BAIAP2

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function.{{cite web | title = Entrez Gene: BAIAP2 BAI1-associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10458}}

BAIAP2 has been shown to interact with:

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• ATN1,{{cite journal | date = June 1999 | vauthors = Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M | title = Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate | journal = Hum. Mol. Genet. | volume = 8 | issue = 6 | pages = 947–57 | pmid = 10332026 | doi = 10.1093/hmg/8.6.947| doi-access = free }}
• CDC42,{{cite journal | date = October 2001 | vauthors = Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A | title = Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex | journal = Curr. Biol. | volume = 11 | issue = 21 | pages = 1645–55 | pmid = 11696321 | doi = 10.1016/S0960-9822(01)00506-1| s2cid = 11290377 | doi-access = free }}
• EPS8,{{cite journal | date = October 2005 | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | pmid = 16189514 | doi = 10.1038/nature04209| bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}{{cite journal | date = August 2004 | vauthors = Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H | title = IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness | journal = Cancer Res. | volume = 64 | issue = 15 | pages = 5237–44 | pmid = 15289329 | doi = 10.1158/0008-5472.CAN-04-0327| s2cid = 9844872 }}
• RAC1,
• SHANK1,{{cite journal | date = Dec 2002 | vauthors = Soltau M, Richter D, Kreienkamp HJ | title = The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 | journal = Mol. Cell. Neurosci. | volume = 21 | issue = 4 | pages = 575–83 | pmid = 12504591 | doi = 10.1006/mcne.2002.1201| s2cid = 572407 }}
• WASF1,{{cite journal | date = Dec 2000 | vauthors = Miki H, Yamaguchi H, Suetsugu S, Takenawa T | title = IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling | journal = Nature | volume = 408 | issue = 6813 | pages = 732–5 | pmid = 11130076 | doi = 10.1038/35047107| bibcode = 2000Natur.408..732M | s2cid = 4426046 }} and
• WASF2.

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{{Reflist}}

• {{UCSC gene info|BAIAP2}}

{{Refbegin | 2}}

• {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
• {{cite journal | vauthors=Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M |title=Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate |journal=Hum. Mol. Genet. |volume=8 |issue= 6 |pages= 947–57 |year= 1999 |pmid= 10332026 |doi=10.1093/hmg/8.6.947 |doi-access=free }}
• {{cite journal | vauthors=Abbott MA, Wells DG, Fallon JR |title=The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses |journal=J. Neurosci. |volume=19 |issue= 17 |pages= 7300–8 |year= 1999 |pmid= 10460236 |doi= 10.1523/JNEUROSCI.19-17-07300.1999|pmc=6782521 |doi-access=free }}
• {{cite journal | vauthors=Fujiwara T, Mammoto A, Kim Y, Takai Y |title=Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2 |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 626–9 |year= 2000 |pmid= 10814512 |doi= 10.1006/bbrc.2000.2671 }}
• {{cite journal | vauthors=Miki H, Yamaguchi H, Suetsugu S, Takenawa T |title=IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling |journal=Nature |volume=408 |issue= 6813 |pages= 732–5 |year= 2001 |pmid= 11130076 |doi= 10.1038/35047107 |bibcode= 2000Natur.408..732M |s2cid=4426046 }}
• {{cite journal | vauthors=Govind S, Kozma R, Monfries C |title=Cdc42hs Facilitates Cytoskeletal Reorganization and Neurite Outgrowth by Localizing the 58-Kd Insulin Receptor Substrate to Filamentous Actin |journal=J. Cell Biol. |volume=152 |issue= 3 |pages= 579–94 |year= 2001 |pmid= 11157984 |doi=10.1083/jcb.152.3.579 | pmc=2195994 |display-authors=etal}}
• {{cite journal | vauthors=Krugmann S, Jordens I, Gevaert K |title=Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1645–55 |year= 2002 |pmid= 11696321 |doi=10.1016/S0960-9822(01)00506-1 |s2cid=11290377 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Miki H, Takenawa T |title=WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 93–9 |year= 2002 |pmid= 12054568 |doi= 10.1016/S0006-291X(02)00218-8 }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}
• {{cite journal | vauthors=Soltau M, Richter D, Kreienkamp HJ |title=The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 575–83 |year= 2003 |pmid= 12504591 |doi=10.1006/mcne.2002.1201 |s2cid=572407 }}
• {{cite journal | vauthors=Sekerková G, Loomis PA, Changyaleket B |title=Novel Espin Actin-bundling Proteins Are Localized to Purkinje Cell Dendritic Spines and Bind the SH3 Adapter Protein Insulin Receptor Substrate p53 |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1310–9 |year= 2003 |pmid= 12598619 |doi= 10.1523/JNEUROSCI.23-04-01310.2003| pmc=2854510 |display-authors=etal}}
• {{cite journal | vauthors=Miyahara A, Okamura-Oho Y, Miyashita T |title=Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein |journal=J. Hum. Genet. |volume=48 |issue= 8 |pages= 410–4 |year= 2003 |pmid= 12884081 |doi= 10.1007/s10038-003-0047-x |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Hori K, Konno D, Maruoka H, Sobue K |title=MALS is a binding partner of IRSp53 at cell-cell contacts |journal=FEBS Lett. |volume=554 |issue= 1–2 |pages= 30–4 |year= 2003 |pmid= 14596909 |doi=10.1016/S0014-5793(03)01074-3 |s2cid=30329043 |doi-access=free }}
• {{cite journal | vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |display-authors=etal}}
• {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Yamagishi A, Masuda M, Ohki T |title=A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14929–36 |year= 2004 |pmid= 14752106 |doi= 10.1074/jbc.M309408200 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Funato Y, Terabayashi T, Suenaga N |title=IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness |journal=Cancer Res. |volume=64 |issue= 15 |pages= 5237–44 |year= 2004 |pmid= 15289329 |doi= 10.1158/0008-5472.CAN-04-0327 |s2cid=9844872 |display-authors=etal}}
• {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free }}

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