BYSL

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.

BYSL has been shown to interact with TROAP.{{cite journal | vauthors = Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN | title = A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 9 | pages = 5027–32 | date = Apr 1998 | pmid = 9560222 | pmc = 20207 | doi = 10.1073/pnas.95.9.5027 | bibcode = 1998PNAS...95.5027S | doi-access = free }}

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• {{UCSC gene info|BYSL}}

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• {{cite journal | vauthors = Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN | title = A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 9 | pages = 5027–32 | year = 1998 | pmid = 9560222 | pmc = 20207 | doi = 10.1073/pnas.95.9.5027 | bibcode = 1998PNAS...95.5027S | doi-access = free }}
• {{cite journal | vauthors = Suzuki N, Nakayama J, Shih IM, Aoki D, Nozawa S, Fukuda MN | title = Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. | journal = Biol. Reprod. | volume = 60 | issue = 3 | pages = 621–7 | year = 1999 | pmid = 10026108 | doi = 10.1095/biolreprod60.3.621 | doi-access = free }}
• {{cite journal | vauthors = Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda MN | title = Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. | journal = Am. J. Pathol. | volume = 163 | issue = 6 | pages = 2211–9 | year = 2004 | pmid = 14633596 | pmc = 1892375 | doi = 10.1016/S0002-9440(10)63579-1 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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{{DEFAULTSORT:Bysl}}

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