Bendazac
{{Short description|Chemical compound}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 447984244
| IUPAC_name = [(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
| image = Bendazac.svg
| image_class = skin-invert-image
| tradename =
| Drugs.com = {{drugs.com|international|bendazac}}
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration = Topical
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 20187-55-7
| ATC_prefix = M02
| ATC_suffix = AA11
| ATC_supplemental = {{ATC|S01|BC07}}
| PubChem = 2313
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2223
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = G4AG71204O
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01594
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 31257
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1089221
| C=16 | H=14
| N=2 | O=3
| smiles = O=C(O)COc2nn(c1ccccc12)Cc3ccccc3
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C16H14N2O3/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = BYFMCKSPFYVMOU-UHFFFAOYSA-N
}}
Bendazac (or bendazolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.{{cite journal | vauthors = Balfour JA, Clissold SP | title = Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts | journal = Drugs | volume = 39 | issue = 4 | pages = 575–96 | date = April 1990 | pmid = 2190795 | doi = 10.2165/00003495-199039040-00007 | s2cid = 46956362 }}
Synthesis
Principal action is inhibition of protein denaturation.
File:Bendazac synthesis.svg).]]
Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine).
See also
References
{{Reflist}}
{{NSAIDs}}
{{Topical products for joint and muscular pain}}
{{Prostanoidergics}}
Category:Nonsteroidal anti-inflammatory drugs
{{musculoskeletal-drug-stub}}
{{analgesic-stub}}