BCAS1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.{{cite journal | vauthors = Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW | title = Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 15 | pages = 8703–8 |date=Aug 1998 | pmid = 9671742 | pmc = 21140 | doi =10.1073/pnas.95.15.8703 | bibcode = 1998PNAS...95.8703C | doi-access = free }}{{cite web | title = Entrez Gene: BCAS1 breast carcinoma amplified sequence 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8537}}
Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.
References
{{reflist}}
External links
- {{UCSC gene info|BCAS1}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Tanner MM, Tirkkonen M, Kallioniemi A |title=Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer |journal=Cancer Res. |volume=56 |issue= 15 |pages= 3441–5 |year= 1996 |pmid= 8758909 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Correa RG, de Carvalho AF, Pinheiro NA |title=NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors |journal=Genomics |volume=65 |issue= 3 |pages= 299–302 |year= 2000 |pmid= 10857754 |doi= 10.1006/geno.2000.6172 |display-authors=etal}}
- {{cite journal | vauthors=Lo KW, Naisbitt S, Fan JS |title=The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14059–66 |year= 2001 |pmid= 11148209 |doi= 10.1074/jbc.M010320200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Beardsley DI, Kowbel D, Lataxes TA |title=Characterization of the novel amplified in breast cancer-1 (NABC1) gene product |journal=Exp. Cell Res. |volume=290 |issue= 2 |pages= 402–13 |year= 2003 |pmid= 14567997 |doi=10.1016/S0014-4827(03)00353-7 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
{{refend}}
{{gene-20-stub}}