BolA-like protein family

{{Infobox protein family

| Symbol = BolA

| Name = BolA

| image = PDB 1ny8 EBI.jpg

| width =

| caption = solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115

| Pfam = PF01722

| Pfam_clan =

| InterPro = IPR002634

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1v9j

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator;{{cite journal |vauthors=Dressaire C, Moreira RN, Barahona S, Alves de Matos AP, Arraiano CM, Santos JM, Freire P, Vicente M, Arraiano CM | title = BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development | journal = mBio | volume = 6 | issue = 1 | pages = e02352-14 | pmid = 25691594 | doi = 10.1128/mBio.02352-14

| date = 17 February 2015 | pmc=4337573}} the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels

.{{cite journal |vauthors=Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE |title=The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation |journal=Biochemistry |volume=48 |issue=40 |pages=9569–81 |year=2009 |pmid=19715344 |pmc=2796373 |doi=10.1021/bi901182w }}

In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.{{cite journal |vauthors=Santos JM, Freire P, Vicente M, Arraiano CM | title = The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth | journal = Mol. Microbiol. | volume = 32 | issue = 4 | pages = 789–98 |date=May 1999 | pmid = 10361282 | doi = 10.1046/j.1365-2958.1999.01397.x| s2cid = 25213524 | doi-access = free }} The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.{{cite journal |vauthors=Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR | title = Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene | journal = EMBO J. | volume = 8 | issue = 12 | pages = 3923–31 |date=December 1989 | pmid = 2684651 | pmc = 402084 | doi = 10.1002/j.1460-2075.1989.tb08573.x}}