Binding coefficient

In medicinal chemistry and pharmacology, a binding coefficient is a quantity representing the extent to which a chemical compound will bind to a macromolecule.Schurr JM, Rangel DP, Aragon SR. (2005) [http://www.biophysj.org/cgi/content/full/89/4/2258 "A Contribution to the Theory of Preferential Interaction Coefficients."] {{webarchive |url=https://web.archive.org/web/20071011150218/http://www.biophysj.org/cgi/content/full/89/4/2258 |date=October 11, 2007 }} Biophysical Journal. 89:2258-2276.Shulgin IL, Ruckenstein E (2006) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367075/ "A Protein Molecule in a Mixed Solvent: The Preferential Binding Parameter via the Kirkwood-Buff theory."] Biophysical Journal. 90:704–707. The preferential binding coefficient can be derived from the Kirkwood-Buff solution theory of solutions. Preferential binding is defined as a thermodynamic expression that describes the binding of the cosolvent over the solvent. This is in a system that is open to both the solvent and cosolvent. Pierce V, Kang M, Weerasinghe S, Smith PE. (2008) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566781/ "Recent Applications of Kirkwood-Buff Theory to Biological Systems."] Cell Biochem Biophys. 50(1):1-22. Consequently, preferential interaction coefficients are measures of interactions that involve “solutes that participate in a reaction in solution.” Thomas Record Jr. M, Anderson CF. (1995) [http://ac.els-cdn.com/S0006349595802547/1-s2.0-S0006349595802547-main.pdf?_tid=49b2b2c6-4cb8-11e3-8196-00000aab0f27&acdnat=1384384194_226f73535656c79106cae9511103cd8e "Interpretation of Preferential Interaction Coefficients of Nonelectrolytes and of Electrolyte Ions in Terms of a Two-Domain Model."] Biophysical Journal. 68:786-794.