Bryan Roth
{{Infobox academic|honorific_prefix=|era=|website=|education=|alma_mater=Carroll College, BA (1977)
St. Louis University Medical School, MD, PhD (1983)
|thesis_title=|thesis_url=|thesis_year=|school_tradition=|doctoral_advisor=|academic_advisors=|influences=|discipline=Molecular Pharmacology|relatives=|sub_discipline=|workplaces= University of North Carolina
Case Western Reserve University|doctoral_students=|notable_students=|main_interests=|notable_works=|notable_ideas=|influenced=|signature=|signature_alt=|signature_size=|awards=Michael Hooker Distinguished Professor of Pharmacology (2006-)
Goodman and Gilman Award for Receptor Pharmacology (2016)
Member, National Academy of Medicine.
Member, American Academy of Arts and Sciences.
|parents=|name=Bryan Roth|death_place=|honorific_suffix=|image=|image_size=|alt=|caption=|native_name=|native_name_lang=|birth_name=|birth_date=|birth_place=|death_date=|death_cause=|children=|nationality=|citizenship=USA|other_names=|occupation=Professor|period=|known_for=|home_town=|title=|boards=Executive Editor, Biochemistry|spouse=|partner=|footnotes=}}Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine.{{Cite web|title=Bryan Roth, MD, PhD|url=https://www.med.unc.edu/pharm/directory/bryan-roth-md-phd/|access-date=2021-10-16|website=Pharmacology|language=en-US}} He is recognized for his discoveries and inventions in the general areas of molecular pharmacology, GPCR structure, and function and synthetic neurobiology. He is a member of the American Academy of Arts and Sciences (AAAS) and the National Academy of Medicine (NAM).
Education
Roth earned his B.A. in biology from Carroll College in 1977 and his M.D. and Ph.D. in biochemistry from Saint Louis University in 1983. After postdoctoral training at the National Institute of Mental Health (NIMH), he completed a psychiatry residency and fellowship at Stanford University in 1991. The same year, he was appointed Assistant Professor in the Department of Psychiatry at Case Western Reserve University. In 2003 he became a Professor of Biochemistry at Case Western Reserve University School of Medicine with secondary appointments in Psychiatry, Oncology, and Neurosciences. {{Cite web |last=Roth |first=Bryan |title=Biographical Sketch |url=https://www.med.unc.edu/pharm/wp-content/uploads/sites/930/2020/08/Roth_biosketch-2020-w.pdf|url-status=live |access-date=16 October 2021 |website=UNC School of Medicine |archive-url=https://web.archive.org/web/20211016001510/https://www.med.unc.edu/pharm/wp-content/uploads/sites/930/2020/08/Roth_biosketch-2020-w.pdf |archive-date=2021-10-16 }} In 2007 he was appointed as the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine.{{Cite web |last=Roth |first=Bryan |title=Biographical Sketch |url=https://www.med.unc.edu/pharm/wp-content/uploads/sites/930/2020/08/Roth_biosketch-2020-w.pdf|url-status=live |access-date=16 October 2021 |website=UNC School of Medicine |archive-url=https://web.archive.org/web/20211016001510/https://www.med.unc.edu/pharm/wp-content/uploads/sites/930/2020/08/Roth_biosketch-2020-w.pdf |archive-date=2021-10-16 }}
Research
Roth has made contributions to the fields of G protein-coupled receptor (GPCR) pharmacology and neurobiology, particularly related to the function of serotonin and opioid receptors. His laboratory reported the structure of a serotonin receptor bound to the hallucinogenic drug, LSD.Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan, AJ, Levit A, Lansu K, Schools Z, Che T, Nichols DE, Shoichet BK, Dror RD, and Roth BL: [https://reader.elsevier.com/reader/sd/pii/S0092867416317494?token=26F07B04E429ED2FE39623CB97CE6720B082DE8D3853457E9E00E4D870CB217847F01A8C5FBB211F9E5376B6E3E356DA&originRegion=us-east-1&originCreation=20230327173147 Crystal structure of an LSD-bound human serotonin receptor]. Cell 168: 377-389Kim...and Roth, Cell 182: 1574-1588, 2020 Other major works include identification of new probes and tools to detect GPCRs, obtained through directed evolution in animal cells,English