C-myc internal ribosome entry site (IRES)

{{Infobox rfam

| Name = c-myc internal ribosome entry site (IRES)

| image = RF00216.jpg

| width =

| caption = Predicted secondary structure and sequence conservation of IRES_c-myc

| Symbol = IRES_c-myc

| AltSymbols = c-myc_IRES

| Rfam = RF00216

| miRBase =

| miRBase_family =

| RNA_type = Cis-reg; IRES

| Tax_domain = Eukaryota

| GO = {{GO|0043022}}

| SO = {{SO|0000243}}

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| PDB =

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}}

The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.{{cite journal | vauthors = Le Quesne JP, Stoneley M, Fraser GA, Willis AE | title = Derivation of a structural model for the c-myc IRES | journal = Journal of Molecular Biology | volume = 310 | issue = 1 | pages = 111–126 | date = June 2001 | pmid = 11419940 | doi = 10.1006/jmbi.2001.4745 }}