
• {{cite journal | vauthors = Ambrose CM | title = BAFF-R | journal = Journal of Biological Regulators and Homeostatic Agents | volume = 16 | issue = 3 | pages = 211–3 | year = 2003 | pmid = 12456020 }}
• {{cite journal | vauthors = Bossen C, Schneider P | title = BAFF, APRIL and their receptors: structure, function and signaling | journal = Seminars in Immunology | volume = 18 | issue = 5 | pages = 263–75 | date = October 2006 | pmid = 16914324 | doi = 10.1016/j.smim.2006.04.006 | url = https://serval.unil.ch/resource/serval:BIB_89872BC6E950.P001/REF.pdf }}
• {{cite journal | vauthors = Treml LS, Crowley JE, Cancro MP | title = BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells | journal = Seminars in Immunology | volume = 18 | issue = 5 | pages = 297–304 | date = October 2006 | pmid = 16919470 | doi = 10.1016/j.smim.2006.07.001 }}
• {{cite journal | vauthors = Kalled SL | title = Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production | journal = Seminars in Immunology | volume = 18 | issue = 5 | pages = 290–6 | date = October 2006 | pmid = 16931038 | doi = 10.1016/j.smim.2006.06.002 }}
• {{cite journal | vauthors = Mackay F, Leung H | title = The role of the BAFF/APRIL system on T cell function | journal = Seminars in Immunology | volume = 18 | issue = 5 | pages = 284–9 | date = October 2006 | pmid = 16931039 | doi = 10.1016/j.smim.2006.04.005 }}
• {{cite journal | vauthors = Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J | title = BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth | journal = The Journal of Experimental Medicine | volume = 189 | issue = 11 | pages = 1747–56 | date = June 1999 | pmid = 10359578 | pmc = 2193079 | doi = 10.1084/jem.189.11.1747 }}
• {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
• {{cite journal | vauthors = Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, Cancro M, Grewal IS, Dixit VM | title = Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency | journal = Current Biology | volume = 11 | issue = 19 | pages = 1547–52 | date = October 2001 | pmid = 11591325 | doi = 10.1016/S0960-9822(01)00481-X | s2cid = 13925100 | doi-access = free | bibcode = 2001CBio...11.1547Y }}
• {{cite journal | vauthors = Rolink AG, Melchers F | title = BAFFled B cells survive and thrive: roles of BAFF in B-cell development | journal = Current Opinion in Immunology | volume = 14 | issue = 2 | pages = 266–75 | date = April 2002 | pmid = 11869903 | doi = 10.1016/S0952-7915(02)00332-1 }}
• {{cite journal | vauthors = Xu LG, Shu HB | title = TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production | journal = Journal of Immunology | volume = 169 | issue = 12 | pages = 6883–9 | date = December 2002 | pmid = 12471121 | doi = 10.4049/jimmunol.169.12.6883 | doi-access = free }}
• {{cite journal | vauthors = Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO | title = Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation | journal = Nature Structural Biology | volume = 10 | issue = 5 | pages = 342–8 | date = May 2003 | pmid = 12715002 | doi = 10.1038/nsb925 | s2cid = 11294267 | hdl = 10203/11495 | hdl-access = free }}
• {{cite journal | vauthors = Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G | title = Ligand-receptor binding revealed by the TNF family member TALL-1 | journal = Nature | volume = 423 | issue = 6935 | pages = 49–56 | date = May 2003 | pmid = 12721620 | doi = 10.1038/nature01543 | bibcode = 2003Natur.423...49L | s2cid = 4373708 | doi-access = free }}
• {{cite journal | vauthors = Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA | title = BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site | journal = Biochemistry | volume = 42 | issue = 20 | pages = 5977–83 | date = May 2003 | pmid = 12755599 | doi = 10.1021/bi034017g }}

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Category:Clusters of differentiation

Category:TNF receptor family

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