Blood vessel#Vessel size

• artery – late Middle English; from Latin arteria, from Greek artēria, probably from airein ("raise").{{Cite web |title=artery, noun |url=https://www.oxfordlearnersdictionaries.com/definition/english/arteriole |website=Oxford Learner's Dictionaries |at=Word Origin}}
• vein – Middle English; from Old French veine, from Latin vena.{{Cite web |title=Middle English Dictionary Entry of vein and veine |url=https://quod.lib.umich.edu/m/middle-english-dictionary/dictionary/MED50805 |website=Middle English Compendium}}
• capillary – mid-17th century; from Latin capillaris, from capillus ("hair"), influenced by Old French capillaire.{{Cite web |title=capillary, noun |url=https://www.oxfordlearnersdictionaries.com/definition/english/capillary |website=Oxford Learner's Dictionaries |at=Word Origin}}

The arteries and veins have three layers. The middle layer is thicker in the arteries than it is in the veins:{{Citation |last1=Taylor |first1=Anthony M. |title=Histology, Blood Vascular System |date=2024 |work=StatPearls |url=https://www.ncbi.nlm.nih.gov/books/NBK553217/ |access-date=2024-04-07 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31985998 |last2=Bordoni |first2=Bruno}}

• The inner layer, tunica intima, is the thinnest layer. It is a single layer of flat cells (simple squamous epithelium) glued by a polysaccharide intercellular matrix, surrounded by a thin layer of subendothelial connective tissue interlaced with a number of circularly arranged elastic bands called the internal elastic lamina. A thin membrane of elastic fibers in the tunica intima run parallel to the vessel.
• The middle layer of tunica media is the thickest layer in arteries. It consists of circularly arranged elastic fiber, connective tissue and polysaccharide substances; the second and third layer are separated by another thick elastic band called external elastic lamina.{{Cite journal |last1=Qin |first1=Guiping |last2=Wang |first2=Leiming |last3=Hua |first3=Yulan |last4=Hou |first4=Haina |last5=Zou |first5=Qiuju |last6=Wang |first6=Daye |last7=Hu |first7=Zijing |last8=Lu |first8=Dehong |date=2020-04-01 |title=Comparative morphology of the internal elastic lamina of cerebral and peripheral arteries |journal=International Journal of Clinical and Experimental Pathology |language=en |volume=13 |issue=4 |pages=764–770 |pmc=7191140 |pmid=32355525}} The tunica media may (especially in arteries) be rich in vascular smooth muscle, which controls the caliber of the vessel. Veins do not have the external elastic lamina, but only an internal one. The tunica media is thicker in the arteries rather than the veins.
• The outer layer is the tunica adventitia and the thickest layer in veins. It is entirely made of connective tissue. It also contains nerves that supply the vessel as well as nutrient capillaries (vasa vasorum) in the larger blood vessels.

Capillaries consist of a single layer of endothelial cells with a supporting subendothelium consisting of a basement membrane and connective tissue. When blood vessels connect to form a region of diffuse vascular supply, it is called an anastomosis. Anastomoses provide alternative routes for blood to flow through in case of blockages. Veins can have valves that prevent the backflow of the blood that was being pumped against gravity by the surrounding muscles.{{Cite web |last=D. Douketis |first=James |date=2023 |title=Overview of the Venous System |url=https://www.msdmanuals.com/home/heart-and-blood-vessel-disorders/venous-disorders/overview-of-the-venous-system |website=MSD Manual}} In humans, arteries do not have valves except for the two 'arteries' that originate from the heart's ventricles.The exception is the pulmonary artery and the aorta.

