BAT2

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.{{cite web | title = Entrez Gene: BAT2 HLA-B associated transcript 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7916}}

BAT2 has been shown to interact with:

• C1QBP,
• EIF3S6,
• HNRNPA1,
• IFT88,{{cite journal | date = Jan 2004 | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0}}
• IMMT, and
• UBAP2L.

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{{refbegin | 2}}

• {{cite journal | vauthors=Spies T, Bresnahan M, Strominger JL |title=Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8955–8 |year= 1989 |pmid= 2813433 |doi=10.1073/pnas.86.22.8955 | pmc=298409 |bibcode=1989PNAS...86.8955S |doi-access=free }}
• {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
• {{cite journal | vauthors=Singal DP, Li J, Zhu Y |title=HLA class III region and susceptibility to rheumatoid arthritis |journal=Clin. Exp. Rheumatol. |volume=18 |issue= 4 |pages= 485–91 |year= 2000 |pmid= 10949724 }}
• {{cite journal | vauthors=Hashimoto M, Nakamura N, Obayashi H |title=Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus |journal=Hum. Genet. |volume=105 |issue= 3 |pages= 197–9 |year= 2000 |pmid= 10987645 |doi=10.1007/s004390051089 |doi-broken-date=2024-11-02 |display-authors=etal}}
• {{cite journal | vauthors=Matsuzaka Y, Makino S, Nakajima K |title=New polymorphic microsatellite markers in the human MHC class III region |journal=Tissue Antigens |volume=57 |issue= 5 |pages= 397–404 |year= 2002 |pmid= 11556964 |doi=10.1034/j.1399-0039.2001.057005397.x |display-authors=etal}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Xie T, Rowen L, Aguado B |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 |display-authors=etal}}
• {{cite journal | vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |display-authors=etal}}
• {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Schneiders A, Thiel S, Winkler J |title=Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide |journal=Vaccine |volume=23 |issue= 19 |pages= 2540–50 |year= 2005 |pmid= 15752841 |doi= 10.1016/j.vaccine.2004.08.003 |display-authors=etal}}
• {{cite journal | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
• {{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
• {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

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• {{UCSC gene info|PRRC2A}}

{{protein-stub}}