BIIB131

{{Orphan|date=March 2024}}

{{Chembox

| IUPACName = (2S)-2,5-bis[(2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-3,5-dihydroxy-2-methyl-7-oxo-4,9-dihydro-3H-pyrano[2,3-e]isoindol-8-yl]pentanoic acid

| OtherNames = {{unbulleted list|

• SMTP-7
• TMS-007

}}

| ImageFile = BIIB131.png

|Section1={{Chembox Identifiers

| PubChem = 50898407

| StdInChI=1S/C51H68N2O10/c1-30(2)14-9-16-32(5)18-11-21-50(7)43(56)26-36-41(54)24-34-38(45(36)62-50)28-52(47(34)58)23-13-20-40(49(60)61)53-29-39-35(48(53)59)25-42(55)37-27-44(57)51(8,63-46(37)39)22-12-19-33(6)17-10-15-31(3)4/h14-15,18-19,24-25,40,43-44,54-57H,9-13,16-17,20-23,26-29H2,1-8H3,(H,60,61)/b32-18+,33-19+/t40-,43-,44-,50-,51-/m0/s1

| StdInChIKey = CRNDCHORWGDFGR-PXTWCNKMSA-N

| SMILES = CC(=CCC/C(=C/CC[C@]1([C@H](CC2=C(C=C3C(=C2O1)CN(C3=O)CCC[C@@H](C(=O)O)N4CC5=C6C(=C(C=C5C4=O)O)C[C@@H]([C@](O6)(C)CC/C=C(\C)/CCC=C(C)C)O)O)O)C)/C)C

}}

|Section2={{Chembox Properties

| C=51|H=68|N=2|O=10

}}

|Section8={{Chembox Related

}}

}}

BIIB131 (also known as SMTP-7 or TMS-007) is a prothrombolytic small-molecule drug developed by Biogen for acute ischemic stroke.{{cite journal |last1=Yuan |first1=Long |last2=Jiang |first2=Di |last3=Pinkham |first3=Andrew |last4=Kirkland |first4=Melissa |title=Development, validation and application of a capillary microsampling LC–MS/MS method for the quantification of BIIB131 (SMTP-7) in rat plasma |journal=Journal of Pharmaceutical and Biomedical Analysis |date=November 2023 |volume=236 |pages=115752 |doi=10.1016/j.jpba.2023.115752|pmid=37769527 |doi-access=free }}{{cite journal |last1=Kostrubsky |first1=Vick |last2=Liu |first2=Ying |last3=Muste |first3=Cathy |last4=Gu |first4=Chungang |last5=Kirkland |first5=Melissa |last6=Nishimura |first6=Naoko |last7=Hasegawa |first7=Keiko |last8=Hasumi |first8=Keiji |last9=Yuan |first9=Long |title=Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke |journal=Regulatory Toxicology and Pharmacology |date=December 2023 |volume=145 |pages=105498 |doi=10.1016/j.yrtph.2023.105498|pmid=37778433 |s2cid=263297651 |doi-access=free }}{{cite journal |last1=Wang |first1=Bo |last2=Lin |first2=Yiqing |title=Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED) |journal=Chemical Communications |date=2022 |volume=58 |issue=94 |pages=13071–13074 |doi=10.1039/D2CC05218K |pmid=36305866 |s2cid=253184088 |url=https://pubs.rsc.org/en/content/articlehtml/2022/cc/d2cc05218k |language=en|doi-access=free }}