BNIP3L

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.

BNIP3L has been shown to interact with STEAP3.{{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2284–9 | date = Mar 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 | bibcode = 2003PNAS..100.2284P | doi-access = free }}

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• {{UCSC gene info|BNIP3L}}

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• {{cite journal | vauthors = Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A | title = Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. | journal = J. Biol. Chem. | volume = 274 | issue = 1 | pages = 7–10 | year = 1999 | pmid = 9867803 | doi = 10.1074/jbc.274.1.7 | doi-access = free }}
• {{cite journal | vauthors = Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T | title = A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. | journal = Cell Death Differ. | volume = 6 | issue = 4 | pages = 314–25 | year = 1999 | pmid = 10381623 | doi = 10.1038/sj.cdd.4400493 | doi-access = free }}
• {{cite journal | vauthors = Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y | title = Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. | journal = Oncogene | volume = 18 | issue = 32 | pages = 4523–9 | year = 1999 | pmid = 10467396 | doi = 10.1038/sj.onc.1202722 | doi-access = free }}
• {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
• {{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2284–9 | year = 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 | bibcode = 2003PNAS..100.2284P | doi-access = free }}
• {{cite journal | vauthors = Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL | title = The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. | journal = Blood | volume = 102 | issue = 2 | pages = 712–7 | year = 2003 | pmid = 12663450 | doi = 10.1182/blood-2002-11-3324 | doi-access = free }}
• {{cite journal | vauthors = Sun JL, He XS, Yu YH, Chen ZC | title = [Expression and structure of BNIP3L in lung cancer] | journal = AI Zheng | volume = 23 | issue = 1 | pages = 8–14 | year = 2004 | pmid = 14720367 }}
• {{cite journal | vauthors = Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS | title = Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. | journal = Cancer Cell | volume = 6 | issue = 6 | pages = 597–609 | year = 2005 | pmid = 15607964 | doi = 10.1016/j.ccr.2004.10.012 | doi-access = free }}
• {{cite journal | vauthors = Stepan H, Leo C, Purz S, Höckel M, Horn LC | title = Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. | journal = Eur. J. Obstet. Gynecol. Reprod. Biol. | volume = 122 | issue = 2 | pages = 172–6 | year = 2006 | pmid = 16219518 | doi = 10.1016/j.ejogrb.2005.01.017 }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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