Early estimates by Danish physiologist August Krogh suggested that the total length of capillaries in human muscles could reach approximately {{convert|100000|km|mi}} (assuming a high muscle mass human body, like that of a bodybuilder).{{Cite book |last=Krogh |first=August |url=https://archive.org/details/anatomyphysiolog00kroguoft/page/10/mode/2up?q=length |title=The anatomy and physiology of capillaries |date=1922 |publisher=New Haven, Yale Univ. Press |others=Gerstein - University of Toronto}} However, later studies suggest a more conservative figure of {{convert|9000|-|19000|km|mi}} taking into account updated capillary density and average muscle mass in adults.{{Cite journal |last=Poole |first=David C. |last2=Kano |first2=Yutaka |last3=Koga |first3=Shunsaku |last4=Musch |first4=Timothy I. |date=2021|title=August Krogh: Muscle capillary function and oxygen delivery |journal=Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology |volume=253 |pages=110852 |doi=10.1016/j.cbpa.2020.110852 |issn=1531-4332 |pmc=7867635 |pmid=33242636}}

There are various kinds of blood vessels:{{Citation |last1=Tucker |first1=William D. |title=Anatomy, Blood Vessels |date=2024 |work=StatPearls |url=https://www.ncbi.nlm.nih.gov/books/NBK470401/ |access-date=2024-04-17 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=29262226 |last2=Arora |first2=Yingyot |last3=Mahajan |first3=Kunal}}

• Arteries
• Elastic arteries
• Distributing arteries
• Arterioles
• Capillaries (smallest type of blood vessels)
• Venules
• Veins
• Large collecting vessels, such as the subclavian vein, the jugular vein, the renal vein and the iliac vein.
• Venae cavae (the two largest veins, carry blood into the heart).
• Sinusoids
• Extremely small vessels located within bone marrow, the spleen and the liver.

They are roughly grouped as "arterial" and "venous", determined by whether the blood in it is flowing away from (arterial) or toward (venous) the heart. The term "arterial blood" is nevertheless used to indicate blood high in oxygen, although the pulmonary artery carries "venous blood" and blood flowing in the pulmonary vein is rich in oxygen. This is because they are carrying the blood to and from the lungs, respectively, to be oxygenated.{{cn|date=February 2024}}

{{See also|Circulatory system}}

Blood vessels function to transport blood to an animal's body tissues. In general, arteries and arterioles transport oxygenated blood from the lungs to the body and its organs, and veins and venules transport deoxygenated blood from the body to the lungs. Blood vessels also circulate blood throughout the circulatory system. Oxygen (bound to hemoglobin in red blood cells) is the most critical nutrient carried by the blood. In all arteries apart from the pulmonary artery, hemoglobin is highly saturated (95–100%) with oxygen. In all veins, apart from the pulmonary vein, the saturation of hemoglobin is about 75%.{{Cite web|title= Central Venous/Mixed Venous Oxygen Saturation |url=https://www.lhsc.on.ca/critical-care-trauma-centre/central-venous/mixed-venous-oxygen-saturation|access-date=2021-08-08 | location = London, Ontario, CA | work = London Health Sciences Centre }}{{Cite web|title=Hypoxemia (low blood oxygen)|url=https://www.mayoclinic.org/symptoms/hypoxemia/basics/definition/sym-20050930|access-date=2021-08-08|website=Mayo Clinic|language=en}} (The values are reversed in the pulmonary circulation.) In addition to carrying oxygen, blood also carries hormones, and nutrients to the cells of a body and removes waste products.{{Cite journal |last=Prisby |first=Rhonda D. |date=2017-08-16 |title=Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone |journal=The Journal of Endocrinology |language=en |volume=235 |issue=3 |pages=R77–R100 |doi=10.1530/JOE-16-0666 |pmc=5611884 |pmid=28814440}}

Blood vessels do not actively engage in the transport of blood (they have no appreciable peristalsis). Blood is propelled through arteries and arterioles through pressure generated by the heartbeat.{{cite encyclopedia | vauthors = Khan MG | title=Anatomy of the Heart and Circulation |encyclopedia=Encyclopedia of Heart Disease |year=2006 |publisher=Academic Press |location=Amsterdam | isbn = 978-0-08-045481-8 | pages = 13–22 | url = https://books.google.com/books?id=xco9aJ_Y9XIC&pg=PR13 }} Blood vessels also transport red blood cells. Hematocrit tests can be performed to calculate the proportion of red blood cells in the blood. Higher proportions result in conditions such as dehydration or heart disease, while lower proportions could lead to anemia and long-term blood loss.{{cite web|url=https://www.mayoclinic.org/tests-procedures/hematocrit/about/pac-20384728|title=Hematocrit test – Mayo Clinic|website=www.mayoclinic.org}}

