BCLAF1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res | volume = 3 | issue = 1 | pages = 17–24 |date=Nov 1996 | pmid = 8724849 | doi =10.1093/dnares/3.1.17 | doi-access = free }}{{cite journal | vauthors = Kasof GM, Goyal L, White E | title = Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins | journal = Mol Cell Biol | volume = 19 | issue = 6 | pages = 4390–404 |date=Jun 1999 | pmid = 10330179 | pmc = 104398 | doi = 10.1128/mcb.19.6.4390}}{{cite web | title = Entrez Gene: BCLAF1 BCL2-associated transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9774}}
This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different protein isoforms have been found for this gene.
References
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Further reading
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- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Haraguchi T, Holaska JM, Yamane M |title=Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery–Dreifuss muscular dystrophy |journal=Eur. J. Biochem. |volume=271 |issue= 5 |pages= 1035–45 |year= 2004 |pmid= 15009215 |doi=10.1111/j.1432-1033.2004.04007.x |display-authors=etal}}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Zheng H, Hu P, Quinn DF, Wang YK |title=Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 721–30 |year= 2005 |pmid= 15659558 |doi= 10.1074/mcp.M400077-MCP200 |doi-access= free }}
- {{cite journal | vauthors=Mansharamani M, Wilson KL |title=Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13863–70 |year= 2005 |pmid= 15681850 |doi= 10.1074/jbc.M413020200 |doi-access= free }}
- {{cite journal | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
- {{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Liu H, Lu ZG, Miki Y, Yoshida K |title=Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage |journal=Mol. Cell. Biol. |volume=27 |issue= 24 |pages= 8480–91 |year= 2007 |pmid= 17938203 |doi= 10.1128/MCB.01126-07 | pmc=2169390 }}
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External links
- {{FactorBook|BCLAF1}}
- {{UCSC gene info|BCLAF1}}
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