BANP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protein BANP is a protein that can be found in humans, it is encoded by the BANP gene.{{cite journal | vauthors = Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud J, Rouault J | title = Identification and molecular analysis of BANP | journal = Gene | volume = 253 | issue = 2 | pages = 189–96 | date = Aug 2000 | pmid = 10940556 | doi = 10.1016/S0378-1119(00)00244-4 }}{{cite journal | vauthors = Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J | title = SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus | journal = Genomics | volume = 68 | issue = 1 | pages = 93–6 | date = Aug 2000 | pmid = 10950932 | doi = 10.1006/geno.2000.6279 }}{{cite web | title = Entrez Gene: BANP BTG3 associated nuclear protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54971}} It is a member of the human gene family, "BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process.{{Cite web |title=National Center for Biotechnology Information |url=https://www.ncbi.nlm.nih.gov/ |access-date=2022-05-05 |website=www.ncbi.nlm.nih.gov |language=en}} In recombination BANP protein represses T-cell receptors to control recombination during transcription.{{Cite web |url=https://www.nextprot.org/entry/NX_Q8N9N5/#! |access-date=2022-05-05 |website=www.nextprot.org}} As a tumor suppressor BANP negatively regulates p53 transcription in recombination.{{Cite web |title=BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/54971 |access-date=2022-05-05 |website=www.ncbi.nlm.nih.gov}} It can be expressed in various tissues in the body including the testis, spleen, and the placenta.{{Cite web |title=BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/54971#gene-expression |access-date=2022-05-05 |website=www.ncbi.nlm.nih.gov}}
Function
This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
References
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External links
- {{UCSC gene info|BANP}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = Sep 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 | doi-access = free }}
- {{cite journal | vauthors = Kaul R, Mukherjee S, Ahmed F, Bhat MK, Chhipa R, Galande S, Chattopadhyay S | title = Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice | journal = International Journal of Cancer | volume = 103 | issue = 5 | pages = 606–15 | date = Feb 2003 | pmid = 12494467 | doi = 10.1002/ijc.10881 | s2cid = 22386279 | doi-access = free }}
- {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
- {{cite journal | vauthors = Kaul-Ghanekar R, Jalota A, Pavithra L, Tucker P, Chattopadhyay S | title = SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta) | journal = Nucleic Acids Research | volume = 32 | issue = 16 | pages = 4862–75 | year = 2004 | pmid = 15371550 | pmc = 519105 | doi = 10.1093/nar/gkh807 }}
- {{cite journal | vauthors = Kaul-Ghanekar R, Majumdar S, Jalota A, Gulati N, Dubey N, Saha B, Chattopadhyay S | title = Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice | journal = The Journal of Biological Chemistry | volume = 280 | issue = 10 | pages = 9450–9 | date = Mar 2005 | pmid = 15623522 | doi = 10.1074/jbc.M412206200 | doi-access = free }}
- {{cite journal | vauthors = Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S | title = Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex | journal = Molecular and Cellular Biology | volume = 25 | issue = 19 | pages = 8415–29 | date = Oct 2005 | pmid = 16166625 | pmc = 1265755 | doi = 10.1128/MCB.25.19.8415-8429.2005 }}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
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