Permeability of the endothelium is pivotal in the release of nutrients to the tissue. It is also increased in inflammation in response to histamine,{{Cite journal |last1=Ashina |first1=Kohei |last2=Tsubosaka |first2=Yoshiki |last3=Nakamura |first3=Tatsuro |last4=Omori |first4=Keisuke |last5=Kobayashi |first5=Koji |last6=Hori |first6=Masatoshi |last7=Ozaki |first7=Hiroshi |last8=Murata |first8=Takahisa |date=2015 |title=Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo |journal=PLOS ONE |volume=10 |issue=7 |pages=e0132367 |doi=10.1371/journal.pone.0132367 |issn=1932-6203 |pmc=4497677 |pmid=26158531 |doi-access=free}} prostaglandins{{Cite journal |last1=Rittchen |first1=Sonja |last2=Rohrer |first2=Kathrin |last3=Platzer |first3=Wolfgang |last4=Knuplez |first4=Eva |last5=Bärnthaler |first5=Thomas |last6=Marsh |first6=Leigh M. |last7=Atallah |first7=Reham |last8=Sinn |first8=Katharina |last9=Klepetko |first9=Walter |last10=Sharma |first10=Neha |last11=Nagaraj |first11=Chandran |last12=Heinemann |first12=Akos |date=2020-12-01 |title=Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4 |url=https://www.sciencedirect.com/science/article/pii/S000629522030513X |journal=Biochemical Pharmacology |volume=182 |pages=114277 |doi=10.1016/j.bcp.2020.114277 |pmid=33038299 |issn=0006-2952|doi-access=free }} and interleukins,{{Cite journal |last1=Yu |first1=Hongchi |last2=Huang |first2=Xianliang |last3=Ma |first3=Yunlong |last4=Gao |first4=Min |last5=Wang |first5=Ou |last6=Gao |first6=Ting |last7=Shen |first7=Yang |last8=Liu |first8=Xiaoheng |date=2013 |title=Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions |journal=International Journal of Biological Sciences |volume=9 |issue=9 |pages=966–979 |doi=10.7150/ijbs.6996 |issn=1449-2288 |pmc=3805902 |pmid=24155670}} which leads to most of the symptoms of inflammation (swelling, redness, warmth and pain).

{{Main|Vasoconstriction}}

File:Microvessel.jpg of a microvessel displaying an erythrocyte (E) within its lumen which is deformed due to vasoconstriction]]

Arteries—and veins to a degree—can regulate their inner diameter by contraction of the muscular layer. This changes the blood flow to downstream organs and is determined by the autonomic nervous system. Vasodilation and vasoconstriction are also used antagonistically as methods of thermoregulation.{{cite journal | vauthors = Charkoudian N | title = Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans | journal = Journal of Applied Physiology | volume = 109 | issue = 4 | pages = 1221–1228 | date = October 2010 | pmid = 20448028 | pmc = 2963327 | doi = 10.1152/japplphysiol.00298.2010 }}

