BAG5

{{Short description|Protein-coding gene in the species Homo sapiens}}

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.{{cite journal | vauthors = Takayama S, Xie Z, Reed JC | title = An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators | journal = J Biol Chem | volume = 274 | issue = 2 | pages = 781–6 |date=Feb 1999 | pmid = 9873016 | doi =10.1074/jbc.274.2.781 | doi-access = free }}{{cite journal | vauthors = Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM | title = BAG5 inhibits parkin and enhances dopaminergic neuron degeneration | journal = Neuron | volume = 44 | issue = 6 | pages = 931–45 |date=Dec 2004 | pmid = 15603737 | doi = 10.1016/j.neuron.2004.11.026 | doi-access = free }}{{cite web | title = Entrez Gene: BAG5 BCL2-associated athanogene 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9529}}

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

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{{UCSC gene info|BAG5}}

{{cite journal | vauthors=Takayama S, Sato T, Krajewski S |title=Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity |journal=Cell |volume=80 |issue= 2 |pages= 279–84 |year= 1995 |pmid= 7834747 |doi=10.1016/0092-8674(95)90410-7 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal | vauthors=Höhfeld J, Jentsch S |title=GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1 |journal=EMBO J. |volume=16 |issue= 20 |pages= 6209–16 |year= 1997 |pmid= 9321400 |doi= 10.1093/emboj/16.20.6209 | pmc=1326305 }}
{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
{{cite journal | vauthors=Nagase T, Ishikawa K, Suyama M |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=10.1093/dnares/5.6.355 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

BAG5

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Further reading