Bramah N. Singh
{{Short description|Cardiac pharmacologist and academic (1938–2014)}}
Bramah N. Singh (3 March 1938 – 20 September 2014) was a cardiac pharmacologist and academic.{{cite web|last1=Champeau|first1=Rachel|title=In memoriam: Cardiologist Dr. Bramah Singh, expert on arrhythmias|url=http://newsroom.ucla.edu/dept/faculty/in-memoriam:-cardiologist-dr-bramah-singh-expert-on-arrhythmias|website=UCLA Newsroom|access-date=21 July 2017|language=en}}{{cite journal|last1=Naccarelli|first1=GV|title=Bramah N. Singh, MD, DPhil, DSc: A Tribute.|journal=Journal of Cardiovascular Pharmacology and Therapeutics|date=May 2015|volume=20|issue=3|pages=342–3|doi=10.1177/1074248415574744|pmid=25736281|s2cid=37440331 }}{{cite news|last1=Raven|first1=Julia|title=Bramah Singh, renowned UCLA cardiologist, dies at 76|url=http://dailybruin.com/2014/10/17/bramah-singh-renowned-ucla-cardiologist-dies-at-76/|access-date=21 July 2017|agency=Daily Bruin|date=17 October 2014}}
Early life and education
Born in Fiji, he graduated in medicine from University of Otago (New Zealand) in 1963 and completed residency at Auckland Hospital, followed by a cardiology fellowship at Green Lane Hospital. In 1969, Singh was awarded a Nuffield travelling fellowship and moved to Oxford to work with Miles Vaughan Williams. There, he worked on the anti-arrhythmic properties of drugs including amiodarone.{{cite journal|last1=Singh|first1=BN|last2=Vaughan Williams|first2=EM|title=A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474.|journal=British Journal of Pharmacology|date=August 1970|volume=39|issue=4|pages=675–87|pmid=5485144|pmc=1702723|doi=10.1111/j.1476-5381.1970.tb09893.x}}{{cite journal|last1=Singh|first1=BN|last2=Vaughan Williams|first2=EM|title=The effect of amiodarone, a new anti-anginal drug, on cardiac muscle.|journal=British Journal of Pharmacology|date=August 1970|volume=39|issue=4|pages=657–67|pmid=5485142|pmc=1702721|doi=10.1111/j.1476-5381.1970.tb09891.x}} Such work helped to refine the characteristics of Class III compounds in the developing Vaughan Williams classification.{{cite journal | vauthors = Kloner RA | year = 2009 | title = A Salute to Our Founding Editor-in-Chief Bramah N. Singh, MD, DPhil, DSc, FRCP | journal = Journal of Cardiovascular Pharmacology and Therapeutics | volume = 14 | issue = 3| pages = 154–156 | doi=10.1177/1074248409343182| pmid = 19721129 | s2cid = 44733401 | doi-access = free }}
Career
Some reviews on antidysrhythmic drugs during his lifetime credited his work in developing the classification system equally with Vaughan Williams, leading to the classification sometimes being called the Singh Vaughan Williams classification.{{cite journal|last1=Nattel|first1=S|title=Comparative mechanisms of action of antiarrhythmic drugs.|journal=The American Journal of Cardiology|date=26 November 1993|volume=72|issue=16|pages=13F–17F|pmid=8237825|doi=10.1016/0002-9149(93)90959-G}}{{cite journal|last1=Nattel|first1=S|title=Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance.|journal=Drugs|date=May 1991|volume=41|issue=5|pages=672–701|pmid=1712704|doi=10.2165/00003495-199141050-00002|s2cid=46975925}}{{cite journal|last1=Kowey|first1=PR|last2=Marinchak|first2=RA|last3=Rials|first3=SJ|last4=Bharucha|first4=D|title=Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs.|journal=The American Journal of Cardiology|date=23 October 1997|volume=80|issue=8A|pages=16G–23G|pmid=9354408|doi=10.1016/S0002-9149(97)00710-8}}
References
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Category:University of Otago alumni
Category:American cardiologists
Category:Alumni of Hertford College, Oxford