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BAG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.{{cite journal | vauthors = Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC | title = Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity | journal = Cell | volume = 80 | issue = 2 | pages = 279–84 |date=March 1995 | pmid = 7834747 | doi =10.1016/0092-8674(95)90410-7 | s2cid = 17824475 | doi-access = free }}

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.{{cite web | title = Entrez Gene: BAG1 BCL2-associated athanogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573}}

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.{{cite journal | vauthors = Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C | title = Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 | journal = EMBO J. | volume = 28 | issue = 7 | pages = 889–901 | year = 2009 | pmid = 19229298 | pmc = 2647772 | doi = 10.1038/emboj.2009.29}} *{{lay source |template=cite web |url = https://phys.org/news/2009-03-cells-differently.html|title=Old Cells Work Differently|date = March 1, 2009|website = Phys.org }}

Interactions

BAG1 has been shown to interact with:

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  • Androgen receptor,{{cite journal | date = October 2003 | vauthors = Shatkina L, Mink S, Rogatsch H, Klocker H, Langer G, Nestl A, Cato AC | title = The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor | journal = Mol. Cell. Biol. | volume = 23 | issue = 20 | pages = 7189–97 | pmid = 14517289 | pmc = 230325 | doi = 10.1128/mcb.23.20.7189-7197.2003}}{{cite journal | date = April 2001 | vauthors = Knee DA, Froesch BA, Nuber U, Takayama S, Reed JC | title = Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12718–24 | pmid = 11278763 | doi = 10.1074/jbc.M010841200| doi-access = free }}{{cite journal | date = May 1998 | vauthors = Froesch BA, Takayama S, Reed JC | title = BAG-1L protein enhances androgen receptor function | journal = J. Biol. Chem. | volume = 273 | issue = 19 | pages = 11660–6 | pmid = 9565586 | doi = 10.1074/jbc.273.19.11660| doi-access = free }}
  • C-Raf,{{cite journal | date = July 1996 | vauthors = Wang HG, Takayama S, Rapp UR, Reed JC | title = Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 14 | pages = 7063–8 | pmid = 8692945 | pmc = 38936 | doi = 10.1073/pnas.93.14.7063| bibcode = 1996PNAS...93.7063W | doi-access = free }}
  • Calcitriol receptor,{{cite journal | date = Dec 2000 | vauthors = Guzey M, Takayama S, Reed JC | title = BAG1L enhances trans-activation function of the vitamin D receptor | journal = J. Biol. Chem. | volume = 275 | issue = 52 | pages = 40749–56 | pmid = 10967105 | doi = 10.1074/jbc.M004977200| doi-access = free }}
  • Glucocorticoid receptor,{{cite journal | date = June 1998 | vauthors = Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato AC | title = RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis | journal = J. Biol. Chem. | volume = 273 | issue = 23 | pages = 14620–5 | pmid = 9603979 | doi = 10.1074/jbc.273.23.14620| doi-access = free }}{{cite journal | date = Dec 2000 | vauthors = Schneikert J, Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato AC | title = Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6508–16 | pmid = 11101523 | pmc = 305849 | doi = 10.1093/emboj/19.23.6508}}
  • HSPA8,{{cite journal | date = August 1997 | vauthors = Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC | title = BAG-1 modulates the chaperone activity of Hsp70/Hsc70 | journal = EMBO J. | volume = 16 | issue = 16 | pages = 4887–96 | pmid = 9305631 | pmc = 1170124 | doi = 10.1093/emboj/16.16.4887}}{{cite journal | date = January 1999 | vauthors = Takayama S, Xie Z, Reed JC | title = An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 781–6 | pmid = 9873016 | doi = 10.1074/jbc.274.2.781| doi-access = free }}
  • HBEGF,{{cite journal | date = August 2001 | vauthors = Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR | title = BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 30127–32 | pmid = 11340068 | doi = 10.1074/jbc.M010237200| doi-access = free }}
  • PPP1R15A,{{cite journal | date = May 2003 | vauthors = Hung WJ, Roberson RS, Taft J, Wu DY | title = Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions | journal = Mol. Cell. Biol. | volume = 23 | issue = 10 | pages = 3477–86 | pmid = 12724406 | pmc = 164759 | doi = 10.1128/mcb.23.10.3477-3486.2003}}
  • NR1B1,{{cite journal | date = July 1998 | vauthors = Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK | title = Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells | journal = J. Biol. Chem. | volume = 273 | issue = 27 | pages = 16985–92 | pmid = 9642262 | doi = 10.1074/jbc.273.27.16985| doi-access = free }} and
  • SIAH1.{{cite journal | date = May 1998 | vauthors = Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC | title = p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1 | journal = EMBO J. | volume = 17 | issue = 10 | pages = 2736–47 | pmid = 9582267 | pmc = 1170614 | doi = 10.1093/emboj/17.10.2736}}

