Brunner's glands

Duodenal glands are situated within the mucosa and submucosa of the duodenum. They are most abundant near the pylorus, growing shorter and more sparse distally towards the terminal portion of the duodenum.{{Cite web |title=Dictionnaire médical de l'Académie de Médecine |url=https://www.academie-medecine.fr/le-dictionnaire/index.php?q=glandes+duod%C3%A9nales |access-date=2023-11-10 |website=www.academie-medecine.fr}}

The duodenum can be distinguished from the jejunum and ileum by the presence of Brunner's glands in the submucosa.{{citation needed|date=November 2023}}

Their excretory cannals are tortuous, opening at the bases of the villi.

Two forms of duodenal glands are distinguished: the external group (which are more voluminous and extend into the duodenal submucosa), and the internal group (which are smaller and are situated within the duodenal mucosa).

They also secrete epidermal growth factor, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes.{{Cite journal |last1=Gregory |first1=H. |last2=Preston |first2=B. M. |date=1977-01-01 |title=The primary structure of human urogastrone |journal=International Journal of Peptide and Protein Research |volume=9 |issue=2 |pages=107–118 |doi=10.1111/j.1399-3011.1977.tb03470.x |issn=0367-8377 |pmid=300079}}{{citation needed|date=May 2015}} This is another form of protection for the duodenum.{{citation needed|date=November 2023}}

The Brunner glands, which empty into the intestinal glands, secrete an alkaline fluid composed of mucin, which exerts a physiologic anti-acid function by coating the duodenal epithelium, therefore protecting it from the acid chyme of the stomach. Furthermore, in response to the presence of acid in the duodenum, these glands secrete pepsinogen and urogastrone, which inhibit gastric acid secretion.{{citation needed|date=May 2014}}

More recent studies have demonstrated that Brunner’s glands are major modulators of the gut microbiome and systemic immunity. Studies conducted by Ivan De Araujo’s laboratory revealed that Brunner’s gland secretions promote the proliferation of probiotics and protect the host against foreign pathogens.{{cite journal| author=Chang H, Perkins MH, Novaes LS, Qian F, Zhang T, Neckel PH, Scherer S, Ley RE, Han W, de Araujo I | display-authors=etal| title=Stress-sensitive neural circuits change the gut microbiome via duodenal glands. | journal=Cell | year= 2024 | volume= 187 | issue= 19 | pages= 5393–5412.e30 | pmid=39121857 | doi=10.1016/j.cell.2024.07.019 | pmc=11425084 | pmc-embargo-date=September 19, 2025}}

Hyperplasia of Brunner glands with a lesion greater than 1 cm was initially described as a Brunner gland adenoma.{{Cite journal |last=Abbass |first=Rami |last2=Al-Kawas |first2=Firas H. |date=July 2008 |title=Brunner gland hamartoma |journal=Gastroenterology & Hepatology |volume=4 |issue=7 |pages=473–475 |issn=1554-7914 |pmc=3096129 |pmid=21960922}} Several features of these lesions favor their designation as hamartomas, including the lack of encapsulation; the mixture of acini, smooth muscles, adipose tissue, Paneth cells, and mucosal glands; and the lack of any cell atypia. These hamartomas are rare, with approximately 150 cases described in the literature. It is estimated that they represent approximately 5–10% of benign duodenal tumors. They are variable in size, typically 1–3 cm, with only a few reported cases of lesions larger than 5 cm.{{Cite journal |last=Zhu |first=Menghua |last2=Li |first2=Hongyu |last3=Wu |first3=Yanyan |last4=An |first4=Yang |last5=Wang |first5=Yuye |last6=Ye |first6=Chun |last7=Zhang |first7=Dan |last8=Ma |first8=Rui |last9=Wang |first9=Xuehan |last10=Shao |first10=Xiaodong |last11=Guo |first11=Xiaozhong |last12=Qi |first12=Xingshun |date=June 2021 |title=Brunner's Gland Hamartoma of the Duodenum: A Literature Review |journal=Advances in Therapy |volume=38 |issue=6 |pages=2779–2794 |doi=10.1007/s12325-021-01750-6 |issn=1865-8652 |pmc=8189944 |pmid=33914269}}

Most patients with Brunner gland hamartomas are asymptomatic or have nonspecific complaints such as nausea, bloating, or vague abdominal pain.{{Cite journal |last=Barbeiro |first=Sandra |last2=Martins |first2=Catarina Atalaia |last3=Marcos |first3=Pedro |last4=Gonçalves |first4=Cláudia |date=2015-11-01 |title=Brunner's Gland Hamartoma – A Rare Cause of Upper Gastrointestinal Bleeding |journal=GE - Portuguese Journal of Gastroenterology |language=en |volume=22 |issue=6 |pages=283–285 |doi=10.1016/j.jpge.2015.06.005 |issn=2341-4545|pmc=5580153 }}

Most reports in the literature describe local surgical resection of Brunner gland hamartoma via duodenotomy. Increasingly, successful endoscopic resection has been reported and is primarily used for pedunculated Brunner gland hamartomas. The endoscopic approach in selective cases appears to be safe, less invasive, and less costly.{{Cite journal |last=Keihanian |first=Tara |last2=England |first2=Jonathan S. |last3=Amin |first3=Sunil |date=October 2020 |title=Endoscopic resection of a duodenal Brunner gland hamartoma presenting with GI bleeding |journal=VideoGIE: An Official Video Journal of the American Society for Gastrointestinal Endoscopy |volume=5 |issue=10 |pages=486–487 |doi=10.1016/j.vgie.2020.05.019 |issn=2468-4481 |pmc=7570429 |pmid=33103005}}

Consistent with the more recent idea that Brunner’s glands influence systemic immunity via the microbiome, patients who had the duodenal bulb removed (where the glands are mostly located) showed greater alterations in immune factors compared to patients having  more distal parts of the duodenum removed.

• Peutz–Jeghers syndrome
• List of distinct cell types in the adult human body

{{Reflist}}

• {{BUHistology|11504loa}} - "Digestive System: Alimentary Canal: pyloro/duodenal junction, duodenum"
• {{BUHistology|11513loa}} - "Digestive System: Alimentary Canal: pyloro/duodenal junction"
• {{BUHistology|11609loa}} - "Digestive System: Alimentary Canal: duodenum, plicae circularis"

{{Gastrointestinal tract}}

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Category:Digestive system