JG. Olsen, RHJ, Lansu K, Patel M, White K, Cockrell AS, Sing D, Strachan RT, Wacker D and Roth BL. [https://www.sciencedirect.com/science/article/pii/S0092867419306221 VEGAS as a platform for facile directed evolution in mammalian cells]. Cell 178: 748-761, 2019 developing receptors activated solely by a synthetic ligand (DREADDs), a chemogenetic platform used to direct selective, dose-dependent activation of a specific G protein subtype in vivo.BN Armbruster, X Li, S Herlitzer, M Pausch and BL Roth: Evolving the lock to fit the key to create a family of GPCRs potently activated by an inert ligand. Proc Natl Acad Sci 2007 Mar 20;104(12):5163-8 (Highlighted on Cover) PMID 17350345 Thomas Insel, then Director of NIMH, stated in 2014 that DREADDs were one of the most important breakthrough technologies for the NIH BRAIN Initiative.{{cite web |url=https://www.nimh.nih.gov/about/directors/thomas-insel/blog/2014/best-of-2014.shtml#6 |title=Post by Former NIMH Director Thomas Insel: Best of 2014 |website=National Institute of Mental Health |url-status=dead |archive-url=https://web.archive.org/web/20161215165649/https://www.nimh.nih.gov/about/directors/thomas-insel/blog/2014/best-of-2014.shtml |archive-date=2016-12-15}} and have been used by more than a thousand labs for interrogating neural circuits responsible for simple and complex behaviors in animals.
Awards and recognition
Roth’s work has been recognized by Science Signaling as one of the ‘Signaling Breakthroughs of ‘2014’{{Cite journal |last=Berndt |first=Jason D. |last2=Wong |first2=Wei |date=2015-01-06 |title=2014: Signaling Breakthroughs of the Year |url=https://www.science.org/doi/10.1126/scisignal.aaa4696 |journal=Science Signaling |language=en |volume=8 |issue=358 |doi=10.1126/scisignal.aaa4696 |issn=1945-0877}} and 2016.{{Cite journal |last=Adler |first=Elizabeth M. |date=2017-01-03 |title=2016: Signaling Breakthroughs of the Year |url=https://www.science.org/doi/10.1126/scisignal.aam5681 |journal=Science Signaling |language=en |volume=10 |issue=460 |doi=10.1126/scisignal.aam5681 |issn=1945-0877}} His DREADD technology was highlighted as one of the important advances in the past 10 years in Nature Chemical Biology.{{Cite journal |date= |title=Voices of chemical biology |url=https://www.nature.com/articles/nchembio.1845 |journal=Nature Chemical Biology |language=en |volume=11 |issue=7 |pages=446–447 |doi=10.1038/nchembio.1845 |issn=1552-4469}} Roth’s chemical biology discoveries have been highlighted by NIMH as one of the ‘Top 10 Research Advances of 2011’.{{cite web |last1=Insel |first1=Thomas |author1-link=Thomas R. Insel |title=NIMH's top 10 research advances of 2011 |url=http://www.nimh.nih.gov/about/director/2011/nimhs-top-10-research-advances-of-2011.shtml |website=National Institute of Mental Health |access-date=27 March 2023 |archive-url=https://web.archive.org/web/20120118171424/http://www.nimh.nih.gov/about/director/2011/nimhs-top-10-research-advances-of-2011.shtml |archive-date=2012-01-18 |date=23 December 2011 |url-status=dead}}{{cbignore}}{{cite magazine |title=Top scientific breakthroughs of 2009 |magazine=Wired |date=December 2009 |url=https://www.wired.com/2009/12/discoveries-gallery}}
Roth is a member of the American Academy of Arts and Sciences (AAAS) and the National Academy of Medicine (NAM).
He received the [https://www.aspet.org/aspet/meetings-awards/aspet-awards/aspet-scientific-achievement-awards/the-goodman-and-gilman-award-in-receptor-pharmacology Goodman and Gilman Award in Receptor Pharmacology] from the American Society for Pharmacology and Experimental Therapeutics and was a 2018 [https://www.med.unc.edu/neuroscience/bryan-roth-md-phd-to-give-presidential-special-lecture-at-2018-sfn-meeting/ Society for Neuroscience Presidential Special Lecture].
References
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Category:Year of birth missing (living people)
Category:Saint Louis University alumni
Category:Carroll College (Montana) alumni
Category:University of North Carolina faculty