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References

{{Reflist}}

External links

  • {{UCSC gene info|BAG1}}

Further reading

{{Refbegin | 2}}

  • {{cite journal | author=Tang SC |title=BAG-1, an anti-apoptotic tumour marker. |journal=IUBMB Life |volume=53 |issue= 2 |pages= 99–105 |year= 2003 |pmid= 12049201 |doi=10.1080/15216540211473 |s2cid=8704191 |doi-access=free }}
  • {{cite journal | vauthors=Clemo NK, Arhel NJ, Barnes JD |title=The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 676–8 |year= 2005 |pmid= 16042572 |doi= 10.1042/BST0330676 |display-authors=etal}}
  • {{cite journal | author=Gehring U |title=Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms. |journal=Cell Stress & Chaperones |volume=11 |issue= 4 |pages= 295–303 |year= 2007 |doi=10.1379/1466-1268(2006)11[295:aotcba]2.0.co;2 |pmid= 17278878 | pmc=1712677 }}
  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors=Zeiner M, Gehring U |title=A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11465–9 |year= 1996 |pmid= 8524784 |doi=10.1073/pnas.92.25.11465 | pmc=40422 |doi-access=free }}
  • {{cite journal | vauthors=Wang HG, Takayama S, Rapp UR, Reed JC |title=Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7063–8 |year= 1996 |pmid= 8692945 |doi=10.1073/pnas.93.14.7063 | pmc=38936 |bibcode=1996PNAS...93.7063W |doi-access=free }}
  • {{cite journal | vauthors=Takayama S, Kochel K, Irie S |title=Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. |journal=Genomics |volume=35 |issue= 3 |pages= 494–8 |year= 1996 |pmid= 8812483 |doi= 10.1006/geno.1996.0389 |display-authors=etal|doi-access=free }}
  • {{cite journal |author1-link=Alberto Bardelli | vauthors=Bardelli A, Longati P, Albero D |title=HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. |journal=EMBO J. |volume=15 |issue= 22 |pages= 6205–12 |year= 1997 |pmid= 8947043 |doi= 10.1002/j.1460-2075.1996.tb01009.x| pmc=452442 |display-authors=etal}}
  • {{cite journal | vauthors=Takayama S, Bimston DN, Matsuzawa S |title=BAG-1 modulates the chaperone activity of Hsp70/Hsc70. |journal=EMBO J. |volume=16 |issue= 16 |pages= 4887–96 |year= 1997 |pmid= 9305631 |doi= 10.1093/emboj/16.16.4887 | pmc=1170124 |display-authors=etal}}
  • {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal | vauthors=Packham G, Brimmell M, Cleveland JL |title=Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. | series=328 |journal=Biochem. J. |volume=( Pt 3) |issue= 3|pages= 807–13 |year= 1998 |pmid= 9396724 |doi= 10.1042/bj3280807| pmc=1218990 }}
  • {{cite journal | vauthors=Matsuzawa S, Takayama S, Froesch BA |title=p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. |journal=EMBO J. |volume=17 |issue= 10 |pages= 2736–47 |year= 1998 |pmid= 9582267 |doi= 10.1093/emboj/17.10.2736 | pmc=1170614 |display-authors=etal}}
  • {{cite journal | vauthors=Kullmann M, Schneikert J, Moll J |title=RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14620–5 |year= 1998 |pmid= 9603979 |doi=10.1074/jbc.273.23.14620 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Liu R, Takayama S, Zheng Y |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16985–92 |year= 1998 |pmid= 9642262 |doi=10.1074/jbc.273.27.16985 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Takayama S, Krajewski S, Krajewska M |title=Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. |journal=Cancer Res. |volume=58 |issue= 14 |pages= 3116–31 |year= 1998 |pmid= 9679980 |display-authors=etal}}
  • {{cite journal | vauthors=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781–6 |year= 1999 |pmid= 9873016 |doi=10.1074/jbc.274.2.781 |doi-access=free }}
  • {{cite journal | vauthors=Yang X, Pater A, Tang SC |title=Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. |journal=Oncogene |volume=18 |issue= 32 |pages= 4546–53 |year= 1999 |pmid= 10467399 |doi= 10.1038/sj.onc.1202843 |doi-access= free }}
  • {{cite journal | vauthors=Schneikert J, Hübner S, Martin E, Cato AC |title=A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 929–40 |year= 1999 |pmid= 10477749 |doi=10.1083/jcb.146.5.929 | pmc=2169481 }}
  • {{cite journal | vauthors=Lüders J, Demand J, Höhfeld J |title=The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4613–7 |year= 2000 |pmid= 10671488 |doi=10.1074/jbc.275.7.4613 |doi-access=free }}

{{Refend}}

{{PDB Gallery|geneid=573}}

Category:Ageing

Category:Oncogenes

Category:Aging-related genes

Category:Aging-related proteins

Category:Co-chaperones