BRD7

BRD7 has been shown to interact with IRF2{{cite journal |last=Staal |first=A |author2=Enserink J M |author3=Stein J L |author4=Stein G S |author5=van Wijnen A J |date=November 2000 |title=Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 |journal=J. Cell. Physiol. |volume=185 |issue=2 |pages=269–279 |location = UNITED STATES| issn = 0021-9541| pmid = 11025449 |doi = 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L |s2cid=22932901 }} and HNRPUL1.{{cite journal |last=Kzhyshkowska |first=Julia |author2=Rusch Andre |author3=Wolf Hans |author4=Dobner Thomas |date=April 2003 |title=Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 |journal=Biochem. J. |volume=371 |issue=Pt 2 |pages=385–93 |location = England| issn = 0264-6021| pmid = 12489984 |doi = 10.1042/BJ20021281 |pmc=1223277 }}

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.{{cite journal |vauthors=Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M |title=Knockout of BRD7 results in impaired spermatogenesis and male infertility |journal=Sci Rep |volume=6 |pages=21776 |year=2016 |pmid=26878912 |pmc=4754950 |doi=10.1038/srep21776 |bibcode=2016NatSR...621776W }} Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.

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• {{UCSC gene info|BRD7}}

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