BRD2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals {{Cite journal
| pmid = 22722403
| pmc = 3934568
| year = 2012
| last1 = Belkina
| first1 = A. C.
| title = BET domain co-regulators in obesity, inflammation and cancer
| journal = Nature Reviews Cancer
| volume = 12
| issue = 7
| pages = 465–77
| last2 = Denis
| first2 = G. V.
| doi = 10.1038/nrc3256
}}{{cite journal | vauthors = Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S | title = Phylogeny and structure of the RING3 gene | journal = Immunogenetics | volume = 44 | issue = 5 | pages = 391–6 |date=October 1996 | pmid = 8781126 | doi =10.1007/BF02602785 | s2cid = 44613743 }}{{cite web | title = BRD2 bromodomain containing 2 [ Homo sapiens (human) ]| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6046}}
Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.
Functions
- BRD2 has been implicated in cancer.{{Cite journal
| pmid = 24905006
| pmc = 4236231
| year = 2014
| last1 = Shi
| first1 = J
| title = The mechanisms behind the therapeutic activity of BET bromodomain inhibition
| journal = Molecular Cell
| volume = 54
| issue = 5
| pages = 728–36
| last2 = Vakoc
| first2 = C. R.
| doi = 10.1016/j.molcel.2014.05.016
}}
- BRD2 loss in mice causes obesity without diabetes for unknown reasons.
- BRD2 may have functional overlap with close homolog BRD3.{{Cite journal
| pmid = 25696920
| year = 2015
| last1 = Stonestrom
| first1 = A. J.
| title = Functions of BET proteins in erythroid gene expression
| journal = Blood
| last2 = Hsu
| first2 = S. C.
| last3 = Jahn
| first3 = K. S.
| last4 = Huang
| first4 = P
| last5 = Keller
| first5 = C. A.
| last6 = Giardine
| first6 = B. M.
| last7 = Kadauke
| first7 = S
| last8 = Campbell
| first8 = A. E.
| last9 = Evans
| first9 = P
| last10 = Hardison
| first10 = R. C.
| last11 = Blobel
| first11 = G. A.
| doi = 10.1182/blood-2014-10-607309
| volume=125
| issue = 18
| pages=2825–34
| pmc=4424630
}}
- BRD2 function is blocked by BET inhibitors.
Interactions
BRD2 has been shown to interact with E2F2,{{cite journal |doi=10.1210/me.2001-0353 |last=Crowley |first=Thomas E |author2=Kaine Emily M |author3=Yoshida Manabu |author4=Nandi Anindita |author5=Wolgemuth Debra J |date=August 2002 |title=Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein |journal=Mol. Endocrinol. |volume=16 |issue=8 |pages=1727–37 |location = United States| issn = 0888-8809| pmid = 12145330 |doi-access=free }}{{cite journal |last=Denis |first=G V |author2=Vaziri C |author3=Guo N |author4=Faller D V |date=August 2000 |title=RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F |journal=Cell Growth Differ. |volume=11 |issue=8 |pages=417–24 |location = UNITED STATES| issn = 1044-9523| pmid = 10965846 | pmc=3968681}} and many transcription factors including GATA1.
References
{{reflist}}
External links
- {{UCSC gene info|BRD2}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Haynes SR, Dollard C, Winston F |title=The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. |journal=Nucleic Acids Res. |volume=20 |issue= 10 |pages= 2603 |year= 1992 |pmid= 1350857 |doi=10.1093/nar/20.10.2603 | pmc=312404 |display-authors=etal}}
- {{cite journal | vauthors=Okamoto N, Ando A, Kawai J |title=Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region. |journal=Hum. Immunol. |volume=32 |issue= 3 |pages= 221–8 |year= 1992 |pmid= 1663500 |doi=10.1016/0198-8859(91)90059-I |display-authors=etal}}
- {{cite journal | vauthors=Denis GV, Green MR |title=A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. |journal=Genes Dev. |volume=10 |issue= 3 |pages= 261–71 |year= 1996 |pmid= 8595877 |doi=10.1101/gad.10.3.261 |url=https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1597&context=oapubs |doi-access=free }}
- {{cite journal | vauthors=Thorpe KL, Gorman P, Thomas C |title=Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. |journal=Gene |volume=200 |issue= 1–2 |pages= 177–83 |year= 1997 |pmid= 9373153 |doi=10.1016/S0378-1119(97)00415-0 |display-authors=etal}}
- {{cite journal | vauthors=Taniguchi Y, Matsuzaka Y, Fujimoto H |title=Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells. |journal=Genomics |volume=51 |issue= 1 |pages= 114–23 |year= 1998 |pmid= 9693039 |doi= 10.1006/geno.1998.5262 |display-authors=etal}}
- {{cite journal | vauthors=Guo N, Faller DV, Denis GV |title=Activation-induced nuclear translocation of RING3. |journal=J. Cell Sci. |volume=113 |issue= 17|pages= 3085–91 |year= 2000 |doi=10.1242/jcs.113.17.3085 |pmid= 10934046 |pmc=3936601 }}
- {{cite journal | vauthors=Denis GV, Vaziri C, Guo N, Faller DV |title=RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. |journal=Cell Growth Differ. |volume=11 |issue= 8 |pages= 417–24 |year= 2001 |pmid= 10965846 |pmc=3968681}}
- {{cite journal | vauthors=BelAiba RS, Baril P, Chebloune Y |title=Identification and cloning of an 85-kDa protein homologous to RING3 that is upregulated in proliferating endothelial cells. |journal=Eur. J. Biochem. |volume=268 |issue= 16 |pages= 4398–407 |year= 2001 |pmid= 11502199 |doi=10.1046/j.1432-1327.2001.02355.x |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Crowley TE, Kaine EM, Yoshida M |title=Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. |journal=Mol. Endocrinol. |volume=16 |issue= 8 |pages= 1727–37 |year= 2003 |pmid= 12145330 |doi=10.1210/me.2001-0353 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Zhou M, Peng C, Nie XM |title=[Expression of BRD7-interacting proteins, BRD2 and BRD3, in nasopharyngeal carcinoma tissues] |journal=AI Zheng |volume=22 |issue= 2 |pages= 123–7 |year= 2003 |pmid= 12600283 |display-authors=etal}}
- {{cite journal | vauthors=Pal DK, Evgrafov OV, Tabares P |title=BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. |journal=Am. J. Hum. Genet. |volume=73 |issue= 2 |pages= 261–70 |year= 2003 |pmid= 12830434 |doi=10.1086/377006 | pmc=1180366 |display-authors=etal}}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal|doi-access=free |bibcode=2003Natur.425..805M }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Kanno T, Kanno Y, Siegel RM |title=Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. |journal=Mol. Cell |volume=13 |issue= 1 |pages= 33–43 |year= 2004 |pmid= 14731392 |doi=10.1016/S1097-2765(03)00482-9 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Benevolenskaya EV, Murray HL, Branton P |title=Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 623–35 |year= 2005 |pmid= 15949438 |doi= 10.1016/j.molcel.2005.05.012 |display-authors=etal|doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=6046}}
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