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BRMS1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.{{cite journal | vauthors = Seraj MJ, Samant RS, Verderame MF, Welch DR | title = Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 | journal = Cancer Research | volume = 60 | issue = 11 | pages = 2764–9 |date=Jun 2000 | pmid = 10850410 }}

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[https://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855}}

References

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External links

  • {{UCSC gene info|BRMS1}}

Further reading

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  • {{cite journal | vauthors=Meehan WJ, Welch DR |title=Breast cancer metastasis suppressor 1: update. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 45–50 |year= 2003 |pmid= 12650606 |doi=10.1023/A:1022542519586 |s2cid=26142383 }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal | vauthors=Samant RS, Debies MT, Shevde LA |title=Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |journal=Int. J. Cancer |volume=97 |issue= 1 |pages= 15–20 |year= 2002 |pmid= 11774238 |doi=10.1002/ijc.1569 |s2cid=19747938 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Shevde LA, Samant RS, Goldberg SF |title=Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. |journal=Exp. Cell Res. |volume=273 |issue= 2 |pages= 229–39 |year= 2002 |pmid= 11822878 |doi= 10.1006/excr.2001.5452 |display-authors=etal}}
  • {{cite journal | vauthors=Janneau JL, Maldonado-Estrada J, Tachdjian G |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Meehan WJ, Samant RS, Hopper JE |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562–9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Cicek M, Samant RS, Kinter M |title=Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells |journal=Clin. Exp. Metastasis |volume=21 |issue= 2 |pages= 149–57 |year= 2004 |pmid= 15168732 |doi=10.1023/B:CLIN.0000024729.19084.f0 |s2cid=19383717 |display-authors=etal}}
  • {{cite journal | vauthors=Nikolaev AY, Papanikolaou NA, Li M |title=Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1216–22 |year= 2004 |pmid= 15451426 |doi= 10.1016/j.bbrc.2004.08.227 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Stark AM, Tongers K, Maass N |title=Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases |journal=J. Cancer Res. Clin. Oncol. |volume=131 |issue= 3 |pages= 191–8 |year= 2005 |pmid= 15592684 |doi= 10.1007/s00432-004-0629-9 |s2cid=12411341 |display-authors=etal}}
  • {{cite journal | vauthors=DeWald DB, Torabinejad J, Samant RS |title=Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells |journal=Cancer Res. |volume=65 |issue= 3 |pages= 713–7 |year= 2005 |doi=10.1158/0008-5472.713.65.3 |pmid= 15705865 |s2cid=24886361 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Cicek M, Fukuyama R, Welch DR |title=Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3586–95 |year= 2005 |pmid= 15867352 |doi= 10.1158/0008-5472.CAN-04-3139 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hurst DR, Mehta A, Moore BP |title=Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 4 |pages= 1429–35 |year= 2006 |pmid= 16919237 |doi= 10.1016/j.bbrc.2006.08.005 | pmc=1557677 |display-authors=etal}}
  • {{cite journal | vauthors=Samant RS, Clark DW, Fillmore RA |title=Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation |journal=Mol. Cancer |volume=6 |pages= 6 |year= 2007 |pmid= 17227585 |doi= 10.1186/1476-4598-6-6 | pmc=1796551 |display-authors=etal |doi-access=free }}
  • {{cite journal | vauthors=Rivera J, Megias D, Bravo J |title=Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1 |journal=J. Proteome Res. |volume=6 |issue= 10 |pages= 4006–18 |year= 2007 |pmid= 17854218 |doi= 10.1021/pr0703167 }}

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