Bamipine

{{Short description|Chemical compound}}

{{Drugbox

| verifiedrevid = 437205596

| IUPAC_name = N-benzyl-1-methyl-N-phenyl-piperidin-4-amine

| image = Bamipine.svg

| tradename = Soventol

| Drugs.com = {{drugs.com|international|bamipine}}

| routes_of_administration = Oral?, topical

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 4945-47-5

| ATC_prefix = D04

| ATC_suffix = AA15

| ATC_supplemental = {{ATC|R06|AX01}}

| PubChem = 72075

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 65061

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = Y6BHZ28O92

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D07197

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 520400

| C=19 | H=24 | N=2

| smiles = N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = VZSXTYKGYWISGQ-UHFFFAOYSA-N

}}

Bamipine (trade name Soventol){{Cite book |last=Publishing |first=William Andrew |url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA523 |title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition |date=2013-10-22 |publisher=Elsevier |isbn=978-0-8155-1856-3 |page=523 |language=en}} is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties.{{cite book | vauthors = Vardanyan RS | chapter = Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines |title=Piperidine-based drug discovery |date=2017 |location=Amsterdam, Netherlands |isbn=978-0-12-813428-3 |page=191 | chapter-url=https://books.google.com/books?id=szxHDgAAQBAJ&dq=Bamipine&pg=PA191}} It is used as an antipruritic ointment.{{cite patent | country = WO | number = 0236163 |title = Pharmaceutical compositions containing tiotropium salts and antihistamines and their use |inventor = Pairet M, Pieper MP, Meade CJ, Schmelzer C | assign1 = Boehringer Ingelheim |pubdate = 10 May 2002 }} No oral use is known.{{drugs.com|international|bamipine}}: Bamipine.

Adverse effects

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.{{cite book|title=Austria-Codex|at=Soventol-Gel| veditors = Haberfeld H |publisher=Österreichischer Apothekerverlag|location=Vienna|year=2015|language=German}}

Contraindications and interactions

No clinically relevant contraindications or interactions with other drugs are known.

Pharmacology

=Pharmacokinetics=

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.

References

{{Reflist|1}}

{{Antipruritics}}

{{Antihistamines}}

{{Cholinergics}}

{{Histaminergics}}

Category:Piperidines

Category:H1 receptor antagonists