Brian Kuhlman

Kuhlman obtained Bachelor of Arts degree in chemical physics from Rice University in 1992. From 1993 to 1998 he studied under guidance of Daniel Raleigh to earn his Ph.D. in chemistry from Stony Brook University and from 1999 to 2002 he studied under guidance from David Baker to obtain Damon Runyon Postdoctoral Fellowship at the University of Washington.

In 2003, Kuhlman designed the first full-domain artificial protein, Top7, with Gautam Dantas and other researchers, in David Baker's laboratory. In his independent research laboratory, Kuhlman continued pioneering research in protein design, including breakthroughs in design of protein conformational switches,{{cite journal |author1=Ambroggio, X. |display-authors=et al|title=Computational design of a single amino acid sequence that can switch between two distinct protein folds |journal=J Am Chem Soc |year=2006 |volume=128 |issue=4 |pages=1154-61 |doi=10.1021/ja054718w |pmid=16433531 |url=https://pubs.acs.org/doi/10.1021/ja054718w|url-access=subscription }} protein interface design, design of protein loops,{{cite journal|author=Hu, X.|display-authors=et al|title=High-resolution design of a protein loop|journal=Proc Natl Acad Sci U S A|year=2007|volume=104|issue=45|pages=17668–73|doi=10.1073/pnas.0707977104|pmid=17971437|pmc=2077077|bibcode=2007PNAS..10417668H|doi-access=free}} stitching together components of natural proteins,{{cite news|title=Frankenstein Proteins Stitched Together by Scientists|url=https://www.genengnews.com/topics/bioprocessing/frankenstein-proteins-stitched-together-by-scientists/|date=May 11, 2016|accessdate=August 13, 2019}} designed fusions for bispecific antibodies,{{cite journal|author1=Lewis, Steven M.|display-authors=et al|title=Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface|journal=Nature Biotechnology|year=2014|volume=32|issue=2|pages=191–8|doi=10.1038/nbt.2797|pmid=24463572|s2cid=10961481}} and progress toward vaccines.{{cite web|url=https://www.sciencedaily.com/releases/2018/05/180518141035.htm|title=Researchers discover how body temperature wrecks potential dengue, Zika vaccine|website=ScienceDaily|date=May 18, 2018|accessdate=August 13, 2019}}

• DeLano Award for Computational Biosciences{{cite news|url=https://www.med.unc.edu/biochem/news/kuhlman-wins-delano-award-for-computer-applications-to-enhance-research/|title=Kuhlman wins DeLano Award for computer applications to enhance research|publisher=UNC Health Care|date=July 5, 2018|accessdate=August 13, 2019}}
• Feynman Prize in Nanotechnology{{cite news|url=https://www.med.unc.edu/biochem/news/brian-kuhlman-ph-d-protein-robotics-making-science-fun-while-improving-human-health/|title=Brian Kuhlman, Ph.D., Protein Robotics: Making Science Fun while Improving Human Health|publisher=UNC Health Care|date=September 1, 2018|accessdate=August 13, 2019}}
• Beckman Young Investigator

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Category:Living people

Category:American biochemists

Category:American biophysicists

Category:Rice University alumni

Category:Stony Brook University alumni

Category:University of Washington alumni

Category:Sloan Research Fellows

Category:University of North Carolina at Chapel Hill faculty

Category:Year of birth missing (living people)

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