Brain-specific angiogenesis inhibitor 3
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 103–108 | date = Apr 1998 | pmid = 9533023 | doi = 10.1159/000134693 }}{{cite web | title = Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=577}}
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.{{cite journal | vauthors = Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F | title = The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons | journal = Molecular Psychiatry | volume = 18 | issue = 8 | pages = 943–950 | date = August 2013 | pmid = 23628982 | pmc = 3730300 | doi = 10.1038/mp.2013.46 }}
The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.{{cite journal | vauthors = Bolliger MF, Martinelli DC, Südhof TC | title = The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 6 | pages = 2534–2539 | date = February 2011 | pmid = 21262840 | doi = 10.1073/pnas.1019577108 | pmc = 3038708 | bibcode = 2011PNAS..108.2534B | doi-access = free }} BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
References
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Further reading
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- {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = June 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
- {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 1 | pages = 31–39 | date = February 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 | doi-access = free }}
- {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = July 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }}
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External links
- {{UCSC gene info|ADGRB3}}
{{NLM content}}
{{G protein-coupled receptors}}
Category:G protein-coupled receptors
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