BCAR3

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.

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• {{UCSC gene info|BCAR3}}

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• {{cite journal | vauthors=Vervoort VS, Roselli S, Oshima RG, Pasquale EB |title=Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |journal=Gene |volume=391 |issue= 1–2 |pages= 161–70 |year= 2007 |pmid= 17270363 |doi= 10.1016/j.gene.2006.12.016 | pmc=1876674 }}
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• {{cite journal | vauthors=Near RI, Zhang Y, Makkinje A |title=AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. |journal=J. Cell. Physiol. |volume=212 |issue= 3 |pages= 655–65 |year= 2007 |pmid= 17427198 |doi= 10.1002/jcp.21059 | pmc=2640322 |display-authors=etal}}
• {{cite journal | vauthors=Schrecengost RS, Riggins RB, Thomas KS |title=Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. |journal=Cancer Res. |volume=67 |issue= 13 |pages= 6174–82 |year= 2007 |pmid= 17616674 |doi= 10.1158/0008-5472.CAN-06-3455 |display-authors=etal|pmc=4109708 }}

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