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BIRC7

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.{{cite journal | vauthors = Kasof GM, Gomes BC | title = Livin, a novel inhibitor of apoptosis protein family member | journal = J Biol Chem | volume = 276 | issue = 5 | pages = 3238–46 |date=May 2001 | pmid = 11024045 | doi = 10.1074/jbc.M003670200 | doi-access = free }}{{cite journal | vauthors = Lin JH, Deng G, Huang Q, Morser J | title = KIAP, a novel member of the inhibitor of apoptosis protein family | journal = Biochem Biophys Res Commun | volume = 279 | issue = 3 | pages = 820–31 |date=Feb 2001 | pmid = 11162435 | doi = 10.1006/bbrc.2000.4027 }}{{cite web | title = Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79444}}

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.{{cite journal | author = Dynek JN | title = Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas | journal = Cancer Res. | volume = 68 | issue = 9 | pages = 3124–32 | year = 2008 | pmid = 18451137 | doi = 10.1158/0008-5472.CAN-07-6622 |name-list-style=vanc| author2 = Chan SM | author3 = Liu J | display-authors = 3 | last4 = Zha | first4 = J. | last5 = Fairbrother | first5 = W. J. | last6 = Vucic | first6 = D. | doi-access = free }}{{cite journal | author = Hoek KS | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971| doi = 10.1111/j.1755-148X.2008.00505.x |name-list-style=vanc| author2 = Schlegel NC | author3 = Eichhoff OM | display-authors = 3 | last4 = Widmer | first4 = Daniel S. | last5 = Praetorius | first5 = Christian | last6 = Einarsson | first6 = Steingrimur O. | last7 = Valgeirsdottir | first7 = Sigridur | last8 = Bergsteinsdottir | first8 = Kristin | last9 = Schepsky | first9 = Alexander | s2cid = 24698373 | doi-access = free }}