The size of blood vessels is different for each of them. It ranges from a diameter of about 30–25 millimeters for the aorta{{Cite journal |last1=Erbel |first1=Raimund |last2=Eggebrecht |first2=Holger |date=2006 |title=Aortic dimensions and the risk of dissection |journal=Heart |language=en |volume=92 |issue=1 |pages=137–142 |doi=10.1136/hrt.2004.055111 |pmc=1861012 |pmid=16365370 |quote=The normal diameter of the abdominal aorta is regarded to be less than 3.0 cm.}} to only about 5 micrometers (0,005{{Nbsp}}mm) for the capillaries.{{Cite journal |last1=Potter |first1=R. F. |last2=Groom |first2=A. C. |date=1983 |title=Capillary diameter and geometry in cardiac and skeletal muscle studied by means of corrosion casts |url=https://pubmed.ncbi.nlm.nih.gov/6835100 |journal=Microvascular Research |volume=25 |issue=1 |pages=68–84 |doi=10.1016/0026-2862(83)90044-4 |issn=0026-2862 |pmid=6835100}} Vasoconstriction is the constriction of blood vessels (narrowing, becoming smaller in cross-sectional area) by contracting the vascular smooth muscle in the vessel walls. It is regulated by vasoconstrictors (agents that cause vasoconstriction). These can include paracrine factors (e.g., prostaglandins), a number of hormones (e.g., vasopressin and angiotensin{{Cite journal |last1=Kanaide |first1=Hideo |last2=Ichiki |first2=Toshihiro |last3=Nishimura |first3=Junji |last4=Hirano |first4=Katsuya |date=2003-11-28 |title=Cellular Mechanism of Vasoconstriction Induced by Angiotensin II |url=https://dx.doi.org/10.1161/01.res.0000105920.33926.60 |journal=Circulation Research |volume=93 |issue=11 |pages=1015–1017 |doi=10.1161/01.res.0000105920.33926.60 |pmid=14645130 |issn=0009-7330}}) and neurotransmitters (e.g., epinephrine) from the nervous system.

Vasodilation is a similar process mediated by antagonistically acting mediators. The most prominent vasodilator is nitric oxide (termed endothelium-derived relaxing factor for this reason).{{Cite journal |last=Cooke |first=John P |date=2000 |title=The endothelium: a new target for therapy |url=https://journals.sagepub.com/doi/10.1177/1358836X0000500108 |journal=Vascular Medicine |language=en |volume=5 |issue=1 |pages=49–53 |doi=10.1177/1358836X0000500108 |pmid=10737156 |issn=1358-863X}}

{{Main |Vascular resistance}}

The circulatory system uses the channel of blood vessels to deliver blood to all parts of the body. This is a result of the left and right sides of the heart working together to allow blood to flow continuously to the lungs and other parts of the body. Oxygen-poor blood enters the right side of the heart through two large veins. Oxygen-rich blood from the lungs enters through the pulmonary veins on the left side of the heart into the aorta and then reaches the rest of the body. The capillaries are responsible for allowing the blood to receive oxygen through tiny air sacs in the lungs. This is also the site where carbon dioxide exits the blood. This all occurs in the lungs where blood is oxygenated.{{cite web | vauthors = Nazario B | date = 17 September 2021 |url=https://www.webmd.com/hypertension-high-blood-pressure/hypertension-working-heart|title=How Your Heart Works |website=WebMD}}

The blood pressure in blood vessels is traditionally expressed in millimetres of mercury (1 mmHg = 133 Pa). In the arterial system, this is usually around 120 mmHg systolic (high pressure wave due to contraction of the heart) and 80 mmHg diastolic (low pressure wave). In contrast, pressures in the venous system are constant and rarely exceed 10 mmHg.{{Citation |last1=Yeo |first1=JuDong |title=Bioactive peptides in health and disease: an overview |date=2021 |work=Biologically Active Peptides |pages=1–26 |url=https://dx.doi.org/10.1016/b978-0-12-821389-6.00007-8 |access-date=2024-10-30 |publisher=Elsevier |isbn=978-0-12-821389-6 |last2=Shahidi |first2=Fereidoon|doi=10.1016/b978-0-12-821389-6.00007-8 }}

Vascular resistance occurs when the vessels away from the heart oppose the flow of blood. Resistance is an accumulation of three different factors: blood viscosity, blood vessel length and vessel radius.{{cite book | vauthors = Saladin KS |title=Anatomy & physiology : the unity of form and function |date=2012 |publisher=McGraw-Hill |location=New York, NY |isbn=978-0-07-131638-5 |edition=6th}} Blood viscosity is the thickness of the blood and its resistance to flow as a result of the different components of the blood. Blood is 92% water by weight and the rest of blood is composed of protein, nutrients, electrolytes, wastes, and dissolved gases. Depending on the health of an individual, the blood viscosity can vary (i.e., anemia causing relatively lower concentrations of protein, high blood pressure an increase in dissolved salts or lipids, etc.).

Vessel length is the total length of the vessel measured as the distance away from the heart. As the total length of the vessel increases, the total resistance as a result of friction will increase. Vessel radius also affects the total resistance as a result of contact with the vessel wall. As the radius of the wall gets smaller, the proportion of the blood making contact with the wall will increase. The greater amount of contact with the wall will increase the total resistance against the blood flow.{{cite news|title=Factors that Affect Blood Pressure|url=https://www.interactivephysiology.com/demo/misc/assignmentfiles/cardiovascular/Fact_Aff_Blood_Pressure.pdf|url-status=dead|access-date=21 October 2018|archive-url=https://web.archive.org/web/20170517024049/https://www.interactivephysiology.com/demo/misc/assignmentfiles/cardiovascular/Fact_Aff_Blood_Pressure.pdf|archive-date=17 May 2017}}

{{Main|Vascular disease}}

Blood vessels play a huge role in virtually every medical condition. Cancer, for example, cannot progress unless the tumor causes angiogenesis (formation of new blood vessels) to supply the malignant cells' metabolic demand.{{cite journal | vauthors = Nishida N, Yano H, Nishida T, Kamura T, Kojiro M | title = Angiogenesis in cancer | journal = Vascular Health and Risk Management | volume = 2 | issue = 3 | pages = 213–219 | date = September 2006 | pmid = 17326328 | pmc = 1993983 | doi = 10.2147/vhrm.2006.2.3.213 | doi-access = free }} Atherosclerosis represents around 85% of all deaths from cardiovascular diseases due to the buildup of plaque.{{Cite journal |date=2023 |title=World Heart Report 2023 |url=https://world-heart-federation.org/wp-content/uploads/World-Heart-Report-2023.pdf |journal=World Heart Federation |publication-place=Geneva, Switzerland |page=5}} Coronary artery disease that often follows after atherosclerosis can cause heart attacks or cardiac arrest, resulting in 370,000 worldwide deaths in 2022.{{Cite web |last=CDC |date=2024-10-24 |title=Heart Disease Facts |url=https://www.cdc.gov/heart-disease/data-research/facts-stats/index.html |access-date=2024-10-30 |website=Heart Disease |language=en-us}} In 2019, around 17.9 million people died from cardiovascular diseases. Of these deaths, around 85% of them were due to heart attack and stroke.{{Cite web |title=Cardiovascular diseases (CVDs) |url=https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) |access-date=2024-10-30 |website=World Health Organization |language=en}}

Blood vessel permeability is increased in inflammation. Damage, due to trauma or spontaneously, may lead to hemorrhage due to mechanical damage to the vessel endothelium. In contrast, occlusion of the blood vessel by atherosclerotic plaque, an embolised blood clot or a foreign body leads to downstream ischemia (insufficient blood supply) and possibly infarction (necrosis due to lack of blood supply). Vessel occlusion tends to be a positive feedback system; an occluded vessel creates eddies in the normally laminar flow or plug flow blood currents. These eddies create abnormal fluid velocity gradients which push blood elements, such as cholesterol or chylomicron bodies, to the endothelium. These deposit onto the arterial walls which are already partially occluded and build upon the blockage.{{cite book | vauthors = Gidaspow D |title=Multiphase flow and fluidization : continuum and kinetic theory descriptions |date=1994 |publisher=Academic Press |location=Boston |isbn=978-0-12-282470-8}}

The most common disease of the blood vessels is hypertension or high blood pressure. This is caused by an increase in the pressure of the blood flowing through the vessels. Hypertension can lead to heart failure and stroke. Aspirin helps prevent blood clots and can also help limit inflammation.{{cite web|url=https://www.mercyhealth.org/services/heart/heart-disease/blood-vessels/ | archive-url = https://web.archive.org/web/20161018074232/https://www.mercyhealth.org/services/heart/heart-disease/blood-vessels/ | archive-date = 18 October 2016 |title=Blood Vessel Diseases – Mercy Health System|website=www.mercyhealth.org}} Vasculitis is inflammation of the vessel wall due to autoimmune disease or infection.

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{{Arteries and veins}}

{{Arteries}}

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Category:Angiology

Category:Cardiovascular system anatomy

Category:Soft tissue