BMP binding endothelial regulator
{{Short description|Protein-coding gene in the species Homo sapiens}}
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BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene.{{cite web | title = Entrez Gene: BMP binding endothelial regulator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=168667| accessdate = 2011-09-29 }}
Transcription
KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15.{{cite journal | vauthors = Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M | title = Krüppel-like factor 15 regulates BMPER in endothelial cells | journal = Cardiovascular Research | volume = 85 | issue = 3 | pages = 551–9 | date = Feb 2010 | pmid = 19767294 | doi = 10.1093/cvr/cvp314 | pmc = 4110462 }}
References
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External links
- {{UCSC gene info|BMPER}}
Further reading
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- {{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins | journal = DNA Research | volume = 8 | issue = 6 | pages = 319–27 | date = Dec 2001 | pmid = 11853319 | doi = 10.1093/dnares/8.6.319 | doi-access = free }}
- {{cite journal | vauthors = Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C | title = BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation | journal = Molecular and Cellular Biology | volume = 23 | issue = 16 | pages = 5664–79 | date = Aug 2003 | pmid = 12897139 | pmc = 166349 | doi = 10.1128/MCB.23.16.5664-5679.2003 }}
- {{cite journal | vauthors = Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F | title = Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins | journal = Biochemical and Biophysical Research Communications | volume = 315 | issue = 2 | pages = 272–80 | date = Mar 2004 | pmid = 14766204 | doi = 10.1016/j.bbrc.2004.01.048 }}
- {{cite journal | vauthors = Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M | title = BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis | journal = Circulation Research | volume = 103 | issue = 8 | pages = 804–12 | date = Oct 2008 | pmid = 18787191 | doi = 10.1161/CIRCRESAHA.108.178434 | doi-access = free }}
- {{cite journal | vauthors = Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH | title = BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing | journal = American Journal of Human Genetics | volume = 87 | issue = 4 | pages = 532–7 | date = Oct 2010 | pmid = 20869035 | pmc = 2948790 | doi = 10.1016/j.ajhg.2010.08.015 }}
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