References

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External links

  • {{UCSC gene info|BIRC7}}

Further reading

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  • {{cite journal | author=Bavykin AS |title=Double siRNA-targeting of cIAP2 and LIVIN results in synergetic sensitization of HCT-116 cells to oxaliplatin treatment |journal=OncoTargets Ther |issue= 6 |pages= 1333–40 |year= 2013 | pmc=3789649 |doi=10.2147/OTT.S44893 |name-list-style=vanc| author2=Korotaeva AA | author3=Poyarkov SV | display-authors=3 | last4=Syrtsev AV | first4=Tjulandin SA | last5=Karpukhin AV | pmid=24098083 | volume=6 |doi-access=free }}
  • {{cite journal | author=Vucic D |title=ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1359–66 |year= 2001 |pmid= 11084335 |doi=10.1016/S0960-9822(00)00781-8 |name-list-style=vanc| author2=Stennicke HR | author3=Pisabarro MT | display-authors=3 | last4=Salvesen | first4=Guy S. | last5=Dixit | first5=Vishva M. |s2cid=10381671 |doi-access=free}}
  • {{cite journal | author=Ashhab Y |title=Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern |journal=FEBS Lett. |volume=495 |issue= 1–2 |pages= 56–60 |year= 2001 |pmid= 11322947 |doi=10.1016/S0014-5793(01)02366-3 |name-list-style=vanc| author2=Alian A | author3=Polliack A | display-authors=3 | last4=Panet | first4=A | last5=Ben Yehuda | first5=D |s2cid=46380628 }}
  • {{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-style=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. |bibcode=2001Natur.414..865D | doi-access=free }}
  • {{cite journal | author=Vucic D |title=SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP) |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12275–9 |year= 2002 |pmid= 11801603 |doi= 10.1074/jbc.M112045200 |name-list-style=vanc| author2=Deshayes K | author3=Ackerly H | display-authors=3 | last4=Pisabarro | first4=MT | last5=Kadkhodayan | first5=S | last6=Fairbrother | first6=WJ | last7=Dixit | first7=VM | doi-access=free }}
  • {{cite journal | author=Sanna MG |title=IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1754–66 |year= 2002 |pmid= 11865055 |doi=10.1128/MCB.22.6.1754-1766.2002 | pmc=135597 |name-list-style=vanc| author2=da Silva Correia J | author3=Ducrey O | display-authors=3 | last4=Lee | first4=J. | last5=Nomoto | first5=K. | last6=Schrantz | first6=N. | last7=Deveraux | first7=Q. L. | last8=Ulevitch | first8=R. J. }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Gazzaniga P |title=Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer |journal=Ann. Oncol. |volume=14 |issue= 1 |pages= 85–90 |year= 2003 |pmid= 12488298 |doi=10.1093/annonc/mdg002 |name-list-style=vanc| author2=Gradilone A | author3=Giuliani L | display-authors=3 | last4=Gandini | first4=O | last5=Silvestri | first5=I | last6=Nofroni | first6=I | last7=Saccani | first7=G | last8=Frati | first8=L | last9=Aglianò | first9=AM | doi-access=free }}
  • {{cite journal | author=Clark HF |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-style=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}
  • {{cite journal | vauthors=Crnkovic-Mertens I, Hoppe-Seyler F, Butz K |title=Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene |journal=Oncogene |volume=22 |issue= 51 |pages= 8330–6 |year= 2004 |pmid= 14614456 |doi= 10.1038/sj.onc.1206973 |s2cid=21897515 |doi-access= }}
  • {{cite journal | vauthors=Andersen MH, Reker S, Becker JC, ((thor Straten P)) |title=The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 392–9 |year= 2004 |pmid= 15009721 |doi= 10.1046/j.0022-202X.2004.22242.x |doi-access= free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Tanabe H |title=Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer |journal=Lung Cancer |volume=46 |issue= 3 |pages= 299–304 |year= 2005 |pmid= 15541814 |doi= 10.1016/j.lungcan.2004.05.002 |name-list-style=vanc| author2=Yagihashi A | author3=Tsuji N | display-authors=3 | last4=Shijubo | first4=Y | last5=Abe | first5=S | last6=Watanabe | first6=N }}
  • {{cite journal | author=Yagihashi A |title=Detection of autoantibodies to survivin and livin in sera from patients with breast cancer |journal=Clin. Chim. Acta |volume=362 |issue= 1–2 |pages= 125–30 |year= 2006 |pmid= 16026775 |doi= 10.1016/j.cccn.2005.06.009 |name-list-style=vanc| author2=Ohmura T | author3=Asanuma K | display-authors=3 | last4=Kobayashi | first4=D | last5=Tsuji | first5=N | last6=Torigoe | first6=T | last7=Sato | first7=N | last8=Hirata | first8=K | last9=Watanabe | first9=N }}
  • {{cite journal | vauthors=Crnković-Mertens I, Semzow J, Hoppe-Seyler F, Butz K |title=Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells |journal=J. Mol. Med. |volume=84 |issue= 3 |pages= 232–40 |year= 2006 |pmid= 16437214 |doi= 10.1007/s00109-005-0021-5 |s2cid=28468027 }}
  • {{cite journal | author=Ma L |title=Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway |journal=Cell Death Differ. |volume=13 |issue= 12 |pages= 2079–88 |year= 2007 |pmid= 16729033 |doi= 10.1038/sj.cdd.4401959 |name-list-style=vanc| author2=Huang Y | author3=Song Z | display-authors=3 | last4=Feng | first4=S | last5=Tian | first5=X | last6=Du | first6=W | last7=Qiu | first7=X | last8=Heese | first8=K | last9=Wu | first9=M | doi-access=free }}
  • {{cite journal | author=Yan H |title=Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase |journal=J. Dermatol. Sci. |volume=43 |issue= 3 |pages= 189–200 |year= 2006 |pmid= 16806840 |doi= 10.1016/j.jdermsci.2006.05.007 | pmc=2292408 |name-list-style=vanc| author2=Brouha B | author3=Liu T | display-authors=3 | last4=Raj | first4=Deepak | last5=Biddle | first5=Diana | last6=Lee | first6=Ray | last7=Grossman | first7=Douglas }}
  • {{cite journal | author=Wu H |title=Expression of BIRC7 protein and mRNA in non-Hodgkin's lymphoma |journal=Leuk. Lymphoma |volume=47 |issue= 6 |pages= 1110–6 |year= 2007 |pmid= 16840203 |doi= 10.1080/10428190500472271 |name-list-style=vanc| author2=Ma Y | author3=Zhu Y | display-authors=3 | last4=Shen | first4=Yan | last5=Gu | first5=Congming | last6=Ye | first6=Ziyin | last7=Lin | first7=Hanliang |s2cid=24671993 }}
  • {{cite journal | author=Crnković-Mertens I |title=The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells |journal=Lung Cancer |volume=54 |issue= 2 |pages= 135–42 |year= 2007 |pmid= 16965834 |doi= 10.1016/j.lungcan.2006.07.018 |name-list-style=vanc| author2=Muley T | author3=Meister M | display-authors=3 | last4=Hartenstein | first4=B | last5=Semzow | first5=J | last6=Butz | first6=K | last7=Hoppeseyler | first7=F }}

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{{PDB Gallery|geneid=79444}}