Bromoderma
{{Infobox medical condition (new)
| name = Bromoderma
| synonyms = Bromoderma tuberosum
| image =
| caption =
| pronounce =
| field = Dermatology
| symptoms =
| complications =
| onset =
| duration =
| types =
| causes =
| risks =
| diagnosis =
| differential =
| prevention =
| treatment =
| medication =
| prognosis =
| frequency =
| deaths =
}}
Bromoderma is a skin condition characterized by an eruption of papules and pustules on the skin.{{cite book | vauthors = James WD, Berger T, Elston D |title=Andrews' Diseases of the Skin: Clinical Dermatology |date=2006 |publisher=Saunders Elsevier |location=Philadelphia |isbn=978-0-7216-2921-6 |edition=10th}}{{rp|135}} It is caused by hypersensitivity to bromides, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a soft drink (Ruby Red Squirt) containing brominated vegetable oil.{{cite journal | vauthors = Jih DM, Khanna V, Somach SC | title = Bromoderma after excessive ingestion of Ruby Red Squirt | journal = The New England Journal of Medicine | volume = 348 | issue = 19 | pages = 1932–1934 | date = May 2003 | pmid = 12736294 | doi = 10.1056/NEJM200305083481921 | doi-access = free }}
Signs and symptoms
The disease's symptoms can range from a mild acneiform rash with papules and pustules to more severe conditions like panniculitis, ulcers, and vegetative nodules, also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.{{cite journal | last1=Nabatame | first1=Shin | last2=Saito | first2=Yoshiaki | last3=Sakuma | first3=Hiroshi | last4=Komaki | first4=Hirofumi | last5=Nakagawa | first5=Eiji | last6=Sugai | first6=Kenji | last7=Sasaki | first7=Masayuki | last8=Uchiyama | first8=Kentaro | last9=Kosaka | first9=Maki | title=Bromoderma in a patient with migrating partial seizures in infancy | journal=Epilepsy Research | publisher=Elsevier BV | volume=91 | issue=2–3 | year=2010 | issn=0920-1211 | doi=10.1016/j.eplepsyres.2010.07.008 | pages=283–288| pmid=20674275 | s2cid=3408441 }}{{cite journal | last1=Anzai | first1=Saburo | last2=Fujiwara | first2=Sakuhei | last3=Inuzuka | first3=Miki | title=Bromoderma | journal=International Journal of Dermatology | publisher=Wiley | volume=42 | issue=5 | year=2003 | issn=0011-9059 | doi=10.1046/j.1365-4362.2003.01734.x | pages=370–371| pmid=12755974 | s2cid=221812784 }}
Causes
One could characterize bromoderma as a kind of delayed hypersensitivity reaction, even though its pathogenesis is still unknown.{{cite journal | last1=Maffeis | first1=Laura | last2=Musolino | first2=Maria Carmela | last3=Cambiaghi | first3=Stefano | title=Single-plaque vegetating bromoderma | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=58 | issue=4 | year=2008 | issn=0190-9622 | doi=10.1016/j.jaad.2007.08.011 | pages=682–684| pmid=18342716 }} Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.{{cite journal | last1=Hoefel | first1=Isadora da Rosa | last2=Camozzato | first2=Fernanda Oliveira | last3=Hagemann | first3=Laura Netto | last4=Rhoden | first4=Deise Louise Bohn | last5=Kiszewski | first5=Ana Elisa | title=Bromoderma in an infant | journal=Anais Brasileiros de Dermatologia | publisher=FapUNIFESP (SciELO) | volume=91 | issue=5 suppl 1 | year=2016 | issn=0365-0596 | doi=10.1590/abd1806-4841.20165013 | pages=17–19| pmid=28300882 | pmc=5324981 }}
Diagnosis
Skin lesions, a patient's history of using bromide, and the healing of lesions following drug withdrawal can all be used to make a diagnosis.{{cite journal | last1=Bel | first1=Susana | last2=Bartralot | first2=Ramón | last3=García | first3=Daniel | last4=Aparicio | first4=Gloria | last5=Castells | first5=Antonio | title=Vegetant Bromoderma in an Infant | journal=Pediatric Dermatology | publisher=Wiley | volume=18 | issue=4 | year=2001 | issn=0736-8046 | doi=10.1046/j.1525-1470.2001.01954.x | pages=336–338| pmid=11576411 | s2cid=19631925 }}
See also
References
{{reflist}}
Further reading
- {{cite journal | last1=Paloni | first1=Giulia | last2=Mattei | first2=Ilaria | last3=Ravagnan | first3=Enrico | last4=Cutrone | first4=Mario | title=Infantile Bromoderma | journal=The Journal of Pediatrics | publisher=Elsevier BV | volume=163 | issue=3 | year=2013 | issn=0022-3476 | doi=10.1016/j.jpeds.2013.03.071 | pages=920–920.e1 | pmid=23651770 | ref=none}}
External links
{{Medical resources
| ICD11 = {{ICD11|ED81.Y}}
| ICD10 = {{ICD10|L27.1}}
| ICD10CM =
| ICD9 = {{ICD9|693.0}}
| ICDO =
| OMIM =
| MeshID =
| DiseasesDB =
| SNOMED CT = 8007005
| Curlie =
| MedlinePlus =
| eMedicineSubj =
| eMedicineTopic =
| PatientUK =
| NCI =
| GeneReviewsNBK =
| GeneReviewsName =
| NORD =
| GARDNum =
| GARDName =
| RP =
| AO =
| WO =
| OrthoInfo =
| Orphanet =
| Scholia = Q4973728
| OB =
}}
{{Noninfectious inflammatory cutaneous conditions}}
{{Disorders of skin